1.A Study on Viral Hepatitis Markers and Abnormal Liver Function Test in Adults Living in Northwest Area of Chungnam.
Suk Bae KIM ; Won Kyung LEE ; Hoon CHOI ; So Mi KIM ; Rhan NOH ; Ha Yan KANG ; Sang Suk LEE ; Sung Soo RA ; Jae Hwan GONG ; Hyun Duk SHIN
The Korean Journal of Gastroenterology 2009;53(6):355-360
BACKGROUND/AIMS: We studied the prevalence of chronic hepatitis B, C and abnormality on liver function among the population in northwest area of Chungnam. METHODS: We have reviewed 40,112 adults who had received medical examination at health promotion center in Dankook university hospital. We studied them retrospectively about HBsAg, HBsAb, anti-HCV, and liver function test (LFT). RESULTS: Among the study subjects, 22,936 men and 17,176 women were involved. The overall seroprevalence of HBsAg was 4.2%. The prevalence in men (4.5%) was higher than that of women (3.7%) (p<0.001). The seroprevalence of HBsAg in their age was 5.1% in the 5th decade, 4.2% in the 2nd decade, 4.1% in the 4th decade, and 4.1% in the 6th decade. The overall seroprevalence of HBsAb was 65.1%. The overall seroprevalence of anti-HCV was 0.7%. After we reexamined them with HCV RNA or RIBA (Recombinant Immunoblot Assay), the prevalence of chronic hepatitis C was 0.09%. The LFT abnormality in total subjects was 11.4%. The LFT abnormality of chronic hepatitis B and C subjects was 21.72% and 63.2%. CONCLUSIONS: The prevalence of chronic hepatitis B and C was lower than that of previous studies. The prevalence of chronic hepatitis B in the 2nd decade was still high.
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Female
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Hepatitis B Antibodies/blood
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Hepatitis B Surface Antigens/blood
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Hepatitis B, Chronic/*epidemiology/immunology/physiopathology
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Hepatitis C Antibodies/blood
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Hepatitis C, Chronic/*epidemiology/immunology/physiopathology
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Humans
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Korea
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Liver Function Tests
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Male
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Middle Aged
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Prevalence
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RNA, Viral/blood
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Retrospective Studies
2.Incidence of and risk factors for thyroid dysfunction during peginterferon alpha and ribavirin treatment in patients with chronic hepatitis C.
Yong HWANG ; Won KIM ; So Young KWON ; Hyung Min YU ; Jeong Han KIM ; Won Hyeok CHOE
The Korean Journal of Internal Medicine 2015;30(6):792-800
BACKGROUND/AIMS: Thyroid dysfunction (TD) is more likely to occur in patients with chronic hepatitis C (CHC) and is particularly associated with interferon (IFN) treatment. The purpose of this study was to investigate the incidence, outcomes, and risk factors for TD during pegylated interferon (PEG-IFN) and ribavirin (RBV) combined therapy in patients with CHC. METHODS: A total of 242 euthyroid patients with CHC treated with PEG-IFN/RBV were included. Thyroid function and autoantibodies were measured at baseline, and virologic response and thyroid function were assessed every 3 months during therapy. RESULTS: TD developed in 67 patients (27.7%) during the PEG-IFN/RBV treatment. The types of TD were subclinical hypothyroidism (50.7%), hypothyroidism (14.9%), thyroiditis (11.9%), subclinical hyperthyroidism (10.4%), and hyperthyroidism (10.4%). Most of the patients with TD recovered spontaneously; however, seven patients (10.4%) needed thyroid treatment. The sustained virological response rate was higher in patients with TD than those without (65.7% vs. 49.1%, p = 0.02). Baseline thyroid stimulating hormone (TSH) concentrations (odds ratio [OR], 2.09; 95% confidence interval [CI], 1.96 to 8.77; p < 0.001), presence of the thyroid peroxidase antibody (OR, 8.81; 95% CI, 1.74 to 44.6; p = 0.009), and PEG-IFNalpha-2b (OR, 3.01; 95% CI, 1.43 to 6.39; p = 0.004) were independent risk factors for the development of TD. CONCLUSIONS: TD developed in 27.7% of patients with CHC during PEG-IFN/RBV treatment, and 10.4% of these patients needed thyroid treatment. TD is associated with a favorable virologic response to PEG-IFN/RBV. Assessment of TSH and thyroid autoantibodies at baseline and close monitoring of thyroid function during PEG-IFN/RBV therapy are necessary for early detection and management of IFN-induced TD.
Adult
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Aged
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Antiviral Agents/*adverse effects
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Autoantibodies/blood
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Biomarkers/blood
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Drug Therapy, Combination
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Female
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Hepatitis C, Chronic/diagnosis/*drug therapy
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Humans
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Incidence
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Interferon-alpha/*adverse effects
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Male
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Middle Aged
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Polyethylene Glycols/*adverse effects
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Recombinant Proteins/adverse effects
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Republic of Korea
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Retrospective Studies
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Ribavirin/*adverse effects
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Thyroid Diseases/*chemically induced/diagnosis/epidemiology/immunology/physiopathology
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Thyroid Gland/*drug effects/immunology/physiopathology
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Time Factors
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Treatment Outcome