Budd-Chiari Syndrome ; complications ; Hepatitis ; complications ; Humans

Hepatitis B virus (HBV) infection is an important public health concern, as approximately 3.5% of the world's population is currently chronically infected. Chronic HBV infection is the primary cause of cirrhosis, hepatocellular carcinoma, and deaths related to liver disease globally. Studies have found that in HBV infection, viruses can directly or indirectly regulate mitochondrial energy metabolism, oxidative stress, respiratory chain metabolites, and autophagy, thereby altering macrophage activation status, differentiation types, and related cytokine secretion type and quantity regulations. Therefore, mitochondria have become an important signal source for macrophages to participate in the body's immune system during HBV infection, providing a basis for mitochondria to be considered as a potential therapeutic target for chronic hepatitis B.
Humans ; Hepatitis B virus/physiology* ; Hepatitis B/complications* ; Hepatitis B, Chronic/complications* ; Mitochondria ; Liver Neoplasms ; Macrophages

Fatty Liver ; complications ; epidemiology ; Hepatitis B, Chronic ; complications ; epidemiology ; Hepatitis C, Chronic ; complications ; epidemiology ; Humans

Auto-immune hepatitis is a chronic necroinflammatory liver disorder that is characterized by hypergammaglobulinemia, auto-antibodies in serum, and, on histological examination, the presence of periportal hepatitis. Although it can be associated with a number of other auto-immune diseases, Sjogren's syndrome is rarely associated with auto-immune hepatitis. We herein report an unusual case of auto-immune hepatitis associated with primary Sjogren's syndrome. A 39-year-old woman was admitted to our hospital due to jaundice. Laboratory data showed negative viral hepatitis marker, increased serum IgG level, positive anti- nuclear antibody, and an increased rheumatoid factor titer. The patient had no history of taking medications and alcohol. Based on characteristic clinical features, liver biopsy findings, positive Schirmer's test, and salivary scintigraph, she was diagnosed as having auto-immune hepatitis and Sjogren's syndrome. The patient achieved complete remission with steroid monotherapy.
Adult ; Hepatitis, Autoimmune/*complications/diagnosis ; Humans ; Sjogren's Syndrome/*complications/diagnosis

Animals ; HIV Infections ; complications ; therapy ; Hepatitis B ; complications ; therapy ; Humans

Consensus ; Hepatitis B ; complications ; Humans ; Lymphoma ; complications ; virology

Female ; Hepatitis C, Chronic ; complications ; Humans ; Hypopituitarism ; complications ; Middle Aged

Adult ; Hepatitis, Viral, Human ; complications ; Histiocytic Sarcoma ; complications ; Humans ; Male

Adult ; Aspergillosis ; complications ; Female ; Hepatitis B, Chronic ; complications ; Hepatitis, Viral, Human ; complications ; Humans ; Lung Diseases, Fungal ; complications ; Male ; Middle Aged

Genotype ; Hepacivirus ; genetics ; physiology ; Hepatitis B ; complications ; Hepatitis B virus ; Hepatitis C ; complications ; Humans ; RNA, Viral ; analysis