In bleeding events caused by various reasons, coagulation dysfunction due to massive consumption or loss of coagulation factors is often life-threatening. In recent years, medical evidence of using human fibrinogen concentrate to prevent or treat bleeding has emerged, providing more options for clinical treatment of bleeding. In this paper, the stability, pharmacokinetics and safety of human fibrinogen, as well as the latest advances in its clinical application in obstetrics, cardiac surgery and traumatic massive hemorrhage were summarized, and new reasonable suggestions for clinical application of human fibrinogen were also put forward.

Objective To explore the relationship between waist-hip ratio （WHR） and the risk of acute ischemic stroke （AIS） in elderly population and its clinical significance.Methods Demographic information，disease diagnosis and blood biochemical data of 8375 residents who were followed up in Huamu Community in 2019 were retrospectively analyzed. Patients were divided into AIS group（506 cases）and non AIS group（7869 cases）according to whether residents had newly developed AIS during the follow up period. The data between the two groups were compared to analyze the correlation between WHR and AIS. Multivariate binary Logistic regression was used to analyze the influence of WHR on the risk of AIS.Results In this study，the percentages of residents in the AIS group and non-AIS group were 6.04% （506/8375） and 93.96%（7869/8375） respectively. Mean WHR of residents in the AIS group and non-AIS group was（0.91±0.07）and （0.90±0.07）respectively，and the difference between the two groups was statistically significant（t=2.715，P=0.007）.There were statistical differences in age，BMI，waist circumference，WHR，meat diet，hypertension，diabetes，coronary heart disease，serum creatinine，low density lipoprotein and total cholesterol between 2 groups（P<0.05）.There were no significant differences in gender，systolic blood pressure，diastolic blood pressure，hip circumference，smoking history，drinking history，atrial fibrillation，platelets，hemoglobin，serum glutamic pyruvic transaminase，blood urea nitrogen，fasting blood glucose，high density lipoprotein and triglyceride between the two groups （P>0.05）.The correlation between WHR and AIS risk［OR（95%CI）P］was 5.07（1.31，19.57） 0.018 before，and 4.34 （1.08，17.39）0.038 after adjusting for confounding factors.Conclusions Elevated WHR increases the risk of AIS in elderly population.These findings have certain significance for advocating weight control and prevention of cerebrovascular diseases in elderly population.

Recent studies have found that immune factors exist in the pathogenesis of various sleep disorders, and sleep disorders can occur before onset of neurological autoimmune syndrome or accompany in the disease progression and recovery. Video-polysomnography can provide digital and objective information on various sleep disorders, which is helpful for in-depth clinical research on neurological autoimmune related sleep disorders. This article reviews the recent advance in video-polysomnography features of various neurological autoimmune related sleep disorders, aiming to provide reference and guidance for clinical diagnosis and evaluation.