A clinical observation was made on the patients with Wilms' tumor admitted to the Yonsei University Hospital during the period from January, 1974 to December, 1981. 1. Age distribution was between 5 months to 76/12 years, the highest incidence rate was in the age group of 12 to 24 months. 2. Mass in abdomen was the most common symptom occurred in 63.2%, gross hematuria in 31.6%, abdominal distention and anorexia in 20.1% each and the others. 3. Left to right ratio was 1.7:1 and simultaneous bilateral tumor was not observed. 4. On I.V.P., 47.4% of cases revealed nonfunctioning kidney. Right renal deformity or displacement was observed in 42.1%, calcification in the tumor mass in 10.5%. 5. On treatment of Wilms' tumor, surgery, irradiation and chemotherapy was performed on 11 cases, surgery and post-op, chemotherapy 4 cases, surgery only 2 cases and irradiation and chemotherapy only 1 case each.
Abdomen ; Age Distribution ; Anorexia ; Congenital Abnormalities ; Drug Therapy ; Hematuria ; Humans ; Incidence ; Kidney ; Wilms Tumor*

Aspergillus species are primarily pulmonary pathogens but can involve extra-pulmonary organs by angioinvasive properties. Isolated renal aspergillosis is extremely rare even among the immunocompromised patients. Recently, we experienced a case of isolated renal aspergillosis presenting gross hematuria and renal mass-like lesion in a patient with acute myelocytic leukemia, who was treated with systemic amphotericin B and oral itraconazole after nephrectomy. To our knowledge, this is the first report of isolated renal aspergillosis in a patient with acute leukemia receiving chemotherapy. Here, we report this case with a review of literature.
Amphotericin B ; Aspergillosis* ; Aspergillus ; Drug Therapy ; Hematuria ; Humans ; Immunocompromised Host ; Itraconazole ; Leukemia ; Leukemia, Myeloid, Acute* ; Nephrectomy

A 30 years old male suffering from renal pain, hematuria and frequency of urination, was found to have horseshoe kidney with renal tuberculosis. The diagnosis was made through urinalysis, intra-venous pyelography and retrograde pyelography. This is a report of the good results gained by partial nephrectomy and antituberculous chemotherapy. It was compared with several literary reviews.
Adult ; Diagnosis ; Drug Therapy ; Hematuria ; Humans ; Kidney* ; Male ; Nephrectomy ; Tuberculosis* ; Tuberculosis, Renal ; Urinalysis ; Urination ; Urography

During 5 years, from January 1976 to December 1980, clinical observation on management of ureteral stones was made on 169 admitted patients with ureter stones. Following results were obtained. 1) Among total 1054 in-patients, 169 cases (16.0%) had ureteral stones, and male to female ratio was 2 : 1. 2) Patients with 20-40 of his age was half. 3) On seasonal distribution, it was most prevalent on Summer. 4) 113 cases were located on lower ureter, and laterality was even. 5) Most common symptoms were renal colic and hematuria (91.8%) 6) Ureterolithotomy was done in 127 cases. In 86 cases of lower ureter stones, less than 1cm in size. conservative fluid therapy and cystoscopic extraction was successful in 44 cases. 7) Post-operative complications were urinary leaking (16 cages), wound infection(12 cases), hematuria (3 cases), ureteral stricture (1 case), and pyelonephritis (1 case).
Constriction, Pathologic ; Female ; Fluid Therapy ; Hematuria ; Humans ; Male ; Pyelonephritis ; Renal Colic ; Seasons ; Ureter* ; Wounds and Injuries

Primary or metastatic malignant melanoma can mimic benign blue nevus in rare cases, making the diagnosis challenging. Herein, we report an exceptionally rare case of blue nevus-like melanoma and its blue nevus-like metastasis which was detected by catheterized urine cytology. The patient presented with blue-colored papuloplaques on his temple which were diagnosed as blue nevus-like melanoma on punch biopsies. While he was admitted for administration of chemotherapy, hematuria was detected. Catheterized urine cytology revealed singly scattered oval to spindle-shaped pigmented cells with a moderate degree of variation in shape and size. Many of them had small nuclei with indiscernible to inconspicuous nucleoli while only a few cells showed nuclear enlargement and nuclear hyperchromasia, which could be diagnostic pitfalls. Most of the cells on the smear were positive for HMB45 immunostaining, which confirmed the diagnosis of metastatic blue nevus-like melanoma. To the best of our knowledge, the present case is the first report describing cytomorphologic findings of blue nevus-like metastasis of melanoma in the urine specimen.
Biopsy ; Catheters* ; Diagnosis ; Drug Therapy ; Hematuria ; Humans ; Melanoma* ; Neoplasm Metastasis ; Nevus, Blue

Type IV collagen is a component of the extracellular matrix in the basement membrane. Abnormal secretion or assembly of type IV collagen may lead to kidney lesions resulting in numerous nephropathy symptoms, e.g., Alport syndrome, thin basement membrane nephropathy, and focal segmental glomerulosclerosis. Treatment for type IV collagen-related nephropathy includes drugs, kidney transplantation, gene and cell therapy. However, drugs are not always effective, and kidney transplantation is hindered by the shortage of donors. Moreover, basement membrane nephritis often occurs after kidney transplantation. Therefore, gene and cell therapy probably is the most promising treatment for type IV collagen related nephropathies.
Cell- and Tissue-Based Therapy ; Collagen Type IV ; Glomerulosclerosis, Focal Segmental ; Hematuria ; Humans ; Nephritis, Hereditary

OBJECTIVETo systematically evaluate the effects of finasteride on hematuria associated with benign prostatic hyperplasia (BPH).

METHODSWe electronically searched MEDLINE (December 1966-April 2009), EMBASE (December 1974-April 2009), The Cochrane Library (Issue 1, 2009), CNKI (December 1994-April 2009), VIP (December 1989-April 2009) and CBM (December 1978-April 2009) , and handsearched several relevant journals as well. Randomized controlled trials were assessed with the methods recommended by the Cochrane Collaboration. The data were screened and systematically analyzed by at least two reviewers independently using the RevMan 5.0 software.

RESULTSCompared with the placebo control group, the finasteride group showed a significantly decreased incidence of hematuria during the 12 months follow-up period (OR 0.11, 95% CI: 0.06-0.21, P < 0.05).

CONCLUSIONFinasteride has desirable therapeutic and preventive effects on BPH-associated hematuria. More well-designed multicentered randomized controlled trials of large sample size are invited to provide further evidence for this conclusion.

Finasteride ; therapeutic use ; Hematuria ; drug therapy ; etiology ; prevention & control ; Humans ; Male ; Prostatic Hyperplasia ; complications ; drug therapy ; Randomized Controlled Trials as Topic

Although, renal carcinoma represent 2 to 3% of all human cancers, the impredictable nature, and unique clinical and biological features of renal carcinoma place it among the most interesting of human malignancies. Total surgical excisions offers the only certain cure for nephrocarcinoma, but additional benefit may be achieved by utilization of adjuvantive methods including surgical excision of metastasis, radiation, chemotherapy, and immunotherapy. So, 28 patients with renal cell carcinoma were analyzed retrospectively in order to 1) determine the effectiveness of systemic chemotherapy-hormonal and non-hormonal, 2) identify the clinical features of renal cell carcinoma that may be important in prognosis and 3) characterize the paraneoplastic features of renal cell carcinoma. The classic triad of signs and symptoms including pain, hematuria, and palpable tumor mass presents in only 7%. Paraneoplastic syndrome occurred in up to 28.6% Metastasis was present at diagnosis in 25 % of the cases and developed within 1 year in an additional 10.7%. Surgery was employed to 23 patients for the purpose of complete cure of the disease or palliation and adjuvantive therapy was employed either to palliate symptoms or to attempt eradication of metastatic deposits to 9 patients with or without surgery. Most of metastatic disease was unresponsive objectively to either primary nephrectomy or to a variety of chemotherapy trial. Improving diagnostic capabilities and the introduction of more sophisticated diagnostic equipment promise to provide still earlier identification of patients with renal cell carcinoma and to allow surgical intervention at curable stages of disease.
Carcinoma, Renal Cell* ; Diagnosis ; Diagnostic Equipment ; Drug Therapy ; Hematuria ; Humans ; Immunotherapy ; Neoplasm Metastasis ; Nephrectomy ; Paraneoplastic Syndromes ; Prognosis ; Retrospective Studies

BACKGROUND: Hemorrhagic cystitis(HC), a common complication of bone marrow transplantation(BMT), is known to be associated with toxic metabolites of chemotherapy drugs or reactivation of primary virus infections. In this study, we evaluated the association between polyomaviruria and HC in BMT patients. METHODS: Urine specimens of 29 patients with HC after BMT were requested for the detection of polyomavirus by culture and polyomerase chain reaction(PCR). Several clinical parameters were analyzed in relations to the presence of polyomaviruria. For comparison, 19 patients without HC after BMT were involved in this study. RESULTS: Overall, 45 of 558 patients developed HC after BMT, and the incidence of HC was estimated to be 8.1%. Patients group showed significantly high prevalence of BK viruria compared with control group by PCR(72.4% vs 31.6%, P = 0.005). In patients group, BK virus was isolated in 44.8%(13/29) by culture and detected in 72.4%(21/29) by PCR. Results of both methods were agreed in 65.5%(19/29). JC virus was detected in 6.9%(2/29) by PCR. Sex, conditioning regimen, graft-versus-host disease(GVHD), onset time after BMT and duration of hematuria did not show any statistically significant differences between the two groups based on the presence of BK viruria by PCR. CONCLUSIONS: High prevalence of BK viruria in HC patients after BMT suggests the possible association between BK virus and HC. However, we could not find any significant clinical parameters in association with BK viruria.
BK Virus ; Bone Marrow Transplantation ; Bone Marrow* ; Cystitis* ; Drug Therapy ; Hematuria ; Humans ; Incidence ; JC Virus ; Polymerase Chain Reaction ; Polyomavirus ; Prevalence

Although it has been estimated that from 90 to 95% of all vesical neoplasms are of epithelial origin, and about 80% or more of carcinomas of the bladder are of transitional cell type, pratically all of the other constituents of the bladder have been known to give rise to benign and malignant tumors. A clinical observation was made on the non-transitional cell bladder tumors of the patients in the department of urology, Seoul National University Hospital during the period from 1966 to April, 1976. The following results were obtained: 1) During the period, 3699 patients were hospitalized, there were 293 cases of bladder tumors giving a rate of 7.9%. 2) Among 187 cases of bladder tumors there were 15 cases of non-transitional bladder tumors with a rate of 8%. 3) Age distribution was between 28 and 76 years. 4) Following symptoms could be found, hematuria in 93%, frequency 40%, dysuria 33% and other symptoms. 5) Squamous cell carcinoma was observed on 8 cases (4.3%), adenocarcinoma 3(1. 6%), metastatic carcinoma 2 (1.0%), malignant lymphoma 1 (0.5%). 6) Segmental resection was performed in 5 cases, total cystectomy 4, TUC 2 cases. Radiation and chemotherapy were combined in special cases. 7) 3 patients with squamous cell carcinoma died within 1 year after treatment.
Adenocarcinoma ; Age Distribution ; Carcinoma, Squamous Cell ; Cystectomy ; Drug Therapy ; Dysuria ; Hematuria ; Humans ; Lymphoma ; Seoul ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urology