1.Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia.
Hong DENG ; Xiehe LIU ; Guiqing CAI ; Henry TERWEDOW ; Zhaoxi WANG ; Xin XU
Chinese Journal of Medical Genetics 2002;19(1):6-9
OBJECTIVETo explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis.
METHODSTwenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system.
RESULTSSignificant P value (P<0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value (P<0.05) in all the subgroups divided by PANSS scale and the age of onset.
CONCLUSIONThe area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia.
Age of Onset ; Chromosomes, Human, Pair 6 ; Humans ; Linkage Disequilibrium ; Microsatellite Repeats ; genetics ; Schizophrenia ; genetics
2.A linkage disequilibrium study of methylenetetrahydrofolate reductase C677T and schizophrenia.
Hong DENG ; Xiehe LIU ; Guiqing CAI ; Xueli SUN ; Yingcheng WANG ; Henry TERWEDOW ; Zhaoxi WANG ; Xin XU
Chinese Journal of Medical Genetics 2002;19(3):198-200
OBJECTIVETo explore the relationship between the methylenetetrahy drofolate reductase (MTHFR) C677T missense mutation and schizophrenia by linkage disequilibrium study.
METHODSLinkage disequilibrium analys is was conducted bet ween MTHFR C677T and schizophrenia in 115 affected-sib-pair (105) and trios (10) families by XDT and MAPMAKER/SIBS soft system. The analyses were performed in different diagnostic categories and combined with the age of onset as well.
RESULTSNo positive results were found in the analysis in all the family in all the four diagnostic categories. Significant P values, which were P<0.05, P<0.01 respectively, were observed in the families with the affected individual's onset age less than 25 years in all the four diagnostic categories.
CONCLUSIONThe missense mutation of MTHFR C677T or other gene structure around this mutation may be one of the susceptibility gene of schizophrenia.
DNA ; genetics ; Family Health ; Female ; Gene Frequency ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) ; Mutation, Missense ; Nuclear Family ; Oxidoreductases Acting on CH-NH Group Donors ; genetics ; Schizophrenia ; genetics
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