1.Endogenous Digoxin-like Substance in Neonatal Serum, Pregnant Women and Placental Extracts.
Heon Seob SONG ; In Soo CHOI ; Dae Yeol LEE ; Jung Soo KIM
Journal of the Korean Pediatric Society 1986;29(9):12-19
No abstract available.
Female
;
Humans
;
Placental Extracts*
;
Pregnant Women*
2.Studies on the Changes of Serum Osmolality Electrolytes, Digoxin-like Substance and Plasma Renin Activity Following Angiocardiography using Hypertonic Contrast Media.
Heon Seob SONG ; Hyeong Won SHIN ; Chan Uhung JOO ; Dae Yeol LEE ; Jin Gon JUN
Journal of the Korean Pediatric Society 1987;30(4):398-405
No abstract available.
Angiocardiography*
;
Contrast Media*
;
Electrolytes*
;
Osmolar Concentration*
;
Plasma*
;
Renin*
3.Specific Immunoglobulin Responses Against Tetanus Toxoid after DPT Vaccination.
Kyung Jin SHIN ; Sng Nam CHUN ; Heon Seob SONG ; Dae Yeal LEE ; Jung Soo KIM
Journal of the Korean Pediatric Society 1987;30(6):625-632
No abstract available.
Immunoglobulins*
;
Tetanus Toxoid*
;
Tetanus*
;
Vaccination*
4.A Clinical Experience of Continuous Ambulatory Peritoneal Dialysis in Child.
Heon Seob SONG ; Byung Sook PARK ; Kyung Jin SHIN ; Beyong Sang CHOI ; Dae Yeol LEE
Journal of the Korean Pediatric Society 1987;30(5):560-568
No abstract available.
Child*
;
Humans
;
Peritoneal Dialysis, Continuous Ambulatory*
5.A Case of Williams Elfin Facies Syndrome.
Kyung Jin SHIN ; Heon Seob SONG ; Byung Sook PARK ; In Soo CHOI ; Chan Uhng JOO ; Jung Ku JO
Journal of the Korean Pediatric Society 1987;30(6):684-690
No abstract available.
Facies*
6.Current status of stem cell therapy in urology.
Korean Journal of Urology 2015;56(6):409-411
No abstract available.
Animals
;
Erectile Dysfunction/therapy
;
Humans
;
Male
;
Stem Cell Transplantation/*methods
;
Urologic Diseases/*therapy
;
Urology/methods/trends
7.Liberation of Serotonin Is Not Unaffected by Acetylcholine in Rat Hippocampus
Jae Heon KIM ; Young Soo AHN ; Yun Seob SONG
International Neurourology Journal 2021;25(Suppl 2):S114-119
Purpose:
Raised cerebral titers of acetylcholine have notable links with storage symptomatology related to lower urinary tract symptoms. The hippocampus contributes to the normal control of continence in the majority of instances (circuit 3). Owing to synaptic connections with other nerve cells, acetylcholine affects the micturition pathway via the liberation of additional cerebral neurotransmitters. Despite the fact that cerebral serotonin is a key inhibitor of reflex bladder muscle contractions, the influence of acetylcholine on its liberation is poorly delineated. The current research was conducted in order to explore the role of acetylcholine in serotonin liberation from sections of rat hippocampus in order to improve the comprehension of the relationship between cholinergic and serotonergic neurons.
Methods:
Hippocampal sections from 6 mature male Sprague-Dawley rats were equilibrated over a 30-minute period in standard incubation medium so as to facilitate [3H]5-hydroxytryptamine (5-HT) uptake. The cerebral neurotransmitter, acetylcholine, was applied to the sections. Aliquots of drained medium solution were utilized in order to quantify the radioactivity associated with [3H]5-HT liberation; any alterations in this parameter were noted.
Results:
When judged against the controls, [3H]5-HT liberation from the hippocampal sections remained unaltered following the administration of acetylcholine, implying that this agent has no inhibitory action on this process.
Conclusions
Serotonin liberation from murine hippocampal sections is unaffected by acetylcholine. It is postulated that the bladder micturition reflex responds to acetylcholine through its immediate cholinergic activity rather than by its influence on serotonin release. These pathways are a promising target for the design of de novo therapeutic agents.
8.Serotonin Discharge Regulation by Additional Neurotransmitters of Rat Hippocampus Associated With the Continence Central Circuit
Jae Heon KIM ; Young Soo AHN ; Yun Seob SONG
International Neurourology Journal 2021;25(Suppl 2):S106-113
Purpose:
The lower urinary tract is believed to be centrally regulated with the involvement of a range of neurotransmitters. The parasympathetic excitatory input to the urinary bladder is suppressed when the serotonergic system is activated, and thereby voiding is blocked. In healthy people, continence is usually underpinned by hippocampal formation (circuit 3). In order to advance knowledge of how serotoninergic neurons and additional nerve fibers were correlated, the purpose of the present work was to research how the discharge of serotonin from hippocampal slices was affected by different neurotransmitters in rat models.
Methods:
The adopted procedure involved administration of the central neurotransmitters acetylcholine, norepinephrine, dopamine, N-methyl-D-aspartate (NMDA), gamma-aminobutyric acid (GABA), glycine, and neuropeptide Y as well as monitoring of the alterations in the discharge of [3H]5-hydroxytryptamine (5-HT). Furthermore, to determine whether the effect of the neurotransmitters was influenced by interneuron, tetrodotoxin was also employed.
Results:
Acetylcholine (10-5M) did not alter [3H]5-HT discharge, whereas more 5-HT was discharged from the hippocampal slices of rats under stimulation by norepinephrine (10-5M) as well as dopamine (10-5M) and tetrodotoxin (10-6M) did not inhibit the discharge. By contrast, tetrodotoxin inhibited the discharge of [3H]5-HT that was exacerbated by NMDA (10-4M). Meanwhile, compared to control, GABA (10-5M), glycine (10-5M), or neuropeptide Y (10-6M) did not alter the [³H]5-HT discharge.
Conclusions
From the research findings, it can be concluded that 5-HT discharge from rat hippocampus is enhanced by norepinephrine and dopamine through direct effect on the 5-HT neuronal terminal. By contrast, 5-HT discharge is intensified by NMDA by activating interneurons.
9.Ectopic Prostate Tissue at the Bladder Dome Presenting as a Bladder Tumor.
Jae Heon KIM ; Yoon Mi JEEN ; Yun Seob SONG
The World Journal of Men's Health 2013;31(2):176-178
The presence of ectopic prostate tissue in the bladder is common, but the involvement of the bladder dome has rarely been reported. This case report describes a 72-year-old man who presented with gross painless hematuria. Cystoscopy revealed a smooth sessile mass at the dome region of the bladder. A complete transurethral resection of the mass was performed. Histopathological examination of the mass revealed the presence of benign ectopic prostatic tissue.
Aged
;
Choristoma
;
Cystoscopy
;
Hematuria
;
Humans
;
Prostate
;
Urinary Bladder
;
Urinary Bladder Neoplasms
10.Homogeneity Among the Korean International Prostate Symptom Score Questionnaires Used in Real Practice.
Jae Heon KIM ; Seung Whan DOO ; Won Jae YANG ; Yun Seob SONG
Korean Journal of Urology 2013;54(4):249-251
PURPOSE: We analyzed whether any problems existed in terms of the homogeneity of the Korean International Prostate Symptom Score (IPSS) questionnaire used in real practice. MATERIALS AND METHODS: Between July 2012 and August 2012, 48 Korean IPSS questionnaires used in real practice were collected. All the items on the questionnaire, including the quality of life (QoL) questions, were compared and we then determined the homogeneity of each question in comparison with the originally validated Korean version of the IPSS from 1996. RESULTS: Only 5 of 48 sources (10.4%) of the Korean IPSS totally corresponded with the original Korean version of the IPSS questionnaire. The consistency rate with the originally validated version was generally low for the answer choice items for each question, ranging from 16.6% for "less than half the time" to 35.4% for "almost always," with the exception of the item "not at all" (100.0%). The consistency rate was 60.4% for question 3 (intermittency) and 18.8% for question 6 (straining). No homogeneity was found in any of the QoL-related questions. The average consistency rate with the originally validated version was 42.2% and ranged from 22.9% for "unhappy" to the highest rate of 95.8% for "mostly satisfied." CONCLUSIONS: Compared with the originally validated Korean version of the IPSS, various Korean IPSS questionnaires used in real practice had significant problems in terms of homogeneity for both the questions and the answer choice items. Efforts are needed to ensure the uniform use of the validated Korean version of the IPSS questionnaire.
Dietary Sucrose
;
Prostate
;
Quality of Life
;
Reproducibility of Results