1.Clinical characteristics of 159 cases of acute toxic hepatitis.
Sun Hyung KANG ; Jeong Il KIM ; Kyung Hye JEONG ; Kwang Hoon KO ; Pyung Gohn KO ; Se Woong HWANG ; Eun Mi KIM ; Seok Hyun KIM ; Heon Young LEE ; Byung Seok LEE
The Korean Journal of Hepatology 2008;14(4):483-492
BACKGROUNDS/AIMS: Toxic hepatitis has recently been discovered to be a major cause of acute hepatitis. We studied the clinical features and prognosis of patients diagnosed with toxic hepatitis at a single institution. METHODS: A retrospective analysis was performed using medical records of 159 cases of toxic hepatitis that were diagnosed from March 2003 to March 2008. Patients were selected based on a RUCAM score of 4 or above. RESULTS: The incidence was higher in women (n=97) than in men (n=62). The age (mean+/-SD) of the patients was 51+/-15 years . The major causes of the disease included the use of Korean traditional therapeutic preparations (34.0%), herbal medicines (41.5%), and drugs prescribed by a physician (23.9%). At the time of admission, jaundice was the most common symptom (41.5%), and the results of a liver serum battery were as follows: aspartate aminotransferase, 729.4+/-877.0 IU/L; alanine aminotransferase, 857.1+/-683.0 IU/L; total bilirubin, 6.4+/-6.5 mg/dL; and alkaline phosphatase, 209.8+/-130.0 IU/L. The hospitalization period was 10.0+/-9.5 days, and the duration of recovery from liver injury was 31.0+/-29.5 days. The factors associated with the hospitalization period included the presence of anorexia and the serum levels of albumin and bilirubin at the time of admission (P<0.05). A high serum bilirubin level and a history of alcohol ingestion were associated with a delayed recovery (Plt;0.05). The sex, age, BMI, and duration of medication were not significantly related to the hospitalization and recovery periods. CONCLUSIONS: The main cause of acute toxic hepatitis in the current study was the use of herbal medicines. The severity of liver injury at the time of admission was a major factor significantly associated with the hospitalization and recovery periods.
Acute Disease
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Alcohol Drinking
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Bilirubin/blood
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Drugs, Chinese Herbal
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Female
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Hepatitis, Toxic/*diagnosis/epidemiology/etiology
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Humans
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Length of Stay
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Male
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Medical Records
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Middle Aged
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Prognosis
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Retrospective Studies
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Risk Factors
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Severity of Illness Index