Objective To study the clinical characteristics and prognosis of cerebral infarction combined with metabolic syndrome.Methods From July 1,2015 to March 31,2017,250 patients with cerebral infarction combined with metabolic syndrome in four comprehensive hospital in Zhongshan city were studied.The blood pressure,blood lipid,blood sugar,waist circumference,neurological deficit and disability were analyzed before and after treatment. Meanwhile,the neurological function and disability degree of blood pressure,blood lipid,blood sugar,waist circumfer-ence and non qualified patients were compared.Results After treatment for two weeks,three months and six months, the systolic blood pressure [(132.21±11.25)mmHg,(126.37 ±10.26)mmHg,(122.29 ±11.12)mmHg], diastolic blood pressure [(90.12 ±5.21)mmHg,(84.16 ±4.11)mmHg,(82.23 ±3.10)mmHg],triglycerides [(1.81±0.24)mmol/L,(1.64 ±0.35)mmol/L,(1.51±0.25)mmol/L],high －density lipoprotein cholesterol [(1.01±0.31)mmol/L,(1.08 ±0.36 )mmol/L,(1.19 ±0.34 )mmol/L],fasting plasma glucose [(6.26 ± 0.56)mmol/L,(6.10 ±0.34)mmol/L,(5.59 ±0.34)mmol/L],two－hour postprandial blood glucose [(8.36 ± 1.12)mmol/L,(7.34 ±1.10)mmol/L,(7.05 ±0.26)mmol/L],neurological deficit scores [(31.26 ±1.16)points, (26.58 ±1.05)points,(21.10 ±0.34)points],disability scores [(3.26 ±0.34)points,(2.10 ±0.25)points, (0.59 ±0.20)points]were better than those before treatment (F＝5.10,5.23,5.45,4.89,4.21,4.20,4.26,4.58, P＝0.02,0.04,0.02,0.03,0.01,0.02,0.02,0.03).After treatment for three months and six months,the waist circ-umference [(82.21±5.10)cm,(81.23 ±4.16)cm]were less than before treatment (F＝5.26,P＝0.03).After treatment,the compliance rate of blood pressure,blood lipids,blood glucose,waist circumference was 79.20%,and the not met rate was 20.80%.The neurological deficit score [(17.25 ±1.26)points]and disability score[(0.34 ± 0.12)points]were lower than those who did not meet standard(t＝29.64,17.44,P＝0.01,0.01).Conclusion High blood pressure,high blood lipid and high blood sugar are the main clinical characteristics of patients with cerebral infarction combined with metabolic syndrome,and relieving the symptoms of＂three high＂can improve the prognosis.

Infectious bone defect is bone defect with infection or as a result of treatment of bone infection. It requires surgical intervention, and the treatment processes are complex and long, which include bone infection control,bone defect repair and even complex soft tissue reconstructions in some cases. Failure to achieve the goals in any step may lead to the failure of the overall treatment. Therefore, infectious bone defect has been a worldwide challenge in the field of orthopedics. Conventionally, sequestrectomy, bone grafting, bone transport, and systemic/local antibiotic treatment are standard therapies. Radical debridement remains one of the cornerstones for the management of bone infection. However, the scale of debridement and the timing and method of bone defect reconstruction remain controversial. With the clinical application of induced membrane technique, effective infection control and rapid bone reconstruction have been achieved in the management of infectious bone defect. The induced membrane technique has attracted more interests and attention, but the lack of understanding the basic principles of infection control and technical details may hamper the clinical outcomes of induced membrane technique and complications can possibly occur. Therefore, the Chinese Orthopedic Association organized domestic orthopedic experts to formulate An evidence-based clinical guideline for the treatment of infectious bone defect with induced membrane technique ( version 2023) according to the evidence-based method and put forward recommendations on infectious bone defect from the aspects of precise diagnosis, preoperative evaluation, operation procedure, postoperative management and rehabilitation, so as to provide useful references for the treatment of infectious bone defect with induced membrane technique.