Pancreatic cancer is one of the malignant tumor with a high case fatality rate.Because the disease onset symptoms is not obvious,and the disease develops quickly, the malignant degree is high, so it is difficult to do early diagnosis in clinical, leading to poor treatment effect.In recent years, more and more of the discovery and application of pancreatic tumor markers provide a new way for early diagnosis of pancreatic cancer.This article is a review of the current status of the research on the tumor markers associated with the early diagnosis of pancreatic cancer.

Objective Resarech on the correlation between serum tumor markers CA19-9,CEA,CAS0 and the early diagnosis and staging of pancreatic cancer.Methods To compare the serum levels of the CA19-9,CEA,CA50 in 51 patients with pancreatic cancer,10 benign tumor patients and 12 chronic pancreatitis patients admitted to the Department of general surgery,Anhui Provincial Hospital from January 2013 to October 2015.Results CA19-9 expression in different stages of pancreatic cancer and other pancreatic diseases were statistically significant (P ＜ 0.05).The difference of CEA and CA50 expression in pancreatic cancer and other pancreatic diseases was statistically significant (P＜0.05).But the CEA in stage Ⅰ and stage Ⅱ,stage Ⅰ and stage Ⅲ,stage Ⅱ and stage Ⅲ patients with clear expression of the difference was not statistically significant (P ＞ 0.05).The was no significant difference in the expression of CA50 in pancreatic cancer stage Ⅰ and stage Ⅱ,Ⅲ and Ⅳ (P ＞ 0.05).The positive rate of CA19-9 in the diagnosis of pancreatic cancer was higher than that of CEA and CA50.The positive rate of CA19-9,CEA,CAS0 and were the highest in the diagnosis of pancreatic cancer.Conclusions The expression levels of CA19-9,CEA and CA50 in serum have a certain relevance to the early diagnosis of pancreatic cancer,and the value of CA19-9 is the highest in the stage of pancreatic cancer.