1.Alcoholic Hepatitis.
The Korean Journal of Hepatology 2006;12(2):243-246
No abstract available.
Middle Aged
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Male
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Liver/*pathology
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Humans
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Hepatitis, Alcoholic/*pathology
2.Pathological and clinical analysis of nonalcoholic steatohepatitis.
Hong-ying PAN ; Rong-xia YE ; Jun-ping SHI ; Xiao-feng GUO
Chinese Journal of Hepatology 2003;11(6):384-384
Adolescent
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Adult
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Child
;
Diagnosis, Differential
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Fatty Liver
;
diagnosis
;
pathology
;
Female
;
Hepatitis
;
diagnosis
;
pathology
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Hepatitis, Alcoholic
;
diagnosis
;
Humans
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Male
;
Middle Aged
3.Analysis of clinical characteristics and risk factors of hepatic fibrosis in children with chronic hepatitis B combined with metabolic-related fatty liver disease.
Wwei LI ; Li Na JIANG ; Bo Kang ZHAO ; Hong Yang LIU ; Jing Min ZHAO
Chinese Journal of Hepatology 2023;31(6):601-607
Objective: To compare the clinical and pathological features of children with chronic viral hepatitis B combined with metabolic-associated fatty liver disease (CHB-MAFLD) and chronic viral hepatitis B alone (CHB alone), and to further explore the effect of MAFLD on the progression of hepatic fibrosis in CHB. Methods: 701 initially treated CHB children confirmed by liver biopsy admitted to the Fifth Medical Center of the PLA General Hospital from January 2010 to December 2021 were collected continuously. They were divided into CHB-MAFLD and CHB-alone groups according to whether they were combined with MAFLD. A retrospective case-control study was conducted. CHB-MAFLD was used as the case group, and 1:2 propensity score matching was performed with the CHB alone group according to age and gender, including 56 cases in the CHB-MAFLD group and 112 cases in the CHB alone group. The body mass index (BMI), metabolic complications, laboratory indicators, and pathological characteristics of liver tissue were compared between the two groups. The related factors affecting liver disease progression in CHB were analyzed by a binary logistic regression model. The measurement data between groups were compared using the t-test and rank sum test. The χ (2) test was used for the comparison of categorical data between groups. Results: Alanine aminotransferase (ALT, P = 0.032) and aspartate aminotransferase (AST, P = 0.003) levels were lower in the CHB-MAFLD group than those in the CHB alone group, while BMI (P < 0.001), triglyceride (TG, P < 0.001), total cholesterol (P = 0.016) and the incidence of metabolic syndrome (P < 0.001) were higher in the CHB alone group. There were no statistically significant differences in HBsAg quantification or HBV DNA load between the two groups (P > 0.05). Histologically, the proportion of significant liver fibrosis (S2-S4) was higher in the CHB-MAFLD group than that in the CHB alone group (67.9% vs. 49.1%, χ (2) = 5.311, P = 0.021). Multivariate regression results showed that BMI (OR = 1.258, 95% CI: 1.145 ~ 1.381, P = 0.001) and TG (OR = 12.334, 95% CI: 3.973 ~ 38.286, P < 0.001) were the risk factors for hepatic steatosis occurrence in children with CHB. MAFLD (OR = 4.104, 95% CI: 1.703 ~ 9.889, P = 0.002), liver inflammation (OR = 3.557, 95% CI: 1.553 ~ 8.144, P = 0.003), and γ-glutamyl transferase (OR = 1.019, 95% CI: 1.001 to 1.038, P = 0.038) were independent risk factors for significant hepatic fibrosis in children with CH. Conclusion: MAFLD occurrence is related to metabolic factors in children with CHB. Additionally, the combination of MAFLD may promote liver fibrosis progression in CHB patients.
Humans
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Child
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Hepatitis B, Chronic/pathology*
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Retrospective Studies
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Case-Control Studies
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Hepatitis B virus/genetics*
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Liver Cirrhosis/pathology*
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Non-alcoholic Fatty Liver Disease/complications*
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Risk Factors
4.Management of Intramural Esophageal Dissection with Gastric Feeding Tube in an Alcoholic-hepatitis Patient.
Ryoung Eun KO ; Won Sik JUNG ; Yoon Chae LEE ; Sung Hoon CHOI ; Seung Young SEO
The Korean Journal of Gastroenterology 2016;67(1):35-38
Intramural esophageal dissection is a rare but clinically important condition in the field of gastroenterology. Classically, intramural esophageal dissection rarely occurs in patients who are anticoagulated or have poor medical condition, and its clinical presentation may include chest pain, dysphagia and hematemesis. Herein, we present a case of intramural esophageal dissection in an alcoholic hepatitis patient that was diagnosed by endoscopy and successfully treated with conservative management.
Deglutition Disorders/diagnosis
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Enteral Nutrition
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Esophageal Diseases/*diagnosis/surgery
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Esophagoscopy
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Hepatitis, Alcoholic/*pathology
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Humans
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Intubation, Gastrointestinal
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Male
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Middle Aged
5.Drug Induced Hepatitis Mimicking Alcoholic Hepatitis.
The Korean Journal of Hepatology 2006;12(4):574-578
6.Acute-on-chronic liver failure: a new syndrome in cirrhosis.
Clinical and Molecular Hepatology 2016;22(1):1-6
Patients with cirrhosis who are hospitalized for an acute decompensation (AD) and also have organ failure(s) are at high risk of short-term death. These patients have a syndrome called Acute-on-Chronic Liver Failure (ACLF). ACLF is now considered as a new syndrome that it is distinct from "mere" AD not only because of the presence of organ failure(s) and high short-term mortality but also because of younger age, higher prevalence of alcoholic etiology of cirrhosis, higher prevalence of some precipitants (such as bacterial infections, active alcoholism), and more intense systemic inflammatory response. ACLF is a new syndrome also because severe sepsis or severe alcoholic hepatitis do not account for 100% of the observed cases; in fact, almost 50% of the cases are of "unknown" origin. In other words, severe sepsis, severe alcoholic hepatitis and ACLF of "unknown origin" are subcategories of the syndrome.
Acute-On-Chronic Liver Failure/complications/mortality/*pathology
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Age Factors
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Cytokines/metabolism
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Hepatitis, Alcoholic/complications
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Humans
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Liver Cirrhosis/*complications/diagnosis
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Sepsis/complications
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Severity of Illness Index
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Survival Rate
7.Diagnostic and Therapeutic Strategies for Severe Alcoholic Hepatitis.
The Korean Journal of Gastroenterology 2015;65(1):4-11
Alcoholic hepatitis (AH) is defined as an acute hepatic manifestation resulting from heavy alcohol intake. Histologically, alcoholic steatohepatitis (ASH) is characterized by hepatocellular steatosis, inflammation, and fibrosis. Alcohol abstinence is the sine qua non of therapy for AH and, in the milder forms, is prerequisite to clinical recovery. Severe ASH may lead to multi-organ failure such as acute kidney injury and infection, which has a major impact on survival and thus should be closely monitored. Patients with severe ASH have a drastic short-term mortality of up to 40-50%. Specific therapies should be considered for patients with severe ASH at risk of early death. Corticosteroids are the standard of care for patients with severe ASH. When corticosteroids are contraindicated, pentoxifylline may be an alternative option. Steroid responsiveness should be evaluated on the basis of Lille score. Tactically, we should explore novel therapeutic targets to suppress inflammation based on cytokine profiles, promote hepatic regeneration, limit innate immune responses, and restore altered gut mucosal integrity in severe ASH.
Adrenal Cortex Hormones/therapeutic use
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Free Radical Scavengers/therapeutic use
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Hepatitis, Alcoholic/*diagnosis/drug therapy/pathology
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Humans
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Liver Transplantation
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Pentoxifylline/therapeutic use
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Prognosis
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Severity of Illness Index
8.Model building-up and observation on the mouse carried chronic hepatitis B and nonalcoholic fatty liver disease.
Lu LU ; Yin-Lan LIU ; Wen-Jun YANG ; Jing LIU ; Yan LUO ; Zhen-Jie ZHUANG ; Jian-Yu CHEN ; Dong-Xue BIAN ; Yun-Hao XUN ; Jun-Ping SHI
Chinese Journal of Experimental and Clinical Virology 2013;27(5):332-335
OBJECTIVEEstablish the model of mouse with chronic hepatitis B virus (HBV) and nonalcoholic fatty liver disease (NAFLD).
METHODSTake 100 HBV transgenic, BALB/c mice of 4 weeks old, with each gender half. Then pick out 70 mice in one group to feed high-fat feed and the rest to feed normal feed. At the end of week 16, random kill 10 mice of high-fat, then liver tissue and serological detection target identification model is established in this paper. After that, divide the mice into model group and comparison group with 30 mice in each group. Feed model group with high-fat feed, comparison group with normal feed and normal group with normal feed till week 72 (including previous 16 weeks). Kill 10 mice of each group at the end of week 24, 48 and 72 respectively, fully automatic biochemical instrument detection of serum ALT, AST, TC, TG, FBG, fluorescence quantitative PCR method to detect HBV-DNA, chemiluminescence detection of HBsAg, liver biopsy after HE staining to evaluate histology change, observe mice model of dynamic evolution.
RESULTS(1) Feed high fat feed after 16 weeks, mice's weight, serum ALT, AST, TC, TG, FBG and blood biochemical indicators increased, HBV-DNA positive, liver HE staining obviously big blister fatty degeneration of liver cells and within the lobule lymphocytes infiltration, NAFLD activity score (NAS) getting close to NASH, the model of chronic HBV carries with NAFLD mouse built successfully. (2) The TC and TG values of model group in each period were higher than that of comparison group and normal group. (3) In week 24 and 72, HBV-DNA values of each group are obvious different from the other two groups and the difference can be applied to statistical significance (P < 0.05). (4) In week 48 and 72, NAS of each group are obvious different from the other two groups and the difference can be applied to statistical significance (P < 0.05).
CONCLUSIONS(1) Chronic HBV carries with NAFLD mice model can be established by HBV transgenic mice fed by high fat feed. (2) NAFLD accelerates the liver disease of the mice carrying HBV to some extent.
Animals ; Disease Models, Animal ; Fatty Liver ; complications ; pathology ; virology ; Female ; Hepatitis B virus ; genetics ; isolation & purification ; physiology ; Hepatitis B, Chronic ; complications ; pathology ; virology ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Non-alcoholic Fatty Liver Disease
9.The clinical characteristics of alcoholic patients with hepatitis virus infection.
Chinese Journal of Hepatology 2009;17(11):809-811
Alcohol Drinking
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adverse effects
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Hepatitis, Viral, Human
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complications
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diagnostic imaging
;
pathology
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Hepatocytes
;
pathology
;
Humans
;
Liver
;
diagnostic imaging
;
pathology
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Liver Cirrhosis, Alcoholic
;
diagnostic imaging
;
etiology
;
pathology
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Liver Diseases, Alcoholic
;
diagnostic imaging
;
etiology
;
pathology
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Liver Neoplasms
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epidemiology
;
etiology
;
pathology
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Prognosis
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Radiography
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Risk Factors
10.The roles of cyclooxygenase-2 and 5-lipoxygenase in liver disease.
Chinese Journal of Hepatology 2010;18(2):158-160
Animals
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Arachidonate 5-Lipoxygenase
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metabolism
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Cyclooxygenase 2
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metabolism
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Fatty Liver
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enzymology
;
pathology
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Hepatitis, Viral, Human
;
enzymology
;
pathology
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Humans
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Liver Diseases
;
enzymology
;
pathology
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Liver Diseases, Alcoholic
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enzymology
;
pathology
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Liver Neoplasms
;
prevention & control