Hepatitis, Alcoholic ; Humans

No abstract available.
Middle Aged ; Male ; Liver/*pathology ; Humans ; Hepatitis, Alcoholic/*pathology

BACKGROUND: Iron is essential for life, but iron overload state cause potentially fatal health risk. There is growing evidence that only mildly increased amounts of hepatic iron can be damaging, particulary if combined with other hepatotoxic factors such as alcoholic or chronic viral hepatits B,C. The aim of this study was to assess the serum iron status of patients with various forms of hepatitis and cirrhosis of liver and to determine the correlation between the degree of hepatocyte damage (expressed as ALT activity) and status of serum iron parameters. METHODS: Our research involved 107 patients (69 male ranging in age from 27-67 and 38 female ranging in age from 32-62) diagnosed with chronic viral hepatitis B or type C, alcoholic hepatitis or cirrhosis of the liver. Serum iron parameters such as serum iron, ferritin, TIBC, and aminotransferase measured as necroinflammatory activity in Chronic hepatitis. RESULTS: There was no difference s-iron level between chronic hepatitis and cirrhosis but, significantly higher in alcoholic hepatitis and cirrhosis than viral hepatitis and cirrhosis respectively. s-Ferritin level was significantly higher in cirrhosis than hepatits group, and more higher in alcoholic hepatitis and cirrhosis than viral hepatitis and cirrhosis respectively. In chronic hepatitis groups, there are significant correlation between ALT and s-ferritin level regardness of etiology. CONCLUSION: Serum iron overload state was prominent in alcoholic hepatitis and cirrhosis than viral hepatitis and cirrhosis. High serum ferritin level can predict hepatocyte damage in chronic hepatitis.
Alcoholics ; Female ; Ferritins ; Fibrosis ; Hepatitis ; Hepatitis B ; Hepatitis, Alcoholic ; Hepatitis, Chronic ; Hepatocytes ; Humans ; Iron Overload ; Iron* ; Liver Diseases* ; Liver* ; Male

Adolescent ; Adult ; Child ; Diagnosis, Differential ; Fatty Liver ; diagnosis ; pathology ; Female ; Hepatitis ; diagnosis ; pathology ; Hepatitis, Alcoholic ; diagnosis ; Humans ; Male ; Middle Aged

We report two cases of benign symmetrical lipornatosis, one associated with mild hyperthyroidism in a 57-year-old man and the other with alcoholic hepatitis in a 57-year-old man. In the histologic exsmination of the excised mass we found fibrous pseudocapsules surrounding adipose tissue in case 1, but not in case 2. Liposuction was performed in case 1 and simple excision in case 2 for treatment of tumors. The tumor masses were not recurred in clinical observation for follow-up 5 months after treatment.
Adipose Tissue ; Follow-Up Studies ; Hepatitis, Alcoholic ; Humans ; Hyperthyroidism ; Lipectomy ; Lipomatosis* ; Middle Aged

Dimethylformamide (DMF) is a major solvent predominately used in synthetic leather and electrical equipment production. The effects of DMF exposure in humans are not well known or documented in the medical literature. We present a case of an electrical factory worker who underwent frequent exposure to DMF while making film. The patient complained of abdominal pain, nausea, vomiting and presented with hepatotoxicity serologic evaluation consistent with prior reports in people exposed to DMF. The possibility of viral, drug induced and alcoholic hepatitis were ruled out from his history and serological studies. The patient was eventually diagnosed as having a DMF induced toxic hepatitis and was managed with supportive care and hepatotonics. The clinical presentation and management of DMF induced toxic hepatitis were reviewed with the current literature.
Abdominal Pain ; Dimethylformamide* ; Drug-Induced Liver Injury* ; Hepatitis, Alcoholic ; Humans ; Nausea ; Vomiting

BACKGROUND AND OBJECTIVES: Alterations of olfactory function among patients with cirrhosis of the liver, acute viral hepatitis or alcoholic liver disease have been reported. The goal of this study is to evaluate the alteration of olfactory function among chronic viral hepatitis patients. MATERIALS AND METHODS: The study group consisted of 21 patients with chronic active viral hepatitis and 32 normal subjects. Between December 2006 and January 2008, olfactory function among the study groups was evaluated using the Connecticut Chemosensory Clinical Research Center and the Cross Cultural Smell Identification Test. Then, correlations between the olfactory function test scores and serological data were analyzed. RESULTS: Hepatitis patients had significantly lower smell identification test scores. Only serum total bilirubin level had negative correlation with smell identification test scores. CONCLUSION: Chronic viral hepatitis appears to influence olfactory function.
Bilirubin ; Connecticut ; Fibrosis ; Hepatitis ; Humans ; Liver ; Liver Diseases ; Liver Diseases, Alcoholic ; Smell

We experienced a case of severe alcoholic hepatitis. Combination treatment of continuous hemodiafiltration and steroid hormone was started immediately after admission. This treatment was very effective for severe alcoholic hepatitis, resulting in the shortening of the length of hospital stay. The reasons why this treatment was effective were; 1. The patient was younger, so the regeneration ability of liver cells was stronger. 2. The infection and bleeding of digestive organs except for acute renal failure were not found, resulting in the enhancement of the effectiveness for steroid hormone treatment. 3. The intensive blood purification treatment was started immediately. From this experience, we realized again that a fine collaboration of doctors, nurses and clinical engineers was very important in the intensive care of the severe diseases.
therapeutic aspects ; Steroid hormone, NOS ; Hepatitis, Alcoholic ; Combined ; Review [Publication Type]

The insulin resistance and the altered glucose metabolism in chronic liver disease increase the alteration of glucose intolerance and the prevalence of diabetes mellitus. The prevalence of DM is higher in advanced cirrhosis than in early cirrhosis and higher in C-viral hepatitis or alcoholic liver disease than in B-viral hepatitis. The purpose of this study is to assess the prevalence of DM in chronic liver disease in Korea. METHODS: We reviewed the medical records of 417 patients with chronic liver disease who visit the Yonsei University Sevrance Hospital from January 1994 to March 1998. We examined fasting blood sugar, biochemical study and abdominal ultrasonography. DM was defined on the basis of fasting hyperglycemia (fasting blood sugar exceeding 140 mg/dl) at least two consecutive samples or active treatment with insulin or oral hypoglycemic agents. RESULTS:1) The DM prevalence was 16.8%(70 cases) in total patients and 25.0% (56 cases) in cirrhotic patients. 2) According to sex, there was no statistically significant difference in DM prevalence(16.8% in men and 18.1% in women P=0.78). 3) The DM prevalence was increased with increasing of age(0% in below 30 years, 4.9% in 31-40, 19.6% in 41-50, 22.9% in 51-60, 21.3% in 61-70 and 44.4% in over 71 years, p<0.01). 3) According to severity of liver disease, the DM prevalence was higher in uncompensated cirrhosis than in compensated cirrhosis(2.3% in chronic viral carrier, 8.8% in chronic hepatitis, 17.9% in cirrhosis Child class A, 33.9% in class B, 29.5% in class C). 4) According to cause of liver disease, the DM prevalence was higher in C-viral hepatitis and alcoholics than in B-viral hepatitis(12.1% in B-viral hepatitis, 35.1% in C-viral hepatitis, 40.0% in alcoholics). CONCLUSION: The prevalence of diabetes in the patients with chronic liver disease is much higher than in general population. And the DM prevalence is increased in advanced cirrhosis and C-viral or alcoholic hepatitis. The early diagnosis and treatment of DM in chronic liver disease patients are important.
Alcoholics ; Blood Glucose ; Child ; Diabetes Mellitus* ; Early Diagnosis ; Fasting ; Female ; Fibrosis ; Glucose ; Glucose Intolerance ; Hepatitis ; Hepatitis, Alcoholic ; Hepatitis, Chronic ; Humans ; Hyperglycemia ; Hypoglycemic Agents ; Insulin ; Insulin Resistance ; Korea ; Liver Diseases* ; Liver Diseases, Alcoholic ; Liver* ; Male ; Medical Records ; Metabolism ; Prevalence* ; Ultrasonography

Hepatocellular carcinoma (HCC) is common cancer in Korea. Although HCC has been decreased recently, mortality rate is still high, especially in the 6th decades in men. While hepatitis B and C viral hepatitis is the most common cause of HCC, alcoholic hepatitis is being the major risk factor in Korea. For early detection of HCC, it is important to identify the risk group and to monitor with regular interval. Serum alpha fetoprotein and abdominal ultrasonography is mainstay for screening of HCC. Recently, new advanced techniques, including new biomarkers have been developed and introduced, but it is not certain for its usefulness as a screening method. The screening program suggested by National Cancer Center and associated society of liver disease is widely used in Korea. Based on screening programs, individual personalized surveillance program is needed for the high risk patients in practice.
alpha-Fetoproteins ; Biomarkers ; Carcinoma, Hepatocellular ; Hepatitis ; Hepatitis B ; Hepatitis, Alcoholic ; Humans ; Korea ; Liver Diseases ; Male ; Mass Screening ; Organothiophosphorus Compounds ; Risk Factors