Adult ; Hepatitis, Viral, Human ; complications ; Histiocytic Sarcoma ; complications ; Humans ; Male

Diabetes Mellitus ; etiology ; Hepatitis, Viral, Human ; complications ; Humans ; Insulin Resistance

Hepatitis, Viral, Human ; complications ; Humans ; Thrombocytopenia ; etiology ; therapy

Adult ; Aspergillosis ; complications ; Female ; Hepatitis B, Chronic ; complications ; Hepatitis, Viral, Human ; complications ; Humans ; Lung Diseases, Fungal ; complications ; Male ; Middle Aged

OBJECTIVETo confirm the close relationship of high co-infection rate between HIV and hepatitis virus in intravenous drug users (i.v.DUs).

METHODSAnti-HIV, HBV and HCV were detected by ELISA in the serum from 35 scattered and 15 massed i.v.DUs. PCR and RT-PCR were performed to confirm the infection of HIV, HBV, HCV, HGV and TTV among the 15 massed intravenous drug abusers.

RESULTSAmong the 50 i.v.DUs, the positive rates of anti-HCV1 HBsAg, anti-HBe and anti-HBc were 92% (46/50), 12% (6/50), 10% (5/50) and 66% (33/50), respectively. In the samples of HBsAg positive, their HBeAg was also positive. Although the positive rate of serum markers was different in the massed i.v.DUs compared to the scattered i.v.DUs, no significant difference was shown. In the cases of massed i.v.DUs, the positive rates of HIV DNA, HBV-DNA, HCV-RNA, HGV-RNA, and TTV-DNA were 100% (15/15), 26.6% (4/15), 53.3% (8/15), 33.3% (5/15) and 26.6% (4/15), respectively. Among the 15 massed intravenous drug users, one was infected with HIV, HBV, HCV, HGV and TTV; two were infected with HIV, HBV, HCV and HGV; three were infected only with HIV; and the remaining had other forms of co-infection.

CONCLUSIONThe co-infection rate of HIV, HBV, HCV, HGV and TTV in intravenous drug users is very high.

HIV Infections ; complications ; Hepatitis, Viral, Human ; complications ; Humans ; Substance Abuse, Intravenous ; complications

Hepatitis, Viral, Human ; complications ; surgery ; Humans ; Liver Cirrhosis ; etiology ; surgery ; Liver Failure ; surgery ; Liver Transplantation

Alcoholism ; complications ; China ; Congresses as Topic ; Fatty Liver ; epidemiology ; etiology ; Hepatitis, Viral, Human ; complications ; Humans ; Metabolic Syndrome ; complications ; Risk Factors

OBJECTIVETo study the pathogenic effect of hepatitis G virus (HGV) infection on hepatic failure.

METHODSUsing the RT-PCR and EIA techniques to detect HGV RNA and anti-HGV in sera of hepatic failure patients and compare them with their liver function and mortality rates.

RESULTSThere was no significant difference about the positive rates of HGV among acute hepatic failure, subacute hepatic failure and chronic hepatic failure groups (X(2)=2.54, P>0.05). The level of ALT in HGV-positive group was slightly lower than that in HGV-negative group. The concentration of bilirubin and globulin was higher in HGV-positive group than HGV-negative group, and the concentration of albumin in HGV-positive group was significantly lower than that in HGV-negative group (t=2.59, P<0.05). The mortality rate in HGV-positive group was significantly lower than that in HGV-negative group (X(2)=4.68, 0.01

CONCLUSIONSThe virulence of HGV is mild, and the HGV infection does not aggravate hepatic failure.

Adult ; Female ; Flaviviridae Infections ; complications ; GB virus C ; pathogenicity ; Hepatitis, Viral, Human ; complications ; Humans ; Liver Failure ; etiology ; Male ; Middle Aged

OBJECTIVETo discuss features of onset of chronic severe viral hepatitis (CSH).

METHODSThe patterns of onset of 520 cases of CSH were analyzed by SPASS and STATA software.

RESULTS1. Within less than 10 days, less than 2 weeks, 2 to 4 weeks, 4 weeks to 6 months, 10.4%, 18.1%, 17.1% and 64.8% of 520 cases deteriorated into severe hepatitis respectively. 2. There were no definite predisposing factors in more than 40% cases. There were 1 to 3 or more predisposing factors in more than 30% cases. The incidence of concurrent infection was the highest (P<0.01). 3. The pathogenic basis in more than 50% cases was cirrhosis. 4. Hepatic encephalopathy did not occur in more than 50% of the cases. Ascites occurred in more than 75% of cases. Hepatic encephalopathy first occurred in less than 5% cases and ascites in more than 10% of cases. 5. The latest time for occurrence of hepatic encephalopathy was later than the time of deteriorating into severe hepatitis.

CONCLUSIONS1. Gradual deterioration into CSH was found in all the 520 cases. 2. The predisposing factors, pathogenic bases, incidence and occurring time of hepatic encephalopathy, firstly occurring complication and so on in CSH are not the same as those in acute and subacute severe hepatitis. Therefore, CSH should be independently named and the study of CSH should be strengthened.

Adolescent ; Adult ; Aged ; Ascites ; etiology ; Child ; Female ; Hepatic Encephalopathy ; etiology ; Hepatitis, Chronic ; complications ; Hepatitis, Viral, Human ; complications ; Humans ; Liver Cirrhosis ; etiology ; Male ; Middle Aged ; Prospective Studies

Adolescent ; Adult ; Aged ; Alanine Transaminase ; blood ; Aspartate Aminotransferases ; blood ; DNA, Viral ; blood ; genetics ; Female ; Hepatitis B virus ; genetics ; Hepatitis B, Chronic ; blood ; complications ; pathology ; Hepatitis, Viral, Human ; complications ; virology ; Humans ; Male ; Middle Aged ; Severity of Illness Index