Korean hemorrhagic fever is an acute febrile illness which causes hemorrhagic nerrosis of multiple internal organs. Some orular symptoms are described by physicians without ophthalmic examination. The authors evaluated early ocular manifestations in 21 patients (42 eyes) with Korean hemorrhagic fever, who were admitted from Oct. to Nov. in 1984. The results are summarized as follows: 1. In eleven patients (22 eyes, 52.4%), visual disturbances caused by transitory myopia were observed. 2. During the period of transitory myopic change, the intraocular pressure in the group of refrartive change was significantly raised compared to that in the group of non-refrartive change. 3. In the group of refractive change, increasing intraocular pressure and a shallowing of the anterior chamber were observed accompanied by transitory myopic change. 4. During the earIy phase of the illness, lid edema, chemosis, conjunctival injection, subconjunctival hemorrhage, and macular edema were observed.
Eye Diseases/etiology ; Eyelid Diseases/etiology ; Hemorrhagic Fever with Renal Syndrome/*complications ; Humans ; *Intraocular Pressure ; Myopia/*etiology

Adult ; Heart Diseases ; etiology ; Hemorrhagic Fever with Renal Syndrome ; complications ; Humans ; Male

Hantaviruses cause two forms of human disease: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome. Hantavirus infection can occur in pregnant women and it can have an influence on the maternal and fetal outcomes, although this is a rare finding even in endemic areas. We describe here a recent case of HFRS complicating pregnancy.
Pregnancy Complications, Infectious/*diagnosis ; Pregnancy ; Humans ; Hemorrhagic Fever with Renal Syndrome/*diagnosis ; Female ; Adult

Adolescent ; Child ; Child, Preschool ; Electrocardiography ; Female ; Fever ; complications ; Hemorrhagic Fever with Renal Syndrome ; blood ; complications ; pathology ; Humans ; Hypergammaglobulinemia ; blood ; Immunoglobulin M ; blood ; Male ; Pain ; complications

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease characterized by fever, hemorrhage and renal failure. Among the various hemorrhagic complications of HFRS, spontaneous rupture of the kidney and perirenal hematoma are very rare findings. We report here on a case of HFRS complicated by massive perirenal hematoma, and this was treated with transcatheter arterial embolization.
*Embolization, Therapeutic ; Hematoma/radiography/*therapy/virology ; Hemorrhagic Fever with Renal Syndrome/*complications ; Humans ; Kidney Diseases/radiography/*therapy/virology ; Male ; Middle Aged ; *Renal Artery/radiography

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease characterized by fever, hemorrhage, and renal failure. Among the various hemorrhagic complications of HFRS, the spontaneous rupture of an arteriovenous malformation of the testicular vessels with a retroperitoneal hematoma is a rare finding. Here, we report a case of HFRS complicated by a massive retroperitoneal hematoma that was treated with transcatheter arterial embolization.
Adult ; Arteriovenous Malformations/*complications ; Embolization, Therapeutic ; Hematoma/diagnosis/*etiology/therapy ; Hemorrhagic Fever with Renal Syndrome/*complications ; Humans ; Kidney Cortex/blood supply ; Male ; Retroperitoneal Space ; Rupture, Spontaneous ; Testis/blood supply

Graves' disease (GD) is generally presented by thyrotoxicosis with hyperthyroidism, and it is an organ-specific autoimmune disease induced by thyroid-stimulating hormone receptor autoantibodies. However, among diverse etiologies, viral infections have been suggested to trigger or to be involved in the pathogenesis of GD. Hantaan virus infection causing hemorrhagic fever with renal syndrome (HFRS) is common in South Korea and its pathogenesis is suggested to be an immunologic mechanism. We have experienced a patient who was diagnosed as HFRS with thyrotoxicosis. So we herein report the case as GD combined with the hantaan virus infection.
Graves Disease/complications/*diagnosis/ultrasonography ; *Hantaan virus ; Hemorrhagic Fever with Renal Syndrome/complications/*diagnosis ; Humans ; Male ; Radiopharmaceuticals/diagnostic use ; Thyrotoxicosis/diagnosis ; Young Adult

We describe a 51-yr-old man presenting with syncope due to torsade de pointes. The torsade de pointes was refractory to conventional medical therapy, including infusion of isoproterenol, MgSO4, potassium, lidocaine, and amiodarone. His past history, physical findings, and hormone study confirmed that QT prolongation was caused by anterior hypopituitarism that developed as a sequela of hemorrhagic fever with renal syndrome. The long QT interval with deep inverted T wave was completely normalized 4 weeks after starting steroid and thyroid hormone replacement. Hormonal disorders should be considered as a cause of torsade de pointes, because this life-threatening arrhythmia can be treated by replacing the missing hormone.
Hemorrhagic Fever with Renal Syndrome/*complications/physiopathology ; Hormone Replacement Therapy ; Human ; Hypopituitarism/drug therapy/*etiology/physiopathology ; Male ; Middle Age ; Tachycardia, Ventricular ; Torsades de Pointes/drug therapy/*etiology/physiopathology

OBJECTIVETo observe the therapeutic effect of rhubarb and Sanchi Powder (RSP) in treating patients with hemorrhagic fever in nephrotic syndrome (NS) complicated with digestive tract bleeding.

METHODSSixty patients clinically diagnosed as hemorrhagic fever in NS complicated with digestive tract bleeding were randomized into 2 groups. Fine ground rhubarb (3g) and SP (2g) were given orally to the patients in the treated group 3 - 4 times daily. Dicynonum (2g) was given by intravenously dripping to the patients in the control group.

RESULTSIn the treated group, 17 patients were cured, 5 markedly effective and 6 effective, with the markedly effective rate of 70.97% and the total effective rate of 90.32%. The corresponding number in the control group was 10, 3, 6, 44.83% and 65.52%, respectively, significant difference was shown in comparison between the two groups (P < 0.05 or P < 0.01). The average hemostatic time was (2.32 +/- 0.82) h, the platelet count was (8.84 +/- 1.13) x 10(9) /L, and the platelet aggregation rate was obviously improved in the treated group, which were significantly different to those in the control group [(4.15 +/- 0.69) h, (6.22 +/- 0.89) x 10(9)/L, respectively, P<0.01).

CONCLUSIONRSP has the action of promoting vasoconstriction, shortening the bleeding time and blood arresting, it can increase the platelet count and improve the platelet aggregation.

Adult ; Aged ; Araliaceae ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gastrointestinal Hemorrhage ; drug therapy ; etiology ; Hemorrhagic Fever with Renal Syndrome ; complications ; drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy ; Rheum

OBJECTIVETo find out the status of intrauterine infection with hemorrhagic fever with renal syndrome virus (HFRSV).

METHODSThe blood of mothers and the umbilical cords were examined by using anti-HFRSV-IgG at labor of mothers infected with HFRSV. The venous blood of naturally delivered babies were examined for anti-HFRSV-Ig M, HI test was used to type the HFRSV.

RESULTSMothers blood showed positive reaction for anti-HFRSV-IgG. Twenty-three of 27 cases of the fetal death were umbilical cords blood positive two out of twelve of umbilical cord blood that the babies were born naturally after their mothers recovered showed positive for anti-HFRSV -IgG but negative for anti-HFRSV-IgM, 14 babies born naturally normally.

CONCLUSIONSHFRSV can cause intrauterine infection, and lead to fetal death, but no post natal deformity was observed in the babies born naturally.

Female ; Fetal Blood ; immunology ; Fetal Diseases ; virology ; Follow-Up Studies ; Hantaan virus ; immunology ; Hemorrhagic Fever with Renal Syndrome ; blood ; transmission ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications, Infectious ; blood ; virology