2.Biomarkers for hepatic sinusoidal obstruction syndrome after hematopoietic cell transplantation.
Blood Research 2015;50(3):123-125
No abstract available.
Biological Markers*
;
Cell Transplantation*
;
Hepatic Veno-Occlusive Disease*
;
Transplants*
;
Biomarkers
3.Radiation-induced liver disease: current understanding and future perspectives.
Experimental & Molecular Medicine 2017;49(7):e359-
Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer, radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation-induced toxicities in nontumorous liver tissues are associated with the development of numerous symptoms that may limit the course of therapy or have serious chronic side effects, including late fibrosis. Although the clinical characteristics of RILD patients have been relatively well described, the understanding of RILD pathogenesis has been hampered by a lack of reliable animal models for RILD. Despite efforts to develop suitable experimental animal models for RILD, current animal models rarely present hepatic veno-occlusive disease, the pathological hallmark of human RILD patients, resulting in highly variable results in RILD-related studies. Therefore, we introduce the concept and clinical characteristics of RILD and propose a feasible explanation for RILD pathogenesis. In addition, currently available animal models of RILD are reviewed, focusing on similarities with human RILD and clues to understanding the mechanisms of RILD progression. Based on these findings from RILD research, we present potential therapeutic strategies for RILD and prospects for future RILD studies. Therefore, this review helps broaden our understanding for developing effective treatment strategies for RILD.
Fibrosis
;
Hepatic Veno-Occlusive Disease
;
Humans
;
Liver Diseases*
;
Liver Neoplasms
;
Liver*
;
Models, Animal
;
Radiotherapy
4.Hepatic veno occlusive disease in a child.
Peng LIANG ; Shao PENG ; Song-Ting BAI
Chinese Journal of Contemporary Pediatrics 2010;12(4):308-309
8.Hepatic veno-occlusive disease resulting in tacrolimus toxicity after allogeneic hematopoietic stem cell transplantation.
Seung Hwan SHIN ; Seung Ah YAHNG ; Jae Ho YOON ; Sung Eun LEE ; Byung Sik CHO ; Yoo Jin KIM
Blood Research 2013;48(1):55-57
Tacrolimus is a widely used immunosuppressive agent for the prophylaxis of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). Since tacrolimus is primarily metabolized by the liver, hepatic dysfunction may affect its metabolism. Hepatic veno-occlusive disease (VOD) is an early complication of HSCT that results in hepatic dysfunction, suggesting that VOD may affect tacrolimus metabolism. We report a case of hepatic VOD accompanied by a sustained high blood trough level of tacrolimus despite its discontinuation. The findings of this case suggest that the elimination of tacrolimus can be markedly delayed in patients with hepatic VOD, and that the clinician should carefully modulate the drug dosage for these patients.
Graft vs Host Disease
;
Hematopoietic Stem Cell Transplantation
;
Hematopoietic Stem Cells
;
Hepatic Veno-Occlusive Disease
;
Humans
;
Liver
;
Tacrolimus
9.Hepatic veno-occlusive disease resulting in tacrolimus toxicity after allogeneic hematopoietic stem cell transplantation.
Seung Hwan SHIN ; Seung Ah YAHNG ; Jae Ho YOON ; Sung Eun LEE ; Byung Sik CHO ; Yoo Jin KIM
Blood Research 2013;48(1):55-57
Tacrolimus is a widely used immunosuppressive agent for the prophylaxis of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). Since tacrolimus is primarily metabolized by the liver, hepatic dysfunction may affect its metabolism. Hepatic veno-occlusive disease (VOD) is an early complication of HSCT that results in hepatic dysfunction, suggesting that VOD may affect tacrolimus metabolism. We report a case of hepatic VOD accompanied by a sustained high blood trough level of tacrolimus despite its discontinuation. The findings of this case suggest that the elimination of tacrolimus can be markedly delayed in patients with hepatic VOD, and that the clinician should carefully modulate the drug dosage for these patients.
Graft vs Host Disease
;
Hematopoietic Stem Cell Transplantation
;
Hematopoietic Stem Cells
;
Hepatic Veno-Occlusive Disease
;
Humans
;
Liver
;
Tacrolimus
10.Hepatic Veno-occlusive Disease after Bone Marrow Transplantation in Leukemic Patients: Two Cases Proven by Laparoscopic Liver Biopsy.
Bo Kyoung KIM ; Hwang CHOI ; Byung Wook KIM ; Ji Hyen CHOI ; Jae Myung PARK ; Ji Hyen JU ; Myung Gyu CHOI ; Jae Kwang KIM ; Chagn Suk KANG ; Woo Sung MIN ; Chun Choo KIM ; Kyu Won CHUNG
The Korean Journal of Hepatology 1998;4(2):179-187
The clinical syndrome of venoocclusive disease of the liver is one of several manifestations of regimen-related toxicity that can occur after high-dose cytoreductive therapy. Hepatic dysfunction after bone marrow transplantation may result from a number of causes such as pretransplant chemoradiation, graft-versus host disease, drugs for prophylaxis of graft-versus host disease, venoocclusive disease, various infections, and infiltration of recurrent malignancy. The clinical distinction of these causes may be difficult and the treatment of each cause is also quite different. Therefore the diagnosis of veno-occlusive disease is important. Veno-occlusive disease affects zone 3 of the liver acinus and produces a syndrome of jaundice, painful hepatomegaly, and fluid retention. Veno-occlusive disease occurs in up to 50% of the patients who undergo BMT and is usually associated with a high mortality rate. In Korea, there are a few case reports on venoocclusive disease after BMT which were only confirmed by clinical symptoms. This is a first report of two cases of hepatic veno-occlusive disease after allogenic BMT, which were proven by laparoscopic liver biopsy in our country.
Biopsy*
;
Bone Marrow Transplantation*
;
Bone Marrow*
;
Diagnosis
;
Hepatic Veno-Occlusive Disease*
;
Hepatomegaly
;
Humans
;
Jaundice
;
Korea
;
Leukemia
;
Liver*
;
Mortality