7.Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B virus infection among 12 cities in China.
Jun-wei GAO ; Ya-juan LI ; Hui ZHUANG ; Jie LI ; Jia WANG ; Qing-ming DONG ; Ya-jie CHEN ; Jun-qi NIU ; Wei-Min MA ; Wei ZHAO ; Bao-an ZHAO ; Jin-qun ZHONG
Chinese Journal of Epidemiology 2007;28(4):315-318
<b>OBJECTIVEb>To investigate the distribution of hepatitis B virus (HBV) genotypes in patients with chronic HBV infection among 11 cities of China.
<b>METHODSb>A total of 1214 serum samples from patients with chronic HBV infection were collected in 11 cities of China, including Beijing, Qingyuan, Shenzhen, Shijiazhuang, Hanchuan, Nanjing, Changchun, Liaocheng, Jinan, Ningbo and Wenzhou. Genotypes of the 1214 HBV strains were identified by PCR method with type specific primers. Parts of the results were confirmed by direct sequencing analysis of PCR products.
<b>RESULTSb>Among the 1214 patients with chronic HBV infection, 0.7% (9/1214)were genotype A, 28.4% (345/1214)genotype B, 58.4% (709/1214) genotype C, and 12.4% (151/1214) genotype B and genotype C mixed infection. No other genotypes were found. Genotype C was predominant in the northern part of China, such as Changchun, Beijing, Shijiazhuang,while genotype B was more commonly seen in south of China. 71.4% (20/28) for patients from Qingyuan and 63.6% (70/110) from Shenzhen were infected with genotype B.
<b>CONCLUSIONb>HBV genotypes had distinct geographic distribution. Genotype B and C the predominant strains in patients with chronic HBV infection in China. Genotype C was predominantly identified in the northern part of China versus genotype B the south.
China ; epidemiology ; Genotype ; Geography ; Hepatitis B virus ; genetics ; Hepatitis B, Chronic ; epidemiology ; Humans ; Polymerase Chain Reaction
8.The study of correlation between distribution of hepatitis B virus genotypes and clinical character in Jiangxi province.
Long XU ; Da-ping CHE ; Ding-ying LÜ ; Nan XIE ; Zhi-cheng ZHANG ; Chun-teng LU ; Gang QIAN ; Ying-qing WAN ; Guo-wei WU ; Xiang-lin TU
Chinese Journal of Hepatology 2006;14(2):147-148
China
;
Female
;
Genotype
;
Hepatitis B virus
;
genetics
;
Hepatitis B, Chronic
;
virology
;
Humans
;
Male
9.Distribution of hepatitis B virus genotypes and subgenotypes among chronically infected patients in Xinjiang Uighur..
Xiao-Feng SUN ; Shu-Juan WEN ; Hui LI ; Jin-Lin HOU ; Yue-Xin ZHANG ; Zhan-Hui WANG ; Yu-Jian ZHENG
Chinese Journal of Hepatology 2009;17(2):88-90
<b>OBJECTIVEb>To investigate the distribution of Hepatitis B virus genotypes and subgenotypes among patients with chronic hepatitis B in Xinjiang Uighur.
<b>METHODSb>The HBV genotypes and subgenotypes were analyzed by PCR-restriction fragment length polymorphism in 109 patients with chronic hepatitis B.
<b>RESULTSb>Two HBV genotypes, genotype C (45.9%) and genotype C/D (29.4%) were prevalent, genotype B (8.3%) and genotype D (16.5%) were also found in Xinjiang Uighur. Genotype C had two subgenotypes, C1 (54%) and C2 (46%). Genotype B had only one subgenotype, i.e. Ba. The subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
<b>CONCLUSIONb>In Uygurs, the most common HBV genotypes were C and C/D, and the subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
Carcinoma, Hepatocellular ; virology ; Genotype ; Hepatitis B virus ; genetics ; Hepatitis B, Chronic ; virology ; Humans ; Liver Neoplasms ; virology
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