2.Occult hepatitis B virus infection.
Chang-yun CHEN ; Jian-rui WU ; Xin-yu ZHU ; Shuo-yi WANG
Chinese Journal of Hepatology 2005;13(11):873-875
3.Association between hepatitis B virus infection and risk of pancreatic cancer: a meta-analysis.
Han ZHUANG ; Zhipeng SHI ; Peng HU ; Hong REN ; Dazhi ZHANG
Chinese Journal of Hepatology 2014;22(6):416-419
<b>OBJECTIVEb>To investigate the relationship between hepatitis B virus (HBV) infection and risk of pancreatic cancer.
<b>METHODSb>Various English and Chinese language literature databases, including PubMed, Web of Knowledge, Embase, Cochrane Library and the Chinese National Knowledge Infrastructure, were searched for case-control studies comparing rates of HBV infection and pancreatic cancer. The RevMan meta analysis software, version 5.0, was used to perform the meta-analysis of the 6 included studies.
<b>RESULTSb>Compared with the control group, the pancreatic cancer group had a significantly higher rate of positivity for hepatitis B surface antigen (HBsAg) (8.87% vs.5.86%, odds ratio (OR) =1.24, 95% confidence interval (CI):1.06 to 1.47, P =0.009) and a lower rate of patients never exposed to HBV (defined as HBsAg(-)/hepatitis B core antibody (anti-HBc)(-) (69.4% vs.77.1%, OR =0.68, 95% CI:0.51 to 0.92, P =0.01). There was no significant difference between the two groups in the rate of hepatitis B e antigen positivity (P =0.55).
<b>CONCLUSIONb>HBV-infected patients with HBsAg(+) status are at greater risk of developing pancreatic cancer; however, since most of the research studies evaluated were conducted in Asians, the generalizability of this conclusion is unknown.
Hepatitis B ; epidemiology ; Hepatitis B Surface Antigens ; blood ; Hepatitis B virus ; Humans ; Pancreatic Neoplasms ; epidemiology ; virology ; Risk Factors
4.Epidemiological distribution of genotypes and sub-genotypes of hepatitis B virus in 15 ethnic groups in China.
Xiao Qi GUO ; Shuang ZHANG ; Hui ZHENG ; Feng WANG ; Ning MIAO ; Qiu Dong SU ; Sheng Li BI ; Guo Min ZHANG ; Fu Zhen WANG ; Li Ping SHEN
Chinese Journal of Epidemiology 2023;44(5):759-764
Objective:b> To understand the distribution of genotypes and sub-genotypes of HBV in different ethnic groups in China. Methods:b> The HBsAg positive samples were selected by stratified multi-stage cluster sampling from the sample base of national HBV sero-epidemiological survey in 2020 for the amplification of S gene of HBV by nested PCR. A phylogeny tree was constructed to determine the genotypes and sub-genotypes of HBV. The distribution of genotypes and sub-genotypes of HBV were analyzed comprehensively by using laboratory data and demographic data. Results:b> A total of 1 539 positive samples from 15 ethnic groups were successfully amplified and analyzed, and 5 genotypes (B, C, D, I and C/D) were detected. The proportion of genotype B was higher in ethnic group of Han (74.52%, 623/836), Zhuang (49.28%, 34/69), Yi (53.19%, 25/47), Miao (94.12%, 32/34), Buyi (81.48%, 22/27). The proportions of genotype C were higher in ethnic groups of Yao (70.91%, 39/55). Genotype D was the predominant genotype in Uygur (83.78%, 31/37). Genotype C/D were detected in Tibetan (92.35%,326/353). In this study, 11 cases of genotype I were detected, 8 of which were distributed in Zhuang nationality. Except for Tibetan, sub-genotype B2 accounted for more than 80.00% in genotype B in all ethnic groups. The proportions of sub-genotype C2 were higher in 8 ethnic groups, i.e. Han, Tibetan, Yi, Uygur, Mongolian, Manchu, Hui and Miao. The proportions of sub-genotype C5 were higher in ethnic groups of Zhuang (55.56%, 15/27) and Yao (84.62%, 33/39). For genotype D, sub-genotype D3 was detected in Yi ethnic group and sub-genotype D1 was detected in both Uygur and Kazak. The proportions of sub-genotype C/D1 and C/D2 in Tibetan were 43.06% (152/353) and 49.29% (174/353). For all the 11 cases of genotype I infection, only sub-genotype I1 was detected. Conclusions:b> Five genotypes and 15 sub-genotypes of HBV were found in 15 ethnic groups. There were significant differences in the distribution of genotypes and sub-genotypes of HBV among different ethnic groups.
Humans
;
Asian People
;
China/epidemiology*
;
Ethnicity
;
Genotype
;
Gerbillinae
;
Hepatitis B virus/genetics*
;
Hepatitis B/virology*
5.Preliminary study on genotype of hepatitis B virus detected from Tibetans in China.
Yan-qing XU ; Yong-dong ZHOU ; Sheng-li BI
Chinese Journal of Experimental and Clinical Virology 2005;19(2):118-120
<b>OBJECTIVEb>To determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention.
<b>METHODSb>The S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3.
<b>RESULTSb>In trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C.
<b>CONCLUSIONb>The dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.
Genotype ; Hepatitis B ; blood ; epidemiology ; virology ; Hepatitis B Core Antigens ; genetics ; Hepatitis B Surface Antigens ; blood ; genetics ; Hepatitis B virus ; classification ; genetics ; immunology ; Humans ; Phylogeny ; Tibet ; epidemiology
6.Analysis of suspected hepatitis B virus genotype I from one patient in Guizhou province.
Xing-lin YANG ; Hai HUANG ; Yi-guang WANG ; Yong-fu LI ; Jie TIAN
Chinese Journal of Hepatology 2012;20(7):545-546
Adult
;
China
;
epidemiology
;
Genes, Viral
;
Genotype
;
Hepatitis B
;
epidemiology
;
virology
;
Hepatitis B virus
;
classification
;
genetics
;
isolation & purification
;
Humans
;
Male
7.Molecular epidemiological study of occult hepatitis B virus infection in hemodialysis patients.
Lei JIN ; Zhen-hua ZHANG ; Yu DAI ; Ya-fei ZHANG ; Li-zhou ZHANG ; Xu LI
Chinese Journal of Hepatology 2010;18(12):937-939
Adult
;
Aged
;
Female
;
Genotype
;
Hepatitis B
;
epidemiology
;
genetics
;
virology
;
Hepatitis B virus
;
Humans
;
Male
;
Middle Aged
;
Molecular Epidemiology
;
Renal Dialysis
8.Explore the relationship between HBV genotypes and differentiation of hepatocellular carcinoma.
Dao-bing ZENG ; Shi-chun LU ; Wei LAI ; Jun DAI ; Ju-shan WU
Chinese Journal of Hepatology 2009;17(8):622-623
Adult
;
Carcinoma, Hepatocellular
;
epidemiology
;
pathology
;
virology
;
DNA, Viral
;
blood
;
genetics
;
Female
;
Genotype
;
Hepatitis B
;
epidemiology
;
virology
;
Hepatitis B Surface Antigens
;
blood
;
Hepatitis B virus
;
genetics
;
Humans
;
Liver Neoplasms
;
epidemiology
;
pathology
;
virology
;
Male
;
Middle Aged
;
Neoplasm Staging
;
Polymerase Chain Reaction
;
methods
9.Recent Etiology and Clinical Features of Acute Viral Hepatitis in a Single Center of Korea.
Hyung Min KANG ; Sook Hyang JEONG ; Jin Wook KIM ; Donhun LEE ; Chang Kyu CHOI ; Young Soo PARK ; Jin Hyuk HWANG ; Nayoung KIM ; Dong Ho LEE
The Korean Journal of Hepatology 2007;13(4):495-502
BACKGROUND AND AIMS: The etiology of acute viral hepatitis in Korea has been dynamically changing during the recent years. The aim of this study was to investigate the recent etiology and the clinical features of acute viral hepatitis in a single center of Korea. METHODS: We performed a retrospective analysis of a prospective cohort of 55 patients who were diagnosed with acute viral hepatitis A to E during the period from May 2005 to August 2006. In addition to the clinically acute manifestations, the confirmatory serological tests were performed for the diagnosis of acute hepatitis A, B, C and E. RESULTS: The proportion of patients with acute viral hepatitis A, B, C, E and others were 56.4% (n=31), 12.7% (n=7), 18.2% (n=10), 9.1% (n=5) and 3.6% (n=2), respectively. The mean age of the patients with acute hepatitis A, B, C and E were 29.1+/-4.38, 38.7+/-11.72, 45.3+/-17.62 and 32.4+/-6.58 years, respectively. There was no fatal case. All cases of acute hepatitis B and six out of ten cases of acute hepatitis C recovered spontaneously. Four out of the five patients with acute hepatitis E had no history of travel to endemic area. CONCLUSIONS: The most common etiology of acute viral hepatitis in Korea is hepatitis A virus, and hepatitis C and B virus were the next most common causes. The sporadic cases of acute hepatitis E were not rare, and coinfection of HAV and HEV was observed. A multicenter, prospective study is warranted in the future.
Acute Disease
;
Adult
;
Aged
;
Cohort Studies
;
Female
;
Hepatitis A/diagnosis/epidemiology/virology
;
Hepatitis B/diagnosis/epidemiology/virology
;
Hepatitis C/diagnosis/epidemiology/virology
;
Hepatitis D/diagnosis/epidemiology/etiology
;
Hepatitis E/diagnosis/epidemiology/virology
;
Hepatitis Viruses/isolation & purification
;
Hepatitis, Viral, Human/*diagnosis/epidemiology/*virology
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Retrospective Studies
10.Analysis of hepatitis virus infection in hepatocellular carcinoma patients receiving surgical operation in China and Japan.
Ping YUAN ; Wei TANG ; Jin WEN ; Qian-ming LI ; Hua LUO ; Bo-heng LIANG ; Qing-ming ZHENG ; Li WEI
Chinese Journal of Preventive Medicine 2005;39(5):332-334
<b>OBJECTIVEb>To describe and compare the hepatitis virus infection in hepatocellular carcinoma (HCC) patients receiving surgical operation in China and Japan.
<b>METHODSb>Information of surgical HCC patients was retrieved from the medical records. The concerned characteristics of the HCC cases from two countries were described and compared.
<b>RESULTSb>A total of 425 diagnosed cases that underwent surgical resection for HCC in China were investigated, and the corresponding cases in Japan were 247. The proportion of the hepatitis virus infection was 75.53% in patients with HCC from China. Within the infection cases, 91.28% were positive for HBsAg but negative for anti-HCV. The proportion was 82.59% in patients with HCC from Japan. Within the infection cases, 77.94% were positive for anti-HCV but negative for HBsAg. The proportion of hepatocirrhosis in the hepatitis virus infection patients with HCC were 89.10% and 68.14% in China and Japan, respectively.
<b>CONCLUSIONb>The hepatitis B virus infection showed be a main cause of HCC in China, however, the HCC in Japan be mostly related to hepatitis C virus infection.
Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular ; epidemiology ; surgery ; virology ; Child ; China ; epidemiology ; Female ; Hepacivirus ; immunology ; Hepatitis B ; epidemiology ; virology ; Hepatitis B Surface Antigens ; blood ; Hepatitis B virus ; immunology ; Hepatitis C ; epidemiology ; virology ; Hepatitis C Antigens ; blood ; Humans ; Japan ; epidemiology ; Liver Neoplasms ; epidemiology ; surgery ; virology ; Male ; Middle Aged ; Sex Distribution ; Young Adult