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<b>OBJECTIVEb>To investigate the distribution of Hepatitis B virus genotypes and subgenotypes among patients with chronic hepatitis B in Xinjiang Uighur.

<b>METHODSb>The HBV genotypes and subgenotypes were analyzed by PCR-restriction fragment length polymorphism in 109 patients with chronic hepatitis B.

<b>RESULTSb>Two HBV genotypes, genotype C (45.9%) and genotype C/D (29.4%) were prevalent, genotype B (8.3%) and genotype D (16.5%) were also found in Xinjiang Uighur. Genotype C had two subgenotypes, C1 (54%) and C2 (46%). Genotype B had only one subgenotype, i.e. Ba. The subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.

<b>CONCLUSIONb>In Uygurs, the most common HBV genotypes were C and C/D, and the subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.

Carcinoma, Hepatocellular ; virology ; Genotype ; Hepatitis B virus ; genetics ; Hepatitis B, Chronic ; virology ; Humans ; Liver Neoplasms ; virology

8.Regulation of HBV transcription and replication and severe acute exacerbation of chronic hepatitis B.

Hong TANG ; En-qiang CHEN

Chinese Journal of Hepatology 2010;18(4):243-245

9.Relationships of HBV genotypes and HBV lymphocytes and clinical features of chronic hepatitis B patients.

Xi-bing GU ; Xiang-hu JIANG ; Yue-ming JIANG ; Dong WANG ; Zhong HUA ; Hang-yuan WU ; Hao-kun CHEN ; Yue-qin XU ; Zhong-hua LU

Chinese Journal of Hepatology 2008;16(9):700-701

10.Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B.

Da-Zhi ZHANG

Chinese Journal of Hepatology 2007;15(11):876-877

1.Progression on molecular targets associated with severe acute exacerbation of chronic hepatitis B.

2.Should both patient's age and family history be necessary as the criteria for initiating treatment of HBeAg-positive or negative patients with chronic hepatitis B virus infection and normal alanine aminotransferase?

3.Non-reproducible results in genetic association studies in chronic hepatitis B due to the inadequate controls.

4.The responses of HBcAg specific CTL to HBV/C variants.

5.Age and family history are both not required for initiation of antiviral therapy in patients with chronic hepatitis B.

6.The study of correlation between distribution of hepatitis B virus genotypes and clinical character in Jiangxi province.

7.Distribution of hepatitis B virus genotypes and subgenotypes among chronically infected patients in Xinjiang Uighur..

8.Regulation of HBV transcription and replication and severe acute exacerbation of chronic hepatitis B.

9.Relationships of HBV genotypes and HBV lymphocytes and clinical features of chronic hepatitis B patients.

10.Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B.

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