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Infection with hepatitis C virus (HCV) is one of the major global health problems, approximately 170 million people are infected worldwide. The chronic HCV infection is associated with a high risk of developing liver cirrhosis, hepatocellular carcinoma (HCC) and liver failure. Unfortunately, there is still no effective vaccine or antibodies available for the prevention of infection. RNA interference (RNAi) represents a promising new approach to combat viral infections, and recent developments in the field of gene therapy have increased the feasibility of clinical applications. RNAi techniques have made rapid progress in the basic understanding of HCV biology and revealed numerous new viral and host-cell factors as potential targets for therapy. Together with the improvement of gene delivery technique and the discovery of the critical role of microRNA (miRNA) in HCV infection, RNAi and miRNA-based antiviral strategies hold great promise for the future. In this article, we provide a comprehensive overview of current developments of therapeutic targets of RNAi, liver-targeted delivery systems and the potential applications of miRNAs in treatment of hepatitis C infection.
Genetic Therapy ; Hepacivirus ; genetics ; Hepatitis C ; therapy ; Humans ; MicroRNAs ; genetics ; RNA Interference

10.Molecular cloning, expression, purification and antigenicity analysis of NS3 gene of hepatitis C virus.

Zun-wen WANG ; Zi-bai QI ; Yang YU ; Jin-lian GU ; Zhen YANG ; Hua-yuan ZHANG ; He-min LI

Chinese Journal of Hepatology 2004;12(11):688-689

1.Current research progress towards understanding the roles of hepatitis c-related microRNAs.

2.Advance of the natural intergenotypic recombination in hepatitis C virus.

3.Clinical implications of heterogeneity of hepatitis C virus.

4.Investigation of the genotype distribution of hepatitis C virus among Turkish population in Turkey and various European countries.

5.Inhibitory effects of LNAzyme on expression of hepatitis C virus 5'-NCR Internal Ribosome Entry Site in HepG2.9706 cells.

6.Role of IL-28B SNPs in the treatment and prognosis of HCV infection.

7.Effects of HCV NS3 protein on apoptosis of QSG7701 cells induced by serum starvation.

8.Subgenomic replicon model of hepatitis C virus and it's application.

9.Research advances on treatment of hepatitis C infection based on RNA interference and microRNA modulation.

10.Molecular cloning, expression, purification and antigenicity analysis of NS3 gene of hepatitis C virus.

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