1.Indication of Drug Therapy in Patients with Chronic Hepatitis B.
The Korean Journal of Hepatology 2005;11(1):1-8
No abstract available.
Hepatitis B, Chronic/*drug therapy
;
Humans
2.Advances in new antivirals for chronic hepatitis B.
Yanhua TANG ; Hongyan LIANG ; Ge ZENG ; Sheng SHEN ; Jian SUN
Chinese Medical Journal 2022;135(5):571-583
Chronic hepatitis B virus (HBV) infection remains a global health burden. Timely and effective antiviral therapy is beneficial for patients with HBV infection. With existing antiviral drugs, including nucleos(t)ide analogs and interferon-alfa, patients can achieve viral suppression with improved prognosis. However, the rate of hepatitis B surface antigen loss is low. To achieve a functional cure and even complete cure in chronic hepatitis B patients, new antivirals need to be developed. In this review, we summarized the advantages and disadvantages of existing antiviral drugs and focused on new antivirals including direct-acting antiviral drugs and immunotherapeutic approaches.
Antiviral Agents/therapeutic use*
;
Hepatitis B/drug therapy*
;
Hepatitis B Surface Antigens
;
Hepatitis B virus
;
Hepatitis B, Chronic/drug therapy*
;
Hepatitis C, Chronic/drug therapy*
;
Humans
4.Mechanism and clinical significance of HBV reactivation after anti-HCV therapy.
Wan Jia ZENG ; Lin GAO ; Yi Wei XU ; Xiang Mei CHEN ; Fu Sheng WANG ; Feng Min LU
Chinese Journal of Hepatology 2022;30(9):997-1001
Direct-acting antivirals (DAAs) can strongly inhibit the replication of hepatitis C virus (HCV) and effectively clear the infection, but it may cause hepatitis B virus (HBV) reactivation, leading to severe liver damage and fulminate hepatitis in patients with HCV/HBV coinfection. In this review, we summarized the different replication process of HCV and HBV in infected hepatocytes and consequent innate immune response, and then discussed the molecular mechanism and clinical significance of HBV reactivation, and put forward the clinical precaution.
Humans
;
Hepatitis B virus
;
Hepacivirus
;
Antiviral Agents/pharmacology*
;
Hepatitis C, Chronic/drug therapy*
;
Virus Activation
;
Hepatitis C/drug therapy*
;
Coinfection/drug therapy*
;
Hepatitis B/drug therapy*
5.Management of Chronic Hepatitis B.
The Korean Journal of Hepatology 2007;13(4):447-488
No abstract available.
Antiviral Agents/therapeutic use
;
Hepatitis B, Chronic/*drug therapy
;
Humans
6.Dose and Treatment Duration of Regimen.
The Korean Journal of Hepatology 2005;11(1):13-16
No abstract available.
Antiviral Agents/administration & dosage
;
Hepatitis B, Chronic/*drug therapy
;
Humans
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