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<b>METHODSb>A total of 1214 serum samples from patients with chronic HBV infection were collected in 11 cities of China, including Beijing, Qingyuan, Shenzhen, Shijiazhuang, Hanchuan, Nanjing, Changchun, Liaocheng, Jinan, Ningbo and Wenzhou. Genotypes of the 1214 HBV strains were identified by PCR method with type specific primers. Parts of the results were confirmed by direct sequencing analysis of PCR products.

<b>RESULTSb>Among the 1214 patients with chronic HBV infection, 0.7% (9/1214)were genotype A, 28.4% (345/1214)genotype B, 58.4% (709/1214) genotype C, and 12.4% (151/1214) genotype B and genotype C mixed infection. No other genotypes were found. Genotype C was predominant in the northern part of China, such as Changchun, Beijing, Shijiazhuang,while genotype B was more commonly seen in south of China. 71.4% (20/28) for patients from Qingyuan and 63.6% (70/110) from Shenzhen were infected with genotype B.

<b>CONCLUSIONb>HBV genotypes had distinct geographic distribution. Genotype B and C the predominant strains in patients with chronic HBV infection in China. Genotype C was predominantly identified in the northern part of China versus genotype B the south.

China ; epidemiology ; Genotype ; Geography ; Hepatitis B virus ; genetics ; Hepatitis B, Chronic ; epidemiology ; Humans ; Polymerase Chain Reaction

7.Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B.

Da-Zhi ZHANG

Chinese Journal of Hepatology 2007;15(11):876-877

8.Relationships of HBV genotypes and HBV lymphocytes and clinical features of chronic hepatitis B patients.

Xi-bing GU ; Xiang-hu JIANG ; Yue-ming JIANG ; Dong WANG ; Zhong HUA ; Hang-yuan WU ; Hao-kun CHEN ; Yue-qin XU ; Zhong-hua LU

Chinese Journal of Hepatology 2008;16(9):700-701

9.The study of correlation between distribution of hepatitis B virus genotypes and clinical character in Jiangxi province.

Long XU ; Da-ping CHE ; Ding-ying LÜ ; Nan XIE ; Zhi-cheng ZHANG ; Chun-teng LU ; Gang QIAN ; Ying-qing WAN ; Guo-wei WU ; Xiang-lin TU

Chinese Journal of Hepatology 2006;14(2):147-148

10.Regulation of HBV transcription and replication and severe acute exacerbation of chronic hepatitis B.

Hong TANG ; En-qiang CHEN

Chinese Journal of Hepatology 2010;18(4):243-245

1.Progression on molecular targets associated with severe acute exacerbation of chronic hepatitis B.

2.Should both patient's age and family history be necessary as the criteria for initiating treatment of HBeAg-positive or negative patients with chronic hepatitis B virus infection and normal alanine aminotransferase?

3.Non-reproducible results in genetic association studies in chronic hepatitis B due to the inadequate controls.

4.The responses of HBcAg specific CTL to HBV/C variants.

5.Age and family history are both not required for initiation of antiviral therapy in patients with chronic hepatitis B.

6.Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B virus infection among 12 cities in China.

7.Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B.

8.Relationships of HBV genotypes and HBV lymphocytes and clinical features of chronic hepatitis B patients.

9.The study of correlation between distribution of hepatitis B virus genotypes and clinical character in Jiangxi province.

10.Regulation of HBV transcription and replication and severe acute exacerbation of chronic hepatitis B.

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