1.Revision and update on clinical practice guideline for liver cirrhosis.
Ki Tae SUK ; Soon Koo BAIK ; Jung Hwan YOON ; Jae Youn CHEONG ; Yong Han PAIK ; Chang Hyeong LEE ; Young Seok KIM ; Jin Woo LEE ; Dong Joon KIM ; Sung Won CHO ; Seong Gyu HWANG ; Joo Hyun SOHN ; Moon Young KIM ; Young Bae KIM ; Jae Geun KIM ; Yong Kyun CHO ; Moon Seok CHOI ; Hyung Joon KIM ; Hyun Woong LEE ; Seung Up KIM ; Ja Kyung KIM ; Jin Young CHOI ; Dae Won JUN ; Won Young TAK ; Byung Seok LEE ; Byoung Kuk JANG ; Woo Jin CHUNG ; Hong Soo KIM ; Jae Young JANG ; Soung Won JEONG ; Sang Gyune KIM ; Oh Sang KWON ; Young Kul JUNG ; Won Hyeok CHOE ; June Sung LEE ; In Hee KIM ; Jae Jun SHIM ; Gab Jin CHEON ; Si Hyun BAE ; Yeon Seok SEO ; Dae Hee CHOI ; Se Jin JANG
The Korean Journal of Hepatology 2012;18(1):1-21
No abstract available.
Antiviral Agents/therapeutic use
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Ascites/diagnosis/prevention & control/therapy
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Cholagogues and Choleretics/therapeutic use
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Fatty Liver/diagnosis/diet therapy
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Fatty Liver, Alcoholic/diagnosis/drug therapy
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Hemorrhage/prevention & control/therapy
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Hepatic Encephalopathy/diagnosis/prevention & control/therapy
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Hepatitis B, Chronic/diagnosis/drug therapy
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Hepatitis C, Chronic/diagnosis/drug therapy
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Humans
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Liver Cirrhosis/*diagnosis/drug therapy/pathology/*therapy
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Liver Cirrhosis, Biliary/drug therapy
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Vasodilator Agents/therapeutic use
2.Diagnostic and Therapeutic Strategies for Severe Alcoholic Hepatitis.
The Korean Journal of Gastroenterology 2015;65(1):4-11
Alcoholic hepatitis (AH) is defined as an acute hepatic manifestation resulting from heavy alcohol intake. Histologically, alcoholic steatohepatitis (ASH) is characterized by hepatocellular steatosis, inflammation, and fibrosis. Alcohol abstinence is the sine qua non of therapy for AH and, in the milder forms, is prerequisite to clinical recovery. Severe ASH may lead to multi-organ failure such as acute kidney injury and infection, which has a major impact on survival and thus should be closely monitored. Patients with severe ASH have a drastic short-term mortality of up to 40-50%. Specific therapies should be considered for patients with severe ASH at risk of early death. Corticosteroids are the standard of care for patients with severe ASH. When corticosteroids are contraindicated, pentoxifylline may be an alternative option. Steroid responsiveness should be evaluated on the basis of Lille score. Tactically, we should explore novel therapeutic targets to suppress inflammation based on cytokine profiles, promote hepatic regeneration, limit innate immune responses, and restore altered gut mucosal integrity in severe ASH.
Adrenal Cortex Hormones/therapeutic use
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Free Radical Scavengers/therapeutic use
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Hepatitis, Alcoholic/*diagnosis/drug therapy/pathology
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Humans
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Liver Transplantation
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Pentoxifylline/therapeutic use
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Prognosis
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Severity of Illness Index