1.Drug-drug Interactions between Psychotropic Agents and Other Drugs in Physically Ill Patients: Experience of Consultation-liason in Korea University Hospital.
Journal of the Korean Society of Biological Psychiatry 1999;6(1):49-66
Polypharmacotherapy, both psychotropic and nonpsychotropic, is widespread in various situations including psychiatric hospitals and general hospitals. As the clinical practice of using more than one drug at a time increase, the clinical is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. The objective of this review is evaluation for drug-drug interactions often encountered in psychiatric consultation. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In psychiatric consultation, these two subdivisions of drug interactions between psychotropic drugs and other drugs are likely to happen. We gathered informations of the drugs used in physically ill patients who are consulted to psychiatric department in Korea University Hospital. And we reviewed the related literatures about the drug-drug interactions between psychotropic drugs and other drugs.
Absorption
;
Catalytic Domain
;
Drug Interactions
;
Hospitals, General
;
Hospitals, Psychiatric
;
Humans
;
Korea*
;
Metabolism
;
Plasma
;
Protein Binding
;
Psychotropic Drugs
2.A 5-year follow-up visual evoked potentials and nerve conduction study in young adults with type 1 diabetes mellitus
Heon-Seok Han ; Heon Kim ; Sang-Soo Lee
Neurology Asia 2016;21(4):367-374
Central nervous system impairment is common in diabetic patients, even in the early stages of the
disease, and could be associated with peripheral neuropathy. The aims of this study were to prospectively
investigate central nerve conduction in young adults with type 1 diabetes using pattern-reversal visual
evoked potentials (PRVEP) and to determine how those results were related to clinical risk factors and
the parameters of the peripheral nerve conduction study (NCS). A total of 36 type 1 diabetic patients
(15 males) 5-24 years of age (mean 14.5 ± 4.7) underwent PRVEP and NCS annually for five years.
For comparison, 39 healthy age and sex matched individuals (mean 14.8 ± 5.0) were evaluated as
the control group. The P100 latencies of the PRVEP were prolonged at the study entry in the patients
compared with the controls (p< 0.001). Significant correlations were not found between any of the
parameters of PRVEP and the glycosylated hemoglobin levels; however, the changes in the parameters
of the peripheral NCS were well correlated with metabolic control. The latencies and amplitudes of
the P100 were not related to the majority of the parameters of the NCS. A prolonged PRVEP latency
may be a sign of optic pathway dysfunction, which begins before apparent diabetic retinopathy. Poor
glycemic control proved to be an important risk factor over the 5 years in terms of its relation to
the development of peripheral neural pathway abnormalities. However, once central conduction was
delayed, its changes were poorly related to diabetic control and the attributes of the peripheral nerve
conduction study over the 5-year follow-up.
Diabetes Mellitus
3.Mechanisms of HPV-16-induced Transformation in Human Epithelial Cells in Culture.
Heon Soo LEE ; Jae Ho YANG ; Il Soo PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(4):298-307
Human epithelial cell line immortalized by Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 via calcium-phosphate method. Subsequently, 8 clonal cell lines were obtained after G418 selection. Among these clonal cells, clonal cell-4(C-4) and clonal cell-6(G-6) showed increases of tumorigenic cellular properties such as saturation density, soft agar colony formation and cell aggregation. Morphological alteration such as appearane of foci was observed on these two clones after passage 6 and 7(50 to 55 days after transfection). When clonal cells and control cells were treated with MNNG(0.01ug/ml), both C-4 and C-6 showed increases of tumorigenic cellular properties and the level of increase was much more elevated as compared to clonal cells prior to MNNG treatment. Appearance of foci formation was observed in C-4 and C-6 after passage-6. After passage-8, control cells and all clonal cells showed morphological alterations. It seems that treatment of cells containing HPV-16 DNA with MNNG increases tumorigenic properties of the cells and expedite morphological transformations. (continue)
Agar
;
Cell Aggregation
;
Cell Line
;
Clone Cells
;
DNA
;
Epithelial Cells*
;
Human papillomavirus 16
;
Humans*
;
Methylnitronitrosoguanidine
;
Plasmids
4.A Case of Recurrent Melanocytic Nevus.
Jong Min KIM ; Cheol Heon LEE ; Eil Soo LEE
Korean Journal of Dermatology 1989;27(1):104-107
Recurrent melanocytic nevus forms after incomplete removal of a melanocytic nevus and is chatacterized by somewhat proliferation of atypical melanocytes at the dermoepidermal junction and epidermis or recurrent junctional activity. A 73-yeat-old man had a pigmented lesion on the volar aspect of the right heel, which was excised 20 years ago. Five years thereafter, the pigmented lesion recurred in the previous operation scar and had been excised again. But pigmented lesion reappeared in the scar as an irregular patch of variegated pigmentation of browm, gray and black. Histopathologic findings showed fibrosis in the dermis and proliferation of normal and atypical rnelanocytes in the overlying epiderrnis.
Cicatrix
;
Dermis
;
Epidermis
;
Fibrosis
;
Heel
;
Melanocytes
;
Nevus, Pigmented*
;
Pigmentation
5.A Case of Allergic Contact Dermatitis to Nitrofurazone Ointment.
Kwang Soo KIM ; Jong Min KIM ; Cheol Heon LEE
Korean Journal of Dermatology 1989;27(3):296-298
Nitrofurazone is a well known sensitizer and is widely used particularly in surgical department for the treatment of secondary infection, but the reports of all ergic contact dermatitis to nitrofurazone are rare in Korean literature. We experienced a case of allergic eontact dermatitis to 0.2% nitrofurazone in 31-year-old female after dressing the grafted wound on the left index finger with the gauze embedded with 0.2% nitrofurazone olintmnt. The patch test results revealed a strong positve reaction to 0.2% nitrofurazone ointment after 48 hours.
Adult
;
Bandages
;
Coinfection
;
Dermatitis
;
Dermatitis, Allergic Contact*
;
Dermatitis, Contact
;
Female
;
Fingers
;
Humans
;
Nitrofurazone*
;
Patch Tests
;
Transplants
;
Wounds and Injuries
6.Multiple Myeloma Combined with Stomach Cancer: A case report.
Chang Heon YANG ; Myung Soo HYUN ; Hyun Woo LEE
Yeungnam University Journal of Medicine 1989;6(1):197-204
A case of multiple myeloma combined with stomach cancer and related literatures were reviewed. A 67 year-old male patient entered the hospital with dysphagia and weight loss for 3 months. Peripheral blood examination revealed anemia with rouleaux formation. Total protein of the serum was 9.9 g/dl with hyperglobulinemia (albumin 2.7 g/dl, globulin 7.2 g/dl, A/G ratio 0.375). On the electrophoresis and immunoelectrophoresis of the serum, the abnormal protein with the pattern of monoclonal gammopathy (IgG-K type) was shown. There were multiple variable sized osteolytic lesions on skull X-ray and abnormal hot uptakes of rips on bone scan and result of rib biopsy was plasmacytoma. Gastrofiberscopy was performed to search for the cause of upper gastrointestinal bleeding, revealed stomach cancer, and the result of the gastric mucosal biopsy proved to be well-differentiated adenocarcinoma.
Adenocarcinoma
;
Anemia
;
Biopsy
;
Deglutition Disorders
;
Electrophoresis
;
Hemorrhage
;
Humans
;
Immunoelectrophoresis
;
Male
;
Multiple Myeloma*
;
Paraproteinemias
;
Plasmacytoma
;
Ribs
;
Skull
;
Stomach Neoplasms*
;
Stomach*
;
Weight Loss
7.A Statistical Survey on 2205 Skin Tumors.
Kwang Soo KIM ; Kyu Joong AHN ; Cheol Heon LEE
Korean Journal of Dermatology 1990;28(6):737-746
A statistical study was done on 2205 skin tumors filed at Department of Clinical Pathology, Han Kang and Kang Nam Sacred Heart Hospital during last 10 years from 1980 to 1989. The results were summarized as follows : 1. The number of skin tumor surveyed was 2205 among total 67931 biopsy specimens, 2052 benign skin tumors, 153 malignant tumors. 2. The specimens were requested from the Department of Surgery(707 cases, 32.1 %), Dermatology(618 cases, 28.0%), Plastic Surgery(354 cases, 15.79o), and Or thopedic Surgery(223 cases, 10.1% ). 3. Among 2052 benign skin tumors, the frequently observed tumors were epidermal cyst(577 cases, 28.1%), lipoma(398 cases, 19.4%), melanocytic nevus(121 cases, 5.9 %), dermatofibroma(74 cases, 3.6%), cavernous hemangioma(72 cases, 3.5%), ea.ch of pilmatricoma and neurofibroma(63 cases, 3.1% ), granuloma pyogenicum(57 cases, 2.8%), neurilemmoma(53 cases, 2.6%), seborrheic keratosis(45 cases, 2.2%), soft fibroma(45 cases, 2.2%). 4. Among 153 malignant tumors, the frequently observed tumors were squamaus cell carcinoma(50 cases, 32.7%), basal cell carcinoma(45 cases, 29.4%), malignant melanoma(8 cases, 5.2%), Bowens disease(7 cases, 4.6%), metastatic skin tumors(7 cases, 4.6%) in order. Male to female ratio of malignant tumors was 1.6:1 and the peak age incidence was in 6th decade. 5. Male to female ratio of squamous cell carcinoma was 3.2:1 and of basal cell carcinoma 1: 1.3. The peak age incidences of both squamous cell carcinoma and basal cell carcinoma were 6th decade. The predilection sites of squmous cell carcinoma were face, neck and genitalia and those of basal cell carcinoma were face, lower extremities, neck and trunk.
Biopsy
;
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Female
;
Genitalia
;
Granuloma
;
Heart
;
Humans
;
Incidence
;
Lower Extremity
;
Male
;
Neck
;
Pathology, Clinical
;
Skin*
;
Statistics as Topic
8.I.T.P. in fullterm gravida due to chickenpox infection.
Heon Soo LEE ; Chang Kyu HUH ; Chi Dong HAN
Korean Journal of Obstetrics and Gynecology 1991;34(11):1630-1635
No abstract available.
Chickenpox*
9.Operative treatment of Weber type C ankle fracture -an evaluation of need for trans-syndesmotic screw fixation.
Eun Woo LEE ; Soo Yong KANG ; Jong Heon CHA
The Journal of the Korean Orthopaedic Association 1991;26(1):152-157
No abstract available.
Ankle Fractures*
;
Ankle*
10.Endogenous Digoxin-like Substance in Neonatal Serum, Pregnant Women and Placental Extracts.
Heon Seob SONG ; In Soo CHOI ; Dae Yeol LEE ; Jung Soo KIM
Journal of the Korean Pediatric Society 1986;29(9):12-19
No abstract available.
Female
;
Humans
;
Placental Extracts*
;
Pregnant Women*