1.Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea.
Ja Yoon CHOI ; Jeong Mi LEE ; Yun Won JO ; Hyun Ju MIN ; Hyun Jin KIM ; Woon Tae JUNG ; Ok Jae LEE ; Haesun YUN ; Yeong Sil YOON
Clinical and Molecular Hepatology 2013;19(3):309-314
The recent increase in the number of cases of indigenous hepatitis E virus (HEV) infection highlights the importance of identifying the transmission routes for the prevention of such infections. Presented herein is the first case of acute HEV infection after ingesting wild roe deer meat in South Korea. A 43-year-old male presented with abdominal discomfort and jaundice. He had not recently traveled abroad, but had eaten raw roe-deer meat 6-8 weeks before the presentation. On the 7th day of hospitalization the patient was diagnosed with acute viral hepatitis E. Phylogenetic analysis of his serum revealed genotype-4 HEV. This case supports the possibility of zoonotic transmission of HEV because the patient appears to have been infected with genotype-4 HEV after ingesting raw deer meat.
Adult
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Alanine Transaminase/blood
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Animals
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Bilirubin/blood
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Deer/virology
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Genotype
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Hepatitis E/*diagnosis/transmission/virology
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Hepatitis E virus/classification/*genetics/isolation & purification
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Humans
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Male
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Phylogeny
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RNA, Viral/analysis
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Republic of Korea
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Travel
2.Survey of perinatal hepatitis B virus transmission after Korean National Prevention Program in a tertiary hospital.
Jae Hoon KIM ; Ju Seung KIM ; Jong Joon LEE ; Jung Ho KIM ; Suk Young KIM ; Young Kul JUNG ; Oh Sang KWON ; Yun Soo KIM ; Duck Joo CHOI ; Ju Hyun KIM
The Korean Journal of Internal Medicine 2014;29(3):307-314
BACKGROUND/AIMS: The Ministry of Health and Welfare and the Korea Centers for Disease Control and Prevention in South Korea have been organizing hepatitis B virus (HBV) vertical infection prevention projects since July 2002. In this single-institute study, the results of surveys conducted in target mothers who delivered babies in a tertiary hospital were investigated and analyzed. METHODS: Of the 9,281 mothers and their 9,824 neonates born between July 2002 and December 2012, 308 hepatitis B surface antigen (HBsAg)-positive mothers and their 319 neonates were selected for this study, and their records were analyzed retrospectively. RESULTS: A total of 308 mothers were HBsAg-positive, with an HBV prevalence of 3.32% (308/9,281). There were 319 neonates born to these HBsAg-positive mothers, and 252 were confirmed to as either HBsAg-positive or -negative. Four were confirmed as HBsAg-positive, with a 1.59% (4/252) HBV vertical infection rate. All the mothers of neonates who had an HBV vertical infection were hepatitis B e antigen (HBeAg)-positive. Among the HBsAg-positive neonates, three were HBeAg-positive and had an HBV DNA titer of 1.0 x 10(8) copies/mL. CONCLUSIONS: The HBV prevalence of mothers was 3.32% (308/9,281), and their vertical infection rate was 1.59% (4/252). Thus, the South Korean HBV vertical infection prevention projects are effective, and, accordingly, HBV prevalence in South Korea is expected to decrease continuously.
Adult
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Biological Markers/blood
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DNA, Viral/blood
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Female
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Health Surveys
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Hepatitis B/blood/diagnosis/epidemiology/prevention & control/*transmission/virology
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Hepatitis B Surface Antigens/blood
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Hepatitis B e Antigens/blood
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Hepatitis B virus/genetics/immunology
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Humans
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Infant, Newborn
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*Infectious Disease Transmission, Vertical/prevention & control
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*National Health Programs
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Pregnancy
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Prevalence
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Republic of Korea/epidemiology
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Retrospective Studies
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*Tertiary Care Centers
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Viral Load