No abstract available.
Lung Neoplasms* ; Lung*

BACKGROUND: Fibronectins(FN) are large, dimeric glycoproteins present in the plasma, loose connective tissues, and some basal lamina in vivo and synthesized by a number of cells in vitro, including lung fibroblasts, and alveolar macrophages. FN can affect the migration, proliferation, differention, and even apoptosis of various cell types, all considered necessary for organogenesis. This study was undertaken to detect the changes of localization and activity of FN, a glycoprotein molecule, in stages of lung differentiation in rats. MATERIAL AND METHOD: The experimental animals(Sprague-Dawley strain) were divided into 8 groups, a control group(adult male rats), and experimental groups of 17th day fetus, 20th day fetus, first day newborn, second day newborn, 3rd day newborn, 5th day new born, 7th day newborn. We used the immunohistological stain method with gold particle to obtain the data for distribution of FN in the alveoli, blood vessels, terminal bronchioles, alveolar macrophages and type II pneumocytes. This study revealed the FN reactions at the light and electron microscopic levels. RESULT: At 17th day fetal stage, FN reactions in fetal lung were strong on the blood vessels and moderate on the stroma. At 20th day fetal stage, FN reactions were strong on the blood vessels. After birth, FN reactions in alveolar basement membrane were maximum in the 5th and 7th day newborns. FN reactions in the blood vessels were observed to be moderate in first and second day newborns, but decreased in third day newborns. FN reactions in alveolar macrophages increased after birth. FN reactions in terminal bronchioles gradually increased after birth. 6. In type II pneumocytes, FN reactions were observed to be moderate in 1st and 3rd day newborns. CONCLUSION: Immunohistochemical analysis of rat lungs at various developmental stages revealed increased deposition of FN during the pseudoglandular stage of lung development, coinciding with the period of branching morphogenesis. Also, FN is released from type II pneumocytes. This observation, together with the strategic location of FN, suggests a role in airway formation.
Animals ; Apoptosis ; Basement Membrane ; Blood Vessels ; Bronchioles ; Connective Tissue ; Fetus ; Fibroblasts ; Fibronectins* ; Glycoproteins ; Humans ; Infant, Newborn ; Lung* ; Macrophages, Alveolar ; Male ; Morphogenesis ; Organogenesis ; Parturition ; Plasma ; Pneumocytes ; Rats*

No abstract available.
Bronchiectasis* ; Bronchography*

Since sclerosing hemangioma of the lung was first described by Liebow and Hubbell in 1956, there have been several reports on cases occurring as a solitary nodule; however, sclerosing hemangiomas occurring as multiple nodules are extremely rare. The histogenesis of this tumor remains controversial and there are several hypotheses of the etiology. Three separate nodules were found in a 57-year-old housewife, one found in the right middle lobe, one in the apicoposterior segment of the left upper lobe, and one in the superior segment of the left lower lobe. The only symptom or sign presented was a dry cough. Apicoposterior segmentectomy of the left upper lobe and wedge resection of the superior segment of the left lower lobe were performed. The postoperative course was uneventful and the patient was discharged on the postoperative 15th day.
Cough ; Hemangioma ; Histiocytoma, Benign Fibrous* ; Humans ; Lung Neoplasms ; Lung* ; Mastectomy, Segmental ; Middle Aged ; Pulmonary Sclerosing Hemangioma

No abstract available.

No abstract available.

No abstract available.
Thorax*

BACKGROUND: This retrospective study tries to identify specific risk factors that may increase complication rates after the surgical treatment of tuberculous destroyed lung. MATERIAL AND METHOD: A retrospective study was performed on forty-seven patients, who received surgical treatment for tuberculous destroyed lung in the Department of Thoracic and Cardiovascular Surgery at Hanyang University Hospital from 1988 to 1998, to identify specific preoperative risk factors related to postoperative complications. Fisher's exact test was used to identify the correlations between the complications and right pneumonectomy, preoperative FEV1, predicted postoperative FEV1, massive hemoptysis, postoperative persistent empyema. RESULT: Hospital mortality and morbidity rates of the patients who received surgical treatment for tuberculous destroyed lung were 6.4% and 29.7%, respectively. In view of the hospital mortality and morbidity rates as a whole, predicted postoperative FEV1 less than 0.8L(p<0.005), preoperative FEV1 less than 1.8L(p=0.01), massive hemoptysis(p<0.005), postoperative persistent positive sputum cultures(p<0.0005), and the presence of multi drug resistant tuberculosis(p<0.05) presented statistically significant correlations. Among the postoperative complications, bronchopleural fistula, the most common complication, was found to have statistically significant corrleations with the preoperative empyema(p<0.05) and postoperative persistent positive sputum cultures(p<0.05). CONCLUSIONS: Although mortality and morbidity rates after surgical treatment of tuberculous destroyed lung were relatively low, when predicted postoperative FEV1 was less than 0.8L, when preoperative FEV1 was less than 1.8L, when massive hemoptysis was present, when postoperative sputum cultures were persistently positive, and when multi drug resistant tuberculosis was present, the rates were significantly higher.
Empyema ; Fistula ; Hemoptysis ; Hospital Mortality ; Humans ; Lung* ; Mortality* ; Pneumonectomy ; Postoperative Complications ; Retrospective Studies ; Risk Factors* ; Sputum ; Tuberculosis ; Tuberculosis, Pulmonary

No abstract available.
Thoracic Outlet Syndrome*

No abstract available.