1.Diagnosis and management of pre-core mutant chronic hepatitis B.
Sung Won CHO ; Jae Youn CHEONG
Korean Journal of Medicine 2002;63(3):246-250
No abstract available.
Diagnosis*
;
Hepatitis B, Chronic*
;
Hepatitis, Chronic*
2.Diagnosis and management of pre-core mutant chronic hepatitis B.
Sung Won CHO ; Jae Youn CHEONG
Korean Journal of Medicine 2002;63(3):246-250
No abstract available.
Diagnosis*
;
Hepatitis B, Chronic*
;
Hepatitis, Chronic*
3.Clinical significance of hepatitis B virus genotypes in patients with acute viral hepatitis B
Journal of Practical Medicine 2005;512(5):40-43
In the study, 30 hepatitis B patients (23 males, 7 females, mean age 33.5 years) treated in Hue Central Hospital and the Hue Medical University Hospital from September 2004 to March 2005 were evaluated to find out the clinical significance of hepatitis B virus genotypes in acute viral hepatitis B. The results: 73.3% of the patients with common jaundice and 26.7% with long-term jaundice. The rate of HBeAg(+) in participants accounted for 43.3%. The rate of HBeAg(+) was similar between male and female. There were 8 patients with genotype B and 4 patients with genotype C. 25% of genotype B patients were female, while all of genotype C patients were male. The genotype C patients had jaundice period lasting more than 4 weeks. 80% of genotype B patients completely recovered and only 50% of patients became chronic disease. 100% of genotype C patients became chronic disease.
Hepatitis B virus
;
Genotype
;
Diagnosis
4.Analysis of Clinical Features and Hepatitis B Virus DNA Level in the Concomitant Cases of Hepatitis B Surface Antigen and Antibody.
Byung Ryul JEON ; Rojin PARK ; Jeong Won SHIN ; Tae Youn CHOI ; Hee Bong SHIN ; You Kyung LEE ; Young Jin CHOI ; Hwi Jun KIM ; Jee Young AHN
Korean Journal of Clinical Microbiology 2004;7(2):105-110
BACKGROUND: After an infection with HBV, HBsAg is the first virologic marker detectable in the serum. If anti-HBs against 'a'determinant of HBsAg appears, HBsAg will disappear and the patients will recover from the HBV infection in most cases. However, we encounter not infrequently concomitant cases of HBsAg and anti-HBs. In this study we evaluated HBV DNA levels in concomitant cases to aid in the interpretation of these serologic results. METHODS: This study included 36 cases with positivity for both HBsAg and anti-HBs in an electrochemiluminescent immunoassay as well as a radioimmunoassay. They were tested for HBeAg, anti-HBe, and HBV DNA levels. RESULTS: Chronic viral hepatitis was the most frequent diagnosis (15/36 : 41.7%) and AST and ALT levels were normal in 17 (47.2%) and 20 (55.6%) cases, respectively, among total 36 concomitant cases. HBeAg was positive in 24 and anti-HBe in 17 cases. HBV DNA was positive in 33 cases (91.7%). including all 24 HBeAg positive cases and 9 (75%) of 12 HBeAg negative cases; 6 (50%) of 12 HBeAg negative cases had HBV DNA levels higher than 105 copy/mL. CONCLUSIONS: This study showed that viral replication still exists in most cases of concomitant HBsAg and anti-HBs, and even in some HBeAg negative cases. So in the concomitant cases, HBV DNA quantitation may aid in the interpretation of clinical significance of these cases.
Diagnosis
;
DNA
;
Hepatitis B e Antigens
;
Hepatitis B Surface Antigens*
;
Hepatitis B virus*
;
Hepatitis B*
;
Hepatitis*
;
Humans
;
Immunoassay
;
Radioimmunoassay
6.Prevalence and Clinical Implications of Occult Hepatitis B Virus Infection.
The Korean Journal of Hepatology 2006;12(2):136-139
No abstract available.
Prevalence
;
Humans
;
Hepatitis B/*diagnosis/epidemiology/immunology
7.Establishment of confirmatory test for suspicious hepatitis B surface antigen positive samples.
Lin CHEN ; Yang RONG ; Jia LIU ; Jun XU ; Jing-Xia GUO ; Yong-Ji SONG ; Jing ZHAO ; Ai-Xia LIU ; Li-Hua YANG ; Bo-An LI ; Yuan-Li MAO
Chinese Journal of Experimental and Clinical Virology 2012;26(4):310-312
<b>OBJECTIVEb>Establish a confirmatory test based on ELISA, and use to verify the authenticity of HBsAg weak positive samples, pick and get rid of the false result, and avoid the mistake diagnosis.
<b>METHODb>The particles (reagent A) coated by streptavidin and biotinylated HBsAb (reagent B) were mixed in different proportions, then neutralized with serum whose the COI of HBsAg > 20 by ELISA in order to identify the activity of HBsAb in confirmatory reagent. 30 pieces of HBsAg weak positive serum neutralized with the confirmatory reagent, the serum were considered to be positive if rate of decline of HBsAg COI > 50%. The results were compared to Roche confirmatory Kit.
<b>RESULTb>Confirmatory reagent was able to neutralized with HBsAg. 24 of 30 pieces of HBsAg weak positive samples were judged to be positive, while 6 poeces were negative. The ELISA comfirm method is fully consistent with Roche confirmatory Kit.
<b>CONCLUSIONb>The ELISA confirmatory test for suspicious HBsAg positive samples is a simple, accurate and low cost initial validation method, After further clinical trials, should be widely applied.
Enzyme-Linked Immunosorbent Assay ; methods ; Hepatitis B ; blood ; diagnosis ; Hepatitis B Antibodies ; blood ; Hepatitis B Surface Antigens ; blood ; Humans
8.A case of dermatomyositis misdiagnosed as viral hepatitis B and D superinfection.
Wei-wei DAI ; Han-feng XU ; Yue-ping YAO
Chinese Journal of Hepatology 2007;15(9):717-717
Dermatomyositis
;
diagnosis
;
Diagnostic Errors
;
Hepatitis B
;
diagnosis
;
Hepatitis D
;
diagnosis
;
Humans
;
Male
;
Middle Aged
;
Superinfection
;
diagnosis
9.Mononeuropathy Multiplex in a Patient with Chronic Active Hepatitis B.
Tai Seung NAM ; Seung Han LEE ; Man Seok PARK ; Kang Ho CHOI ; Joon Tae KIM ; Seong Min CHOI ; Byeong Chae KIM ; Myeong Kyu KIM ; Ki Hyun CHO
Journal of Clinical Neurology 2010;6(3):156-158
BACKGROUND: Mononeuropathy multiplex is a rare complication during the course of chronic he-patitis B, despite various neuropathies following acute hepatitis B having been reported previously. CASE REPORT: A 30-year-old man presented with sensorimotor symptoms in multiple peripheral nerves. The serological tests for hepatitis were consistent with chronic active hepatitis B. After treatment with oral prednisone combined with an antiviral agent, the sensory and motor symptoms improved and hepatitis B virus replication was reduced. CONCLUSIONS: We suggest that chronic immune-mediated neuropathy associated with hepatitis B virus infection should be considered in the differential diagnosis of patients with hepatitis B.
Adult
;
Diagnosis, Differential
;
Hepatitis
;
Hepatitis B
;
Hepatitis B virus
;
Hepatitis B, Chronic
;
Hepatitis, Chronic
;
Humans
;
Mononeuropathies
;
Peripheral Nerves
;
Prednisone
;
Serologic Tests
10.Definition, Diagnosis, and Prevalence of Occult Hepatitis B Virus Infection.
The Korean Journal of Gastroenterology 2013;62(3):143-147
Occult HBV infection is characterized by the absence of serum HBsAg with persistence of low level of intrahepatic HBV DNA. Several suggested mechanisms for the origin of occult HBV infection include strong suppression of viral replication and gene expression, mutation in the regulatory regions of HBV genome, formation of immunoglobulin-bound HBsAg, viral interference, and blockage of HBsAg secretion from infected hepatocytes. Standardized assays are not yet available, and sensitive HBV DNA amplification assay is necessary for the diagnosis of cryptic infection. Detection rate of HBV DNA is highest in IgG anti-HBc positive population. However, neither anti-HBc nor anti-HBs can be detected in a significant proportion of infected persons. Occult HBV infection occurs in a number of clinical settings and is highly prevalent in HCV-infected patients as well as in patients with cryptogenic chronic liver disease including hepatocellular carcinoma.
DNA, Viral/analysis
;
Hepatitis B/*diagnosis/*epidemiology/metabolism
;
Hepatitis B Antibodies/blood
;
Hepatitis B Core Antigens/immunology
;
Hepatitis B Surface Antigens/blood
;
Humans