Background/Objective: Coronary Artery Disease (CAD) is the leading cause of mortality among patients with type 2 diabetes mellitus. Several studies evaluated glycemic control and MPS resultswith good correlation. In the Philippines, data concerning this matter are few, hence this study. Methodology: This is a cross-sectional study of selected Filipino patients with type 2 diabetes mellitus without previous cardiac events who underwent stress or pharmacologic stress MPS (TI-201 or Tc-99m sestamibi) over an 18-month period at the Philippine Heart Center. Electrocardiogram and 2D echocardiogram results were also noted. Patients were grouped into adequate glycemic control (HbA1c<7.0%) and inadequate glycemic control (HbA1c >7.0%). Binary logistic regression was computed to determine association of glycemic control to MPS defects. Results: A total of 206 subjects (114 HBa1C <7.0%, 92 with HbA1c ? 7.0%), were included in the study; with male predominance. Mean HbA1c values showed direct correlation; the higher the HbA1c values, the more MPS defects. Inadequate glycemic control group had significanlty higher subjects with mild and moderate to severe degree of myocardial ischemia (p<0.001). the relative risk of having a significant CAD in the inadequate glycemic control group is 4.30 times more than their counterpart (p<0.001). Factoring the duration of inadequate glycemic control to > 10 years, relative risk increased to 7.63 Conclusion The study shows that patients with type 2 diabetes mellitus with inadequate glycemic control have increased MPS defects and highter relative risk for having significant CAD. Diabetic patients with inadequate glycemic control for > 10 years have an even higher risk of having significant CAD.
Myocardial Perfusion Imaging ; Coronary Artery Disease ; Diabetes Mellitus, Type 2 ; Glycated Hemoglobin ; Diabetes Complications