Objective To investigate the clinical effect of anterior cervical decompression and titanium mesh with locking plate fixation in the treatment of cervical spondylosis.Methods From January 2015 to January 2016,58 patients with cervical spondylosis in Zhoushan Hospital of Traditional Chinese Medicine were selected and randomly divided into two groups,with 29 cases in each group.The control group received the anterior cervical decompression and autogenous iliac bone graft with locking plate fixation.The observation group received anterior cervical decompression and titanium mesh with locking plate fixation.The operation time,bleeding volume and postoperative complications were recorded in the two groups.The patients were followed up for 1 year after operation,the recovery of neurological function was evaluated by,JOA standard,and the bone graft fusion rate was compared between the two groups.Results The operation time,blood loss of the observation group were (80.12 ±5.13)min,(61.45 ± 3.75) mL,respectively,which were significantly less than those of the control group,the differences were statistically significant (t =2.956,2.254,all P ＜ 0.05).The incidence rate of postoperative complications in the observation group was 6.90％,which was significantly lower than 24.14％ in the control group,the difference was statistically significant(x2 =8.540,P ＜ 0.05).The postoperative JOA score of the observation group was (88.95 ± 10.41)points,which was significantly higher than (82.11 ± 7.03)points of the control group,the difference was statistically significant (t =2.192,P ＜0.05).After 1 year follow-up,the fusion rate of the observation group was 96.55％ (28/29),which of the control group was 93.10％ (27/29),the difference was not statistically significant (x2 =2.862,P =0.090).Conclusion Anterior cervical decompression and titanium mesh with locking plate fixation in the treatment of cervical spine injury has good curative effect,and has the advantages of small trauna and high bone fusion rate.