Objective To evaluate the effects of modified Fushen Powder on learning and memory of normal mice and mouse model with impaired learning and memory,so as to provide experimental evidence for treating mild cognitive impairment.Methods Adult Kunming male mice were randomly divided into normal group,model group,positive drug group (piracetam group at dose of 0.6 g/kg), high dose,middle dose and low dose of modified Fushen Powder groups (high-,mid-,low-dose group) at the dose of 5.6,11.2,and 22.4 g/kg respectively.Ethological examination using Morris water maze, locomotor activity system,step-down test and step-through test was used to study the effects of modified Fushen Powder on mice locomotor activities and disorders of memory acquisition,consolidation and retrieval due to chemical substances.And the activities of acetyl cholinesterase (AchE),superoxide dismutase (SOD)and content of malondialdehyde (MDA)in cortex were detected by chromatographic colorimetry.Results Compared with normal group,the mice in both low-dose group and mid-dose group showed significant increasing in exploratory behavior within the first 15 minutes (P <0.01 ),but no difference in the next 15 minutes;furthermore,low-dose and mid-dose Fushen Powder increased the scores of learning and memory.Compared with control group,low,middle,and high dose of Fushen Powder relieved disorder of memory acquisition(P <0.01),in addition,middle dose relieved disorder of memory retrieval (P <0.01)and decreased the activity of AchE(P <0.01 ),increased the activity of SOD (P <0.01 ),and the content of MDA (P <0.01 ).Conclusion The effects of modified Fushen Powder against the disorders of memory acquisition,consolidation and retrieval induced by scopolamine, sodium nitrite and ethanol were proved,with increasing the mice’s exploratory behavior in a novel environment and no obvious influence on their locomotive activity.The mechanism of modified Fushen Powder on antagonizing the memory disorders can be related to its effects of decreasing activity of AchE, content of MDA,and increasing activity of SOD in brain tissues.

Bio-based polyamides are environment-friendly polymers. The precursors of bio-based polyamides come from bio-based materials such as castor oil, glucose and animal oil. Bio-based polyamides precursors include bio-based amino acids, bio-based lactams, bio-based diprotic acid and bio-based diamines. In this paper, we discussed the route of the precursors of bio-based polyamides that come from bio-based materials. We discussed the properties of bio-based polyamides. Bio-based PA11and bio-based PA1010 are well-known bio-based polyamides; we discussed the origin materials of the precursors, the route of manufacturing bio-based PA11 and PA1010, and their modifications status. The variety, classification and commercial production of bio-based polyamides were described in details, as well as bio-based polyamides development in China.
Animals ; Biotechnology ; Castor Oil ; China ; Glucose ; Nylons ; chemistry ; Polymers