1.Cytokine storm secondary to coronavirus disease-19 pneumonia in a preterm pregnancy: A management and bioethical dilemma
Dominica Louise A. Sumera ; Zoraida R. Umipig‑Guevarra
Philippine Journal of Obstetrics and Gynecology 2022;46(2):80-84
A 27‑year‑old primigravida at 26 weeks’ age of gestation presented with difficulty of breathing, nonproductive cough, and generalized body malaise. Coronavirus disease‑19 (COVID‑19) infection was confirmed by a positive reverse transcription‑polymerase chain reaction. She was diagnosed with severe COVID‑19 pneumonia with progressive oxygen desaturation requiring intubation and intensive care unit admission. The management and bioethical dilemma involved the use of investigational therapeutic interventions for compassionate use, with unknown effects to the fetus, namely remdesivir, tocilizumab, dexamethasone, and hemoperfusion to manage the cytokine storm and prolong pregnancy or to terminate the pregnancy hoping that it might improve the deteriorating condition of the patient. A multidisciplinary approach and family conference to solve the dilemma resulted in a successful outcome.
COVID-19
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Hemoperfusion
2.Clinical profile and outcomes of Coronavirus Disease 19 (COVID-19) patients who underwent Hemoperfusion (HP) in a tertiary COVID-19 referral hospital: A descriptive study
Sheryll Anne R. Manalili ; Jan André ; S. Montemayor ; Jen Adrian S. Montemayor ; Elizabeth S. Montemayor ; Chicki Florette C. Uy
Acta Medica Philippina 2022;56(17):44-52
Introduction:
As of February 4, 2021, a total of 530,118 COVID-19 cases were recorded in the Philippines with a
fatality rate of 2.1%. Significant morbidity from COVID-19 is caused by hyperinflammation. Hemoperfusion (HP),
which adsorbs inflammatory cytokines, has been performed in the Philippine General Hospital (PGH) as an adjunct to management given to COVID-19 patients.
Objectives:
This study aimed to describe the clinical and laboratory profile, ventilatory support, therapeutic regimens, and outcomes of COVID-19 patients who underwent hemoperfusion in PGH.
Methods:
The COVID-19 patient electronic database (April to September 2020) of the Division of Nephrology was reviewed and we included patients with COVID-19 who underwent hemoperfusion. Demographic, clinical, and laboratory data as well as therapeutics and outcomes were described.
Results:
Sixty-six patients with COVID-19 underwent hemoperfusion. The majority were male (59.1%) with an
average age of 61.3 years (SD 15). Hypertension was the most common comorbidity (62.1%). Acute kidney injury
(AKI) requiring dialysis comprised 28.8% while 33.3% had diagnosed chronic kidney disease (CKD). The majority
were critical COVID-19 cases who had acute respiratory distress syndrome (ARDS) (56.1%). The mean baseline
inflammatory marker levels (Il-6, CRP, LDH, ferritin) were elevated. Post-HP inflammatory markers decreased
except for IL-6 among patients who died. Most patients were mechanically ventilated (54.5%). Steroids were the
most common medications administered (71.2%). Mortality occurred in 62.1% of the patients. The average length of hospital stay was 20.8 days (SD 19.5), duration from admission to first HP 5.9 days (SD 5.8), and 15.3 days (SD 17.4) from first HP to death or discharge.
Conclusion
Our study showed the characteristics of patients with COVID-19 who underwent HP. Majority
were hypertensive men in their early 60s with critical COVID-19 disease. The mean inflammatory markers were
elevated with a decrease in most markers post-hemoperfusion (except for IL-6 among those who died). Despite this, mortality was still high and the average length of hospital stay was long.
Hemoperfusion
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Hemadsorption
;
COVID-19
6.An investigation of a food poisoning incident caused by Amanita fuliginea.
Zhao Xin LU ; Xue LI ; Ya Ping HE ; Chong Tao FANG ; Yong Xin SONG ; Jun WANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(8):607-609
Mistakenly picking and eating poisonous mushrooms can cause acute poisoning. In August 2020, Qingdao Hospital of Traditional Chinese Medicine handled a poisonous mushroom poisoning incident, conducted epidemiological investigation on all poisoned patients, collected suspicious food, clinical manifestations, clinical test results and treatment conditions, and identified the mushrooms as Amanita fuliginea poisoning after morphological identification. In this incident, 6 people ate grey goose paste, of which 4 were sick with a incubation period of 6~12 h. The clinical manifestations were gastrointestinal symptoms such as nausea, vomiting and diarrhea, liver and kidney damage. After symptomatic support treatment, hemoperfusion or continuous hemofiltration treatment, the patients were cured and discharged. It is suggested to strengthen the popular science education on poisonous mushroom poisoning and improve the ability of identification and clinical treatment of poisonous mushrooms in grass-roots medical institutions.
Amanita
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Hemoperfusion
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Humans
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Liver
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Mushroom Poisoning/therapy*
7.Hemoperfusion and continuous hemodiafiltration in a paraquat poisoned patient.
Hwa Young KIM ; Jee Young LEE ; Jong Tae CHO ; Sung Chul YOON
Korean Journal of Medicine 2002;63(6):706-710
Extracorporeal elimination techniques have been frequently used in paraquat poisoning. But the effect of these techniques is controversial. Plasma paraquat concentration falls rapidly during first few hours after ingestion as the compound is taken by the tissues and excreted by the kidney. Tissue binding is very strong, resulting in slow release of substance from the tissues into the plasma. Thus, once the substance has reached its body stores, it is very difficult to eliminate. For these reasons, any effective extracorporeal elimination therapy should be initiated as early as possible, while paraquat concentrations are high and thereafter, continuous elimination therapy should be maintained to keep plasma paraquat levels as low as possible and remove the toxin as it enters the circulation from tissue stores. We present a case of paraquat poisoning treated by hemoperfusion and hemodiafiltration on this theoretical basis.
Eating
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Hemodiafiltration*
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Hemoperfusion*
;
Humans
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Kidney
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Paraquat*
;
Plasma
;
Poisoning
8.An in vitro blood compatibility assessment on the adsorptive resin in hemoperfusion filter cartridges.
Chinese Journal of Medical Instrumentation 2013;37(6):444-446
OBJECTIVETo investigate necessity of the further processing for adsorptive resin material.
METHODSAccording to GB/ T 16886.4, coagulation tests, haematology tests, in vitro spontaneous platelet-adhesion test and complement activation tests were conducted respectively to assess the in vitro blood compatibility of adsorptive resin material.
RESULTSIn comparison with polypropylene, he adsorptive resin material appears to be a very slight activator to the endogenous blood coagulation system, it can inhibited the exogenous blood coagulation system very significantly (P < 0.01), it can adhere to fibrinogen, red blood cells, reticulocytes very significantly (P < 0.01), and platelet significantly (P < 0.05). The adsorptive resin material is also revealed to be a very significant activator (P < 0.01) to the complement system.
CONCLUSIONSThe in vitro blood compatibility assessment witnesses that it is very necessary for the adsorptive resin material to go through the certain special processing(such as the surface modification and the microencapsulation technology, etc) before its application to human being.
Biocompatible Materials ; Hemoperfusion ; instrumentation ; Humans ; Materials Testing ; Resins, Synthetic
9.The rabbit experimental study for toxicokinetics of chlorpyrifos impacted by hemoperfusion.
Xiang GUO ; Xiao CHEN ; Hongshun ZHANG ; Xin LONG ; Qian HE ; Chengye SUN ; Xianqing HUANG ; Jian HE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2015;33(11):844-846
OBJECTIVETo investigate toxicokinetic parameters impacted by hemoperfusion after oral chlorpyrifos exposure, to investigate the adsorption effect of hemoperhusion for chlorpyrifos poisoning.
METHODS12 rabbits were divided into two groups after oral exposure with chlorpyrifos 300 mg/kg body weight. Control group: without hemoperfusion; hemoperfusion group: hemoperfusion starts 0.5 h after chlorpyrifos exposure and lasts for 2h. Blood samples were collected at different times, concentrations of chlorpyrifos were tested by GC, then, toxicokinetic parameterswere calculated and analysis by DAS3.0.
RESULTSIn hemoperfusion group, peak time was (7.19±3.74) h, peak concentrations was (1.37±0.56) mg/L, clearance rate was (13.93±10.27) L/h/kg, apparent volume of distribution was (418.18±147.15) L/kg The difference of these parameter were statistically significant compared with control group (P<0.05).
CONCLUSIONHmoperfusion will decrease the inner exposure and load dose of rabbits with chlorpyrifos poisoning.
Animals ; Chlorpyrifos ; pharmacokinetics ; toxicity ; Hemoperfusion ; Metabolic Clearance Rate ; Rabbits ; Toxicokinetics
10.Effect of Hemoperfusion on Treatment for Paraquat Poisoning.
Tae Hun LEE ; Seong Wook YANG ; Tae Kwan LEE ; Su Young CHOI ; Yong Ung LEE ; Kwang Young LEE
Korean Journal of Medicine 1997;52(1):114-119
Paraquat is a very potent herbicide which causes fatal toxicity when ingested, and there is no specific antidote against it. So it is known that most of the patients who ingested it die of pulmonary fibrosis. We used hemoperfusion(HP) for the treatment against paraquat poisoning from July 1993 till March 1994 and analysed the data using SPSS/PC ver4.0 for chi-square and t-test for mean +/- SD. The results were as follows: 1) A total of 36 paraquat poisoning patients(22 males and 14 females, mean age 48.8 years) visited our hospital, and i8 patients out of 36 received hemoperfusion(total 90 cycles); there were statistically significant differences in ages(41.4 +/- 15.6 year vs 56.2 +/- 15.0 year, p<0.05), but there was no significant difference in the amount of paraquat ingested(59.6 +/- 72.7ml vs 78.6 +/- 83.6ml, p=NS), gastric lavages(13/18 vs 16/18, p=NS), and use of Fuller's earth(8/18 vs 4/18, p=NS) between the patients who received HP and those who did not receive HP. 2) All the patients who did not receive HP died, but 9 patients out of 18 who received HP survived(p<0.005). There was no significant difference in ages(46.8 +/- 9.8 year vs 36.0 +/- 18.8 year, p=NS), amount of paraquat ingested(87.5 +/- 94.2 ml vs 34.8 +/- 36.4 ml, p=NS), gastric lavages(7/9 vs 6/9, p=NS), use of Fuller`s earth(5/9 vs 3/9, p=NS), and interval from the ingestion of paraquat to HP(52.449.9 hr vs 38339.7 hr, p=NS) between patients who died and those who survived, but SCr levels on arrival in expired patients were higher than those in surviving patients(5.0 +/- 3.5mg/dl vs 1.4 +/- 0.6mg/dl, p<0.05). Therefore, this suggests that hemoperfusion is very effective in the treatment of paraquat poisoning, and hemoperfusion is the most important factor in the prognosis of the patients.
Eating
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Female
;
Hemoperfusion*
;
Humans
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Male
;
Paraquat*
;
Poisoning*
;
Prognosis
;
Pulmonary Fibrosis