1.Tendon allograft transplantation repairs Achilles tendon rupture
Hengtao TANG ; Chuangjian WANG ; Xu YAN
Chinese Journal of Tissue Engineering Research 2013;(31):5626-5632
BACKGROUND:For the treatment of Achil es tendon rupture, peripheral ankle autologous tendon displacement is the traditional method in clinic, while the source of autologous tendon is limited, has damage to the donor site and has to pay with the normal power and stable structure. Al ogenic tendon has the advantages of rich sources, easy to obtain, no damage to the normal structure of the host, and can maintain its original biological structure. OBJECTIVE:To evaluate the clinical effect of tendon al ograft transplantation on the repair of Achil es tendon rupture. METHODS:Thirty cases of acute and old Achil es tendon rupture and four cases of chronic rupture with 2-5 cm deficiency were treated from August 2008 to June 2011. The cases were treated with tendon al ograft transplantation, and short leg cast was used to fix the limb after transplantation. Functional exercises were commenced at 4 weeks after cast removal. The clinical treatment results were evaluated by Arner-lindholm criteria. RESULTS AND CONCLUSION:The mean hospital stay was about 12.5 days. Twenty-five cases were fol owed-up for 1-3 years after transplantation and no rupture recurred. According to Arner-lindholm criteria, excel ent was in 25 cases, good in 3 cases, fair in 2 cases, and the excel ent and good rate was 92%. Ankle joint function was recovered to the normal level. Three cases had adhesion between Achil es tendon and adjacent tissue that had impact on the ankle dorsiflexion, and there was no significance decrease in foot pedal force. Two cases had rejection that healed after symptomatic treatment. One case had less flap margin necrosis and incision infection that healed after dressing and adjacent flap coverage. Incisions of al patients were healed at discharge. The results show that tendon al ograft transplantation has satisfactory effect for reaping the Achil es tendon rupture which is a recommended treatment option. But the long-term effect needs further observation.
2.Spinal canal volume change and clinical significance of cervical minimally invasive lamionplasty with specimen simulation
Chunlin ZHANG ; Zhaofeng ZENG ; Hengtao TANG ; Xu YAN ; Chuangjian WANG
Chinese Journal of Tissue Engineering Research 2013;(26):4849-4856
10.3969/j.issn.2095-4344.2013.26.014
3.Contrasted study between thin coronal sectional anatomy of the pineal region and MRI image
Bo SUN ; Shuwei LIU ; Yuchun TANG ; Lingzhong FAN ; Xiangtao LIN ; Zhenping LI ; Hengtao QI
Acta Anatomica Sinica 2009;40(4):660-665
Objective To investigate the morphology and relationships with the adjacent structures in the pineal region on the thin sections and to provide anatomic data for imaging diagnosis and surgical treatment of diseases in this region. Methods By CT and MRI examination, one normal head specimen was selected for this study. Using the computerized freezing milling technique, the specimen was sliced from anterior to posterior. The in vivo MR images were obtained from ten normal Chinese male adult volunteers using a 3.0 T GE scanner. The base lines of the sectioning and the MR scan were perpendicular to the AC-PC line. Then primary sections were contrasted with the corresponding MR images. Results By the appearance of the pineal peduncle and the disappearance of the pineal gland, the pineal region could be divided into three parts from anterior to posterior, and the shape changed from an inverted triangle to a trapezoid and a triangle gradually. The first interspace was getting wider in the anterior and middle parts of the pineal region, while in the posterior part of the pineal region, it was getting narrower and disappeared finally. From anterior to posterior, the bilateral internal cerebral veins were always in the midline of the pineal region and descended gradually.Conclusion By the computerized freezing milling technique, the anatomic details and adjacent relationships of the pineal region could be exhibited clearly in the thin serial sections, which could help the imaging diagnosis and surgical treatments for minute diseases in this region.
4.Clinical analysis and etiology factors of pulmonary embolism in 30 children
Fengqin LIU ; Jing ZHANG ; Xing CHEN ; Ning DING ; Fangfang DAI ; Ke WANG ; Lin TANG ; Hengtao QI ; Baoting CHAO
Chinese Journal of Applied Clinical Pediatrics 2022;37(18):1386-1391
Objective:To investigate the clinical characteristics and etiology of pulmonary embolism in children, and to discuss the efficacy and safety of anticoagulation therapy.Methods:The data of 30 children with pulmonary embolism, who were treated with anticoagulation therapy in the Department of Pediatrics, Provincial Hospital Affiliated to Shandong First Medical University from January 2017 to December 2021, were analyzed retrospectively.The etiology, clinical characteristics, complications, outcomes and prognosis after anticoagulation treatment were analyzed.Results:There were 17 males and 13 females, with an average age of (8.95±2.58) years (age range: 4-13 years). The follow-up duration was 3-59 months.(1) The symptoms included cough in 30 cases (100.0%), fever in 29 cases (96.7%), shortness of breath in 27 cases (90.0%), chest pain in 15 cases (50.0%), hemoptysis in 9 cases (30.0%), bloody secretions under bronchoscopy but no hemoptysis in 4 cases (13.3%), and respiratory failure in 2 cases (6.7%). (2) The protopathy was Mycoplasma pneumoniae infection in 23 cases (76.7%), whose symptoms accorded with refractory Mycoplasma pneumoniae pneumonia.About 16 cases (53.3%) were positive for Mycoplasma pneumoniae drug resistance mutation 2063A>G or 2064A>G.Two cases (6.7%) had nephrotic syndrome.One case (3.3%) had purpura nephritis (nephrotic syndrome type). One case (3.3%) was lupus nephritis (nephrotic syndrome type). One case (3.3%) was hereditary protein S deficiency.One case (3.3%) had osteomyelitis and Staphylococcus aureus sepsis.One case (3.3%) had congenital heart disease.(3) Complications included limb thrombosis in 7 cases (23.3%), atrial thrombosis in 2 cases (6.7%), thoracic and abdominal deep venous thrombosis in 2 case (6.7%), cerebral infarction in 2 cases (6.7%), and splenic infarction in 1 case (3.3%). (4) Imaging examination showed that 30 children had lung consolidation/atelectasis (100.0%), and 24 cases had pleural effusion (80.0%). (5) Coagulation function examination suggested D-dimer increased to ≥ 5 mg/L in 21 cases (70.0%). (6) One case (3.3%) was given thrombolytic therapy with urokinase at the acute stage.Nine cases (30.0%) were treated with heparin/low molecular weight heparin.Twenty-one cases (70.0%) first received anticoagulation therapy with heparin/low molecular weight heparin and later took oral anticoagulant.Four cases (13.3%) were treated with Warfarin and 17 cases (56.7%) with Rivaroxaban.The anticoagulant treatment lasted 1-9 months.No recurrence of embolism or sequelae of chronic thromboembolic pulmonary hypertension was observed. Conclusions:Infection, especially Mycoplasma pneumoniae infection, is the main cause of pulmonary embolism in children.The symptoms of pulmonary embolism in children are atypical, so it is difficult to distinguish this disease from primary underlying diseases.Bronchoscopy can help find occult pulmonary hemorrhage.Unexplained shortness of breath in children of any age suggests the possibility of pulmonary embolism.Combination of clinical symptoms and necessary examination contribute to early diagnosis of pulmonary embolism.Then selection of appropriate anticoagulant drugs and timely anticoagulant therapy can improve the prognosis of children.
5.Clinical characteristics and risk factors of acute myocardial infarction in elderly patients with hyperuricemia in Suzhou
Hengtao LI ; Guanghua ZHENG ; Geng LI ; Weibing TANG
Journal of Public Health and Preventive Medicine 2023;34(5):91-94
Objective To analyze the clinical characteristics and risk factors of ( acute myocardial infarction , AMI ) in elderly patients with ( hyperuricemia , HUA) in Suzhou, and to provide a theoretical basis for the prevention and treatment of AMI in patients with HUA. Methods Among of 356 patients with hyperuricemia aged ≥60 years who were admitted to Suzhou Jiulong Hospital from January 2016 to December 2021 were selected. The patients were divided into control group and AMI group according to whether they were complicated with AMI. The clinical data of the patients were collected from the medical record system, and the types of AMI and the lesions of the three main coronary vessels in patients with HUA were statistically analyzed. The serum BNP level and LVEF value of the two groups were compared. Univariate analysis and logistic regression analysis were conducted to analyze the risk factors of AMI in patients with HUA. Results Fifty-five cases (15.45%) of 356 patients with HUA developed AMI, including 31 males and 24 females. There were 26 patients (47.27%) with NSTEMI and 29 patients (52.73%) with STEMI. In addition, 30 cases (54.55%) had three-vessel lesions. Compared with the control group, the male ratio, average age, smoking history ratio, systolic blood pressure, FPG, LDL-C and Hcy levels in the AMI group were significantly increased (P<0.05), while LVEF values decreased (P<0.05). Smoking history (OR=2.987), high LDL-C (OR=3.439), high Hcy (OR=2.672) and high FPG (OR=3.874) were risk factors for AMI in patients with HUA (P<0.05). Conclusion HUA patients in Suzhou area have a high risk of AMI, and most of them are STEMI patients, with the characteristics of multi vessel branch lesions. For HUA patients with smoking history, poor control of Hcy, LDL-C and FPG, the risk of AMI is higher. Smoking cessation and control of LDL-C, Hcy and FPG levels should be actively adopted to reduce the risk of AMI.