1.Trends in Antibiotic Use in a Single University Hospital.
Kang Il JUN ; Hei Lim KOO ; Min Kyung KIM ; Chang Kyung KANG ; Min Jae KIM ; Shin Hye CHUN ; Jung Sook SONG ; Hyang Sook KIM ; Nam Joong KIM ; Eui Chong KIM ; Myoung Don OH
Korean Journal of Nosocomial Infection Control 2013;18(2):44-50
BACKGROUND: The aim of this study was to evaluate antibiotic consumption by adult patients at a single university hospital in Korea between 2001 and 2012. METHODS: We used the 2004 World Health Organization Anatomical Therapeutic Chemical Classification System definition of defined daily doses (DDD) per 1,000 patient-days to calculate the annual antibiotic consumption for 18 antibiotic groups. Chi-square linear-by-linear analysis was performed to evaluate antibiotic consumption trends for each group. RESULTS: Average annual antibiotic consumption during 2001-2012 was 644.6 DDD/1,000 patient-days (standard deviation, 33.3 DDD/1,000 patient-days). Although no statistically significant change was observed during the study period, consumption of first- and second-generation cephalosporins, and aminoglycosides was significantly decreased, while that of beta-lactam/beta-lactamase inhibitors, fourth-generation cephalosporins, carbapenem, glycopeptide, linezolid, colistin, and quinolone increased significantly. CONCLUSION: The total amount of prescribed antibiotics did not change, but the use of broad-spectrum antibiotics increased during the study period.
Adult
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Aminoglycosides
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Anti-Bacterial Agents
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Cephalosporins
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Classification
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Colistin
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Hospitals, University
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Humans
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Korea
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World Health Organization
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Linezolid