1.Textual Research of Pediatric Famous Classical Formula Daochisan Based on Ancient and Modern Literature
Lyuyuan LIANG ; Hejia WAN ; Jinyan ZHANG ; Keke LIU ; Jialei CAO ; Xianghan TAN ; Bingqi WEI ; Bingxiang MA ; Yajing HE
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(11):218-227
Daochisan is a pediatric famous classical formula in traditional Chinese medicine(TCM) specializing in clearing the heart, disinhibiting water and enriching Yin, which has been inherited and developed by medical experts of successive generations. The formula can be traced back to Xiaoer Yaozheng Zhijue written by QIAN Yi from Song dynasty, and most of the later-developed Daochisan(Daochitang) is based on this formula with additions and subtractions. So as to promote the literature excavation of this formula, this paper conducts a thorough textual research and analysis of the composition, processing, preparation methods, clinical applications of Daochisan based on a systematic collation of relevant ancient and modern literature in the method of bibliometrics. A total of 127 pieces of data involving 86 antient TCM books were collected. Statistical analysis showed that the drug origin of Daochisan is basically clear, we suggest that Rehmanniae Radix is the root tuber of Rehmannia glutinosa of Scrophulariaceae, Akebiae Caulis is the dry stem of Akebia quinata of Lardizabalaceae, Glycyrrhizae Radix et Rhizoma is the dry root and stem of Glycyrrhiza uralensis of legume, bamboo leaf is the dry leaves of Phyllostachys nigra var. henonis of gramineous plants. Four herbs are recommended to use its raw products. The key information of the dosage and decocting method is supposed to be "4.13 g each of raw Rehmanniae Radix, raw Glycyrrhizae Radix et Rhizoma, Akebiae Caulis, adding 300 mL of water, and then adding 4.13 g of bamboo leaf, decocting together to 150 mL, taking warmly after meal". Daochisan has the effect of clearing the heart and enriching Yin, disinhibiting water and relieving stranguria, and is widely used in treating symptoms such as heart vexed hotness, hydrodipsia and reddish complexion. Modern studies have showed that Daochisan are frequently used in treating oral ulcer, herpetic stomatitis, urinary tract infection, herpes zoster and other diseases. The above research results can provide scientific reference for the future development and research of Daochisan.
2.Textual Analysis of Classic Formulas Yinchenhao Tang Based on Ancient and Modern Literature
Qing HE ; Lyuyuan LIANG ; Jialei CAO ; Yulu BIAN ; Bingqi WEI ; Chongyi HUANG ; Hejia WAN ; Bingxiang MA ; Wenli SHI
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(12):158-165
Yinchenhao Tang has definite clinical efficacy. It has been inherited and documented since the ancestor of Shanghanlun in the Eastern Han dynasty and is a classical formulas for clearing away heat, promoting diuresis, and eliminating jaundice adopted by medical experts of successive generations. It has been included in the Catalogue of Ancient Classical Formulas (the Second Batch of Han Medicine) published by the National Administration of Traditional Chinese Medicine (TCM) in 2023. By means of bibliometrics, 801 pieces of ancient literature data related to Yinchenhao Tang were collected, and 36 pieces of effective data were selected, involving 36 ancient books of TCM. The origin, name, composition, efficacy, formula and meaning analysis, drug origin, dosage, preparation method and usage, indications, and modern clinical application of Yinchenhao Tang were analyzed. It was suggested that the modern dosage and application of Yinchenhao Tang should be as follows: The 82.8 g of Artemisiae Scopariae Herba, 12.6 g of Gardeniae Fructus, and 27.2 g of Rhei Radix et Rhizoma. The formulas was prepared by firstly adding 2 400 mL of water into Artemisiae Scopariae Herba and boiling it to about 1 200 mL, then adding Gardeniae Fructus and Rhei Radix et Rhizoma to boil it for 600 mL, and removing the residue. It could be orally taken for 200 mL each time in warm conditions, three times a day. Yinchenhao Tang has the effect of clearing away heat, promoting diuresis, and eliminating jaundice, and it mainly treats symptoms of hygropyretic jaundice. In the formulas, Yinchenhao Tang is the monarch drug, which is mainly to remove dampness and jaundice. Gardeniae Fructus is the ministerial drug, which is mainly responsible for clearing the triple energizer and facilitating urination. Rhei Radix et Rhizoma is an adjuvant, mainly responsible for clearing away heat and eliminating jaundice. The modern application of this formulas involves the hepatobiliary system, skin system, endocrine system, digestive system, etc., and it has more advantages in treating jaundice, icteric hepatitis, and hepatitis B. In this study, the ancient literature related to Yinchenhao Tang was sorted out to determine its key information, so as to provide a scientific reference for clinical application of classic formulas and new drug development.
3.Textual Research on Historic Evolution and Ancient and Modern Application of Classic Prescription Huangqintang
Yuxin LI ; Lyuyuan LIANG ; Jialei CAO ; Tongyi HUANG ; Hejia WAN ; Bingqi WEI ; Mengting ZHAO ; Xiaoyang TIAN ; Bingxiang MA ; Weili DANG
Chinese Journal of Experimental Traditional Medical Formulae 2025;31(3):184-191
Huangqintang, with its accurate efficacy, is a classic formula specialized in treating dysentery recommended and promoted by medical experts from successive generations, and it was included in the Catalogue of Ancient Classic Prescriptions (the Second Batch, Han Chinese medicine prescriptions) published by the National Administration of Traditional Chinses Medicine (TCM) in 2023. The method of bibliometrics was applied in this study to conduct textual research on the classic formula Huangqintang and provide a literature reference for the development of modern preparations of Huangqintang. A total of 2 026 pieces of ancient literature were searched with "Huangqintang" as the key word, and 23 pieces of effective data were selected, involving 15 ancient TCM books. The historic evolution, composition, dosage, origin, processing methods, preparation and decocting methods, efficiency, and application of Huangqintang were carefully reviewed. The results showed that Huangqintang was first recorded in the Treatise on Febrile Diseases written by ZHANG Zhongjing. It has the effect of clearing heat, stopping dysentery, regulating the middle, and downbearing counterflow and has become one of the classic formulas widely used in clinical practice. Because of its accurate efficacy, medical experts from later generations have modified it from its original composition. Though many prescriptions have different names, it is the manifestation of physicians' inheritance and development of the thought of ZHANG Zhongjing. Ancient literature showed this prescription had wide indications yet centered on digestive system diseases such as dysentery and abdominal pain. Modern applications of Huangqintang involve digestive, respiratory, ophthalmology and otolaryngology, gynecological, skin, musculoskeletal system, and connective tissue, and this prescription has great potential in treating ulcerative colitis, diarrhea, acute enteritis, and damp-heat dysentery. Through a systematic textual excavation and review of the ancient literature about Huangqintang, the paper has confirmed its key information, so as to provide a scientific basis for the clinical application and new drug development of classic formulas.
4.Textual Research on Classical Formula Juanbitang
Lyuyuan LIANG ; Jinyan ZHANG ; Jialei CAO ; Hejia WAN ; Tongyi HUANG ; Mengmeng GENG ; Bingqi WEI ; Bingxiang MA ; Yajing HE
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(24):190-197
This paper discussed the historic evolution of Juanbitang and similar decoctions, clarified the historic development of Yangshi Juanbitang and Chengshi Juanbitang, and probed into the key information of the meaning, original plants, processing methods, and modern dosage and usage of Chengshi Juanbitang. A total of 267 pieces of relevant information were collected from ancient traditional Chinese medicine (TCM) books, among which 53 pieces of effective data were included in this study. The results showed that both Chenshi Juanbitang and Yangshi Juanbitang were originated from Duhuo Jishengtang recoded in the Important Prescriptions Worth a Thousand Gold for Emergency (Bei Ji Qian Jin Yao Fang). According to the standard of "1 qian roughly equals 3.73 g" in the measurement system of the Qing Dynasty, we suggest Chenshi Juanbitang is composed of 3.73 g Notopterygii Rhizoma et Radix, 3.73 g Angelicae Pubescentis Radix, 3.73 g Gentianae Macrophyllae Radix, 11.19 g Angelicae Sinensis Radix, 11.19 g Mori Ramulus, 2.61 g Chuanxiong Rhizoma, 1.87 g Cinnamomi Cortex, 1.87 g stir-fried Glycyrrhizae Radix et Rhizoma, 7.46 g Piperis Kadsurae Caulis, 2.98 g Olibanum, and 2.98 g Aucklandiae Radix, which should be decocted with 600 mL water to reach a volume of 300 mL. The decoction should be taken 3 times a day before meals. Juanbitang, a classical formula specialized for treating impediment diseases, has the effects of dispelling wind, removing dryness, and alleviating impediment to relieve pain. It can be used for treating vexing pain in body, spasm of nape and back, and heaviness in waists and legs. Modern studies have shown that Juanbitang can be used for treating rheumatoid arthritis, knee osteoarthritis, and periarthritis of shoulder. The above results served as a reference for the future development of Juanbitang.
5.Key Information Research and Contemporary Research Progress of Classical Formula Jinlingzi San
Yizhen WANG ; Lyuyuan LIANG ; Jialei CAO ; Yihang LIU ; Rongze MA ; Zhengshao ZHANG ; Jing TANG ; Bingqi WEI ; Chongyi HUANG ; Hejia WAN ; Bingxiang MA ; Wenli SHI
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(24):215-223
Jinlingzi San is a formula frequently used in treating pain syndrome, first recorded in the Collection of Writings on the Mechanism of Disease, Suitability of Qi, and the Safeguarding of Life as Discussed in the 'Basic Questions' written by LIU Wansu in the Jin Dynasty. Jinlingzi San is composed of 2 Chinese medicinals Toosendan Fructus and Corydalis Rhizoma with a concise composition and exact clinical efficacy, having been included in the Catalogue of Ancient Classical Formulas (Second Batch: Han Chinese Medicine). The formula name, historic evolution, medicine origins, composition, dosage, decocting methods, and ancient and modern clinical application were sorted out and analyzed with the bibliometric method. A total of 209 pieces of information were collected from ancient books and literature. After screening, 49 pieces of effective data involving 45 ancient books were included. Results showed that the name of Jinlingzi San was first recorded in Secret Formulas of the Yang Family written by Yang Tan in the Southern Song Dynasty and developed into 3 other versions of the decoction. The Jinlingzi San included in the Collection of Writings on the Mechanism of Disease, Suitability of Qi, and the Safeguarding of Life as Discussed in the 'Basic Questions' written by LIU Wansu invariably plays a dominant role. As for the 3 other versions, although they have the same name of Jinlingzi San, their composition and indications are different from those of the original formula, which were therefore viewed as prescriptions based on Jinlingzi San and also included in the research. The medicine origins and processing of Jinlingzi San are suggested: Toosendan Fructus is the dry mature fruit of Melia toosendan of Meliaceae, and the crude is used after cleansing without putamen. Corydalis Rhizoma is the dry tuber of Corydalis yanhusuo of Papaveraceae, which is used after impurity removal, cleaning, and drying. Depending on the conversion from the measurement system in the Jin Dynasty to modern measurement, it is suggested that Toosendan Fructus and Corydalis Rhizoma (41.3 g each) are ground into fine powder, and one dose includes 12.39 g of the powder, which should be taken with an appropriate amount of wine. If wine is not suitable for the patient, the decoction can also be taken with warm water. Jinlingzi San has the effects of soothing the liver, discharging heat, and activating blood to stop pain. As recorded in ancient books, Jinlingzi San is specialized in treating heart pain caused by reversal heat, chest and abdominal pain, hypochondriac pain, jaundice, hernia, and other diseases. Modern studies have shown that modified Jinlingzi San can be used in treating diseases involving the digestive system, the integumentary system, the gynecological system, the reproductive system, and other systems and has wide clinical application in treating epigastric pain, herpes zoster, dysmenorrhea, and other diseases. This study has made clear the key information of Jinlingzi San by textual research of ancient books and literature in the hope of providing a theoretical reference for the clinical application, set prescriptions, and new drug development.