No abstract available.
Helicobacter Infections* ; Helicobacter* ; Learning*

The study was conducted on 81 patients with age from 6 to 15 years and have recurrent abdominal pain who were treating at the HuÕ Central Hospital between July 2000 to July 2001. It was found that the H. pylori infection rate is relative high in the patients with recurrent abdominal pain (41.98%), There was not difference in the rate of infection between two genders, age groups and between rural and urban. This rate is significant high in patients with recurrent abdominal pain who have family history of this condition, time of recurrence is longer than 12 months and the frequency of pain is more than 4 episodes.
Helicobacter infections ; abdominal pain

Helicobacter pylori (H. pylori) infection can be diagnosed either by invasive techniques requiring endoscopy and biopsy (histological examination, culture, polymerase chain reaction) and or noninvasive techniques (urea breath test, serology, urine or blood, detection of H. pylori antigen in stool specimen). At present, no single test can be absolutely sufficient to detect the colonization by H. pylori, and a combination of above two tests is recommended if feasible. Because all the tests have their pitfalls and limitations, the choice of tests should depend on the clinical circumstances, the likelihood ratio of positive and negative tests, the cost-effectiveness of the testing strategy, and the availability of the tests. It is important to know which test in a certain clinical setting gives the best outcome. Some clinical circumstances warrant invasive studies, principally in patients with alarm symptoms (bleeding, weight loss, etc.) as well as older patients with new-onset dyspepsia. Endoscopy may also be advisable in patients who have failed eradication therapy and need culture to examine antimicrobial sensitivity testing to determine appropriate regimen. Recent Western studies have also demonstrated that a strategy of 'test and treat' for H. pylori in uninvestigated, young (<45 years), dyspeptic patients in primary care is safe and reduces the need for endoscopy. Therefore, it is necessary to hold a second consensus meeting for the diagnosis and treatment of H. pylori infection in Korea for the renewal of clinical guidelines in primary, secondary, and tertiary care based an evidence-based analysis.
Helicobacter Infections/*diagnosis ; *Helicobacter pylori ; Humans

Helicobacter Infections ; diagnosis ; therapy ; Helicobacter pylori ; Humans

The study involved 81 patients aged from 6 to 15 years who were treated at the HuÕ Central Hospital between July 2000 to July 2001. The results showed that H. pylori infection played an important role in gastroduodenal pathology in pediatric patients with persistent abdominal pain. Rate of patients with persistent abdominal pain who have gastric lesions is high (56.67%). 88.89% of patients who have H. pylori infection have duodenal lesions. 100% of patients who have persistent abdominal pain with duodenal ulcer have H. pylori infection.
Helicobacter Infections ; abdominal pain ; child

No abstract availble.
Animals ; *Cell Line ; *Helicobacter Infections ; *Helicobacter pylori ; Humans

Helicobacter pylori (H. pylori) causes chronic gastritis in human stomach, a minority of which progress to peptic ulcer disease, atrophic gastritis, or gastric malignancies. Clinical outcomes of H. pylori infection has been shown to depend on the variability of H. pylori virulence factors, host susceptibility, environmental factors and their interactions. This review provides an update on the molecular pathogenesis of H. pylori infection, focused on H. pylori virulence factors, H. pylori-gastric epithelium interactions, and modulation of host cell signaling. Understanding of H. pylori molecular pathogenic mechanism will facilitate the development of novel treatment strategies for eradication of the bacterium and prevention of H. pylori-induced gastropathy.
Helicobacter Infections/microbiology ; Helicobacter pylori/*pathogenicity ; Humans ; *Virulence Factors

Helicobacter pylori (H. pylori), a long term colonizer of human stomach is known to infect a half of mankind. Gastric and duodenal ulcer, gastric adenocarcinoma and MALT lymphoma develop in a subset of infected individuals. Pathogenesis of H. pylori infection is based on the long-term host to bacterial interaction and affected by the virulence factors of the bacterium, environmental and host factors (age, sex, blood type). Mucosal inflammation is the basic principle mechanism underlying the disease development in which tissue destruction may be initiated and maintained by both the bacterial toxins (CagA, VacA, LPS) and immune responses by the host. Immune evasion with bacterial modulation of host response affects the long-term host colonization. Colonization is also affected by urease and/or motility of the bacterium, presence of lipopolysaccharide (LPS) and various bacterial enzymes. Gastric mucosal atrophy and intestinal metaplasia can develop during the course of H. pylori infection predisposing to carcinogenesis. Host cytokine gene polymorphism would be the one explanation for host susceptibility to peptic ulcer or gastric cancer. Investigation into the pathogenesis of H. pylori related diseases could provide an answer to the impact of chronic host to microbial interaction resulting human diseases.
Gastrointestinal Diseases ; Helicobacter Infections/microbiology/*physiopathology ; *Helicobacter pylori/physiology ; Humans

No abstract available
Cardiovascular Diseases/*microbiology/physiopathology ; Helicobacter Infections/*complications ; *Helicobacter pylori ; Humans

Helicobacter pylori (HP) is an infectious pathogen which can easily infringe gastric mucosa. If the body is infected by HP, it can release cytokines, such as TNF-alpha, IL-1 and IL-6. These cytokines can regulate the absorption and transformation of bone, promote the formation of osteoclast, and then cause localized or systemic osteoporosis. HP infection may decrease the level of estrogen and vitamin B12, which is considered as a risk factor for osteoporosis. Helicobacter pylori infection is related with the occurrence of gastritis, peptic ulcer and gastric malignancies, and these diseases and treatments are associated with osteoporosis. Meanwhile the application of proton pump inhibitor (PPI) can influence absorption of calcium, decrease the level of serum calcium and increase the risk of fracture. Gastrostomy may cause bone metabolism disorders.
Helicobacter Infections ; complications ; drug therapy ; Helicobacter pylori ; Humans ; Osteoporosis ; etiology