1.Cortical Infarction with Weakness of Individual Intrinsic Hand Muscles.
Phil Hyu LEE ; Sang Won HAN ; Ji Hoe HEO
Journal of the Korean Neurological Association 1998;16(5):697-700
With the development of electrophysiologic technique, a more detailed topographical organizations of motor cortex, especially hand area have been introduced in animal experiment. To the best our knowledge, in cerebral infarction, only one patient with isolated weakness of intrinsic hand muscles has been reported. We present two patients with cerebral infarction who showed isolated weakness in their intrinsic hand. Patient 1; A 76-year-old woman with coronary artery obstructive disease developed abrupt weakness in flexion of right thumb, index, middle finger and in adduction of thumb. Brain MRI showed a small discrete lesion in the posterior bank of left precentral gyrus. An angiography revealed an occlusion of left central sulcus artery. Prominent thumb adduction weakness was remained 11 days later. Patient 2; A 57-year-old hypertensive man was admitted because of recurrent TIA and decreased grasp power of right hand, especially flexion and adduction of thumb, index finger and middle finger. Brain MRI showed focal lamina necrosis in left precentral gyrus. An angiography revealed an occlusion of left internal carotid artery. Findings in our patients suggest that the similar arrangement of efferent zone for cortical hand area found in monkeys also may exist in human beings.
Aged
;
Angiography
;
Animal Experimentation
;
Arteries
;
Brain
;
Carotid Artery, Internal
;
Cerebral Infarction
;
Coronary Vessels
;
Female
;
Fingers
;
Hand Strength
;
Hand*
;
Haplorhini
;
Humans
;
Infarction*
;
Magnetic Resonance Imaging
;
Middle Aged
;
Motor Cortex
;
Muscles*
;
Necrosis
;
Thumb
2.The Programming of Chemotherapy Order System.
Jung Tae KIM ; Je Hwan LEE ; Hye Won HAN ; Young Seol HEO ; Yeong Man LEU ; Tae Won KIM ; Jung Shin LEE
Journal of Korean Society of Medical Informatics 1999;5(3):45-49
As a part of plan to construct a multifunctional hospital information system, We planned to develop a chemotherapy order system. First, a software developing team was established which is composed of hematooncology staffs, special pharmacists and programmer who are responsible for OCS. We set up an outline of this system after collecting various kinds of sources such as foreign examples, gathered protocol that are used for chemotherapy, and organized these protocol in programming the chemotherapy order system. This project is expected to provide accurate prescription, to shorten the time to prepare prescription, to standardize the protocol of chemotherapy within the medical center, to manage an effective dispensing schedule and to be used as a source for education and research.
Appointments and Schedules
;
Drug Therapy*
;
Education
;
Hospital Information Systems
;
Humans
;
Pharmacists
;
Prescriptions
3.The Effect of Irradiation and Epidermal Growth Factor on Cell Cycle and Apoptosis Induction in Human Epithelial Tumor Cell Lines.
Won Jeong HAN ; Min Suk HEO ; Sam Sun LEE ; Soon Chul CHOI ; Tae Won PARK
Korean Journal of Oral and Maxillofacial Radiology 2000;30(1):71-79
PURPOSE: This study was aimed to evaluate the cell cycle arrest and apoptosis induction after irradiation and epidermal growth factor(EGF) treatment in three human epithelial tumor cell lines(A431, Siha, KB). MATERIALS AND METHODS: Single irradiation of 2, 5 and 10 Gy was done on three cell lines with 5.38 Gy/min dose rate using Cs-137 irradiator at room temperature. Also, EGF of 10 ng/ml was added immediately after 10 Gy irradiation. Cell growth was evaluated by counting the living cell number using a hemocytometer at 1 day, 2 days, 3 days, 4 days and 5 days after irradiation. Cell cycle arrest and apoptosis induction were assayed with the flow cytometry at 8 hours, 12 hours, 1 day, 2 days, 3 days, 4 days and 5 days after irradiation. RESULTS: Growth of irradiated three cell lines were inhibited in proportion to radiation dose. EGF treatment after irradiation showed various results according to cell lines. On all cell lines, G2 arrest was detected after 8 hours and maximized after 12 hours or 1 day. Amount of G2 arrest was positively dose dependent. But, EGF showed no significant change on G2 arrest. G2 arrest was recovered with time at 2 Gy and 5 Gy irradiation. But, at 10 Gy irradiation, G2 arrest was continued. Apoptosis was detected at 10 Gy irradiation. On EGF treated group after irradiation, A431 and Siha cell lines showed slightly increased apoptosis but there was no statistically significant difference. KB cell line showed no marked change of apoptosis induction. CONCLUSION: Irradiation effects cell cycle arrest and apoptosis induction in three human epithelial tumor cell lines but epidermal growth factor doesn't effect change of cell cycle arrest and apoptosis induction.
Apoptosis*
;
Cell Count
;
Cell Cycle Checkpoints
;
Cell Cycle*
;
Cell Line
;
Cell Line, Tumor*
;
Epidermal Growth Factor*
;
Flow Cytometry
;
Humans*
;
KB Cells
4.The Clinical Analysis and Treatment Results of Coats' Disease in Children.
Eui Seok HAN ; Ho Kyung CHOUNG ; Jang Won HEO ; Seong Joon KIM ; Young Suk YU
Journal of the Korean Ophthalmological Society 2006;47(3):423-430
PURPOSE: To evaluate the clinical characteristics and treatment result of Coats' disease in children. METHODS: Data on demographics, clinical presentation, and ocular findings were analyzed for 67 eyes of 67 patients with Coats' disease by retrospective chart review. Among these, treatment results were analyzed from 56 eyes which had received local treatment or subretinal fluid drainage (SRFD). Treatment was considered successful when telangiectatic vessels or exudates had regressed after local treatment or when pupillary block glaucoma was treated or prevented after SRFD. RESULTS: Mean age at diagnosis was 5.0 years (5 months-15 years) and 90% were males. 67% of retinal telangiectasias were located in the temporal. There were exudative retinal detachments in 46 (69%) eyes. Among them, SRFD was performed in 19 (28%) to treat or prevent pupillary block glaucoma. The mean age at diagnosis of patients that underwent treatment was 5.1 years. In 37 of 56 patients, 95% of retinal telangiectasias were regressed after primary local treatment, and 21 eyes (31%) underwent SRFD. Management of glaucoma was achieved after SRFD in 16 patients, and one more SRFD was needed after primary SRFD in 5 patients. CONCLUSIONS: In Coats' disease, it is necessary to eradicate retinal telangiectasia with local treatment and to follow up carefully for secondary glaucoma, which can be treated with SRFD in cases of severe exudative retinal detachment.
Child*
;
Cryotherapy
;
Demography
;
Diagnosis
;
Drainage
;
Exudates and Transudates
;
Follow-Up Studies
;
Glaucoma
;
Humans
;
Male
;
Retinal Detachment
;
Retinaldehyde
;
Retrospective Studies
;
Subretinal Fluid
;
Telangiectasis
5.Is Titanium Mesh Cage Safe in Surgical Management of Pyogenic Spondylitis?.
Won HEO ; Dong Ho KANG ; Kyung Bum PARK ; Soo Hyun HWANG ; In Sung PARK ; Jong Woo HAN
Journal of Korean Neurosurgical Society 2011;50(4):357-362
OBJECTIVE: To report our experience with pyogenic spondylitis treated with anterior radical debridement and insertion of a titanium mesh cage and to demonstrate the effectiveness and safety of the use of a titanium mesh cage in the surgical management of pyogenic spondylitis. METHODS: We retrospectively analyzed the clinical characteristics of 19 patients who underwent surgical treatment in our department between January 2004 and December 2008. The average follow-up period was 11.16 months (range, 6-64 months). We evaluated risk factors, cultured organisms, lab data, clinical outcomes, and radiographic results. Surgical techniques for patients with pyogenic spondylitis were anterior radical debridement and reconstruction with titanium mesh cage insertion and screw fixation. All patients received intravenous antibiotics for at least 6 weeks postoperatively, and some patients received oral antibiotics. RESULTS: The infections resolved in all of the patients as noted by normalization of their erythrocyte sedimentation rates and C-reactive protein levels. The mean pain score on a Visual Analog Scale was 7.8 (range, 4-10) before surgery and 2.4 (range, 1-5) after surgery. The Frankel grade was improved by one grade in seven patients. After surgery, the average difference of the angle was improved about 6.96degrees in all patients. At the last follow-up, the mean loss of correction was 4.86degrees. CONCLUSION: Anterior radical debridement followed by the placement of instrumentation with a titanium mesh cage may be a safe and effective treatment for selected patients with pyogenic spondylitis. This surgical therapy does not lead to recurrent pyogenic spondylitis.
Anti-Bacterial Agents
;
Blood Sedimentation
;
C-Reactive Protein
;
Debridement
;
Follow-Up Studies
;
Humans
;
Pyridines
;
Retrospective Studies
;
Risk Factors
;
Spondylitis
;
Thiazoles
;
Titanium
6.Surgical Management of Dural Arteriovenous Fistula of The Anterior Cranial Fossa: Case Report.
Won HEO ; In Sung PARK ; Chul Hee LEE ; Jong Woo HAN
Korean Journal of Cerebrovascular Surgery 2011;13(2):70-74
OBJECTIVE: A dural arteriovenous fistula (DAVF) of the anterior cranial fossa is rare. We report a case of a DAVF of the anterior cranial fossa which was treated surgically, following endovascular treatment failure. METHODS & RESULTS: The subject was a 53-year-old male with a headache caused by a hematoma in the right frontal lobe. A vascular abnormality of the anterior cranial fossa was suspected on brain computed tomographic angiography. The subsequent transfemoral cerebral angiography revealed that the AVF of the anterior cranial fossa was mainly fed by the left anterior ethmoidal artery. Endovascular therapy using N-butyl cyanoacrylate was attempted. However, the procedure failed to occlude the fistula due to the existing feeding artery (the right anterior ethmoidal artery). Consequently, a surgical approach was undertaken and the lesion was successfully obliterated. CONCLUSION: We report a rare case of an intracerebral hematoma caused by a DAVF, which was successfully managed surgically following, endovascular treatment failure.
Angiography
;
Arteries
;
Arteriovenous Fistula
;
Brain
;
Central Nervous System Vascular Malformations
;
Cerebral Angiography
;
Cerebral Hemorrhage
;
Cranial Fossa, Anterior
;
Cyanoacrylates
;
Fistula
;
Frontal Lobe
;
Headache
;
Hematoma
;
Humans
;
Male
;
Middle Aged
;
Treatment Failure
7.The Role of Chest CT Scans in the Management of Empyema.
Jeong Suk HEO ; Oh Yong KWUN ; Jeong Ho SOHN ; Won Il CHOI ; Jae Seok HWANG ; Seung Beom HAN ; Young June JEON ; Jung Sik KIM
Tuberculosis and Respiratory Diseases 1994;41(4):397-404
BACKGROUND: To decide the optimal antibiotics and application of chest tube, examination of pleural fluid is fundamental in the management of empyema. Some criteria for drainage of pleural fluid have been recommended but some controversies have been suggested. Recently, newer radiologic methods including ultrasound and computed tomography scanning, have been applied to the diagnosis and management of pleural effusions. We undertook a retrospective analysis of 30 patients with pleural effusion who had CT scans of the chest in order to apply the criteria of Light et at retrospectively to patients with loculation and to correlate the radiologic appearance of pleural effusions with pleural fluid chemistry. METHOD: We analyzed the records of 30 out of 147 patients with pleural effusion undergoing chest CT scans. RESULTS: 1) Six of the pleural fluid cultures yielded gram negative organisms and three anaerobic bacterias and one Staphylococcus aureus and one non-hemolytic Streptococci. No organism was cultured in nineteen cases(63.0%). 2) The reasons for taking chest CT scans were to rule out malignancy or parenchymal lung disease(46.7%), Poor response to antibiotics(40.0%), hard to aspirate pleural fluid(10.0%) and to decide the site for chest tube insertion(3.3%). 3) There was no significant correlations between ATS stages and loculation but there was a tendency to Inoculate in stage III. 4) There was a significant inverse relationship between the level of pH and loculation(P<0.05) but there appeared to be no relationship between pleural fluid, LDH, glucose, protein, loculation and pleural thickening. 5) In 12 out of 30, therapeutic measures were changed according to the chest CT scan findings. CONCLUSION: We were unable to identify any correlations between the plerual fluid chemistry, ATS stages and loculations except pH, and we suggest that tube thoracotomy should be individualized according to the clinical judgement arid serial observation. All patients with empyema do not need a chest CT scan but a CT scan can provide determination of loculation, guiding and assessing therapy which should decrease morbidity and hospital stay.
Anti-Bacterial Agents
;
Bacteria, Anaerobic
;
Chemistry
;
Chest Tubes
;
Diagnosis
;
Drainage
;
Empyema*
;
Glucose
;
Humans
;
Hydrogen-Ion Concentration
;
Length of Stay
;
Lung
;
Pleural Effusion
;
Retrospective Studies
;
Staphylococcus aureus
;
Thoracotomy
;
Thorax*
;
Tomography, X-Ray Computed*
;
Ultrasonography
8.Recurrent Transient Ischemic Attacks Caused by Postprandial Hypotension in a Patient with Occlusion of Right Internal Carotid Artery.
Jinkwon KIM ; Yohan JUNG ; Sang Won HAN ; Byung In LEE ; Kyung HEO
Journal of the Korean Neurological Association 2006;24(4):356-358
We report a 72-year-old man suffering from recurrent attacks of transient drowsy mentality during meal or on orthostatic body position. Markedly disturbed collateral blood flow to right hemisphere was observed on conventional cerebral angiography. Acute and old ischemic lesions in the right internal borderzone area were also noticed on magnetic resonance image. Postprandial and orthostatic hypotension in the present case could be the cause of the recurrent neurological deficit developed in the primarily disturbed collaterals in the right middle cerebral territory.
Aged
;
Carotid Artery, Internal*
;
Cerebral Angiography
;
Humans
;
Hypotension*
;
Hypotension, Orthostatic
;
Ischemic Attack, Transient*
;
Meals
9.Acquired Immunodeficiency Syndrome Presenting with Abdominal Tuberculosis.
Byung Sung KOH ; Sang Jung KIM ; Kyoung Hwa YOO ; Kyung Han LEE ; Gi Tark NOH ; Won Seok HEO
The Ewha Medical Journal 2015;38(3):112-116
The incidence of tuberculosis (TB) had gradually been declining all over the world, but in recent years, TB has been increasing due to the spread of the human immunodeficiency virus (HIV). When immune-suppression status deteriorates further, extrapulmonary TB generally appears more often. Abdominal TB is one type of extra-pulmonary TB, which may involve the gastrointestinal tract, peritoneum, lymph nodes or solid viscera. We encountered a case who had initially been diagnosed as having abdominal TB, had progressed to acute respiratory distress syndrome and was eventually confirmed as having developed acquired immune deficiency syndrome. In cases of coinfection of TB and HIV, it is reported that immunological responses become poor and complications with higher morbidity frequently occur. Therefore, the Korean guidelines for TB should be revised to ensure whether HIV infection exists in TB patients.
Acquired Immunodeficiency Syndrome*
;
Coinfection
;
Gastrointestinal Tract
;
HIV
;
HIV Infections
;
Humans
;
Incidence
;
Lymph Nodes
;
Peritoneum
;
Respiratory Distress Syndrome, Adult
;
Tuberculosis*
;
Viscera
10.Long-term Follow-up of Patients with Diffuse Panbronchiolitis after Erythromycin Therapy.
Cheol Hyeon KIM ; Won Jung KHO ; Seung Hun JANG ; Chul Gyu YOO ; Young Whan KIM ; Dae Seog HEO ; Sung Koo HAN ; Young Soo SHIM
Korean Journal of Medicine 1997;53(3):414-419
BACKGROUND: Diffuse panbronchiolitis(DPB) is a chronic inflammatory disease affecting the respiratory bronchioles which was first described in Japan in 1966. DPB is prevalent in Japan and is known to be very rare in western countries. The first cases of DPB were reported in Korea in 1992 and the number of the patients has been increasing. The prognosis of DPR had been very poor because there had been no effective treatment for the disease. Hut it has been dramatically changed since the introduction of low-dose long-term erythromycin therapy. In Korea, there is rare experience of 1ong-term follow-up of DPH patients and we presents the results of mean 21.6 months of follow-up after erythromycin treatment. METHODS: We analyzed the long-term follow-up data of 25 DPH patients who were diagnosed in Seoul National University Hospital during the period from September 1989 to December 1994 and followed up more than 6 months with erythromycin therapy. We tried erythromycin 250mg b.i.d. on all the patients and analyzed the changes of subjective symptoms, physical signs, pulmonary function tests, and chest X-rays. RESULTS: 1) The mean follow-up period was 21.6 months. 2) Subjective symptoms improved in 96% of the patients within 3 months and 76% of the patients showed no symptom after 18 months of treatment. 3) Crackles and wheezing decreased in all patients within 3 months and completely disappeared in 76% of the patients after 18 months of treatment. 4) Diffuse small nodular lesions on chest X-ray decreased in 56% of the patients within 3 months and chest PA was normal in 32% of the patients after 12months of treatment. 5) FVC and FEV1 increased remarkably during the first 3 months and slowly increased thereafter, reaching normal level after 12 months of treatment. FEV1/FVC was 60.4% before treatment and in- creased slowly reaching 76.1% after 24 months of treatment. 6) Erythromycin therapy could be finished in 7 patients. The mean duration of medication was 26 months and no evidence of recurrence was found in 6 months of follow-up. 7) No patients had experienced the side effect of erythromycin, CONCLUSION: The prognosis of DPR is very goad when treated with erythromycin. And at least 2 years of erythromycin treatment seems to be needed for DPB patients.
Bronchioles
;
Erythromycin*
;
Follow-Up Studies*
;
Humans
;
Japan
;
Korea
;
Prognosis
;
Recurrence
;
Respiratory Function Tests
;
Respiratory Sounds
;
Seoul
;
Thorax