Objective To explore the clinical efficacy of erythromycin combined with azithromycin in the treatment of mycoplasma pneumonia in children.Methods 98 children with mycoplasma pneumonia were selected.According to the digital chart,the patients were randomly divided into the observation group and control group,with 49 cases in each group.On the basis of routine treatment,the control group was treated with azithromycin,and the observation group received erythromycin combined with azithromycin.After treatment,the disappearance time of the disease (fever,cough,pulmonary rale),hospitalization time and adverse reactions were observed in the two groups,and the clinical efficacy of the two groups was compared.Results The total effective rate in the observation group was 95.91％,which was significantly higher than that in the control group (79.5％),and the difference was statistically significant (x2 =4.721,P ＜ 0.05).Compared with the control group,the disappearance time (fever,cough,pulmonary rales) and hospitalization time of the observation group were significantly decreased (t =1.965,1.943,1.987,1.952,all P ＜ 0.01).The incidence rate of adverse reactions in the control group was 8.16％,which in the observation group was 12.24％,there was no statistically significant difference between the two groups (x2 =0.445,P ＞ 0.05).Conclusion Compared with azithromycin alone,erythromycin combined with azithromycin is effective and safe in the treatment of children with mycoplasma pneumonia.It is beneficial to shorten the course of treatment and improve the efficacy,and is worthy of further popularization and application.