1.Expression of Superoxide Dismutase Isoforms in Inflamed Gingiva.
Hei Jin NA ; Ok Su KIM ; Byung Ju PARK
The Journal of the Korean Academy of Periodontology 2006;36(1):97-112
No abstract available.
Gingiva*
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Periodontitis
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Protein Isoforms*
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Superoxide Dismutase*
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Superoxides*
2.Over-expression of extracellular superoxide dismutase in mouse synovial tissue attenuates the inflammatory arthritis.
Dong Hoon YU ; Jun Koo YI ; Hyung Soo YUH ; Seo jin PARK ; Hei Jung KIM ; Ki Beom BAE ; Young Rae JI ; Na Ri KIM ; Si Jun PARK ; Do Hyung KIM ; Sung Hyun KIM ; Myoung Ok KIM ; Jeong Woong LEE ; Zae Young RYOO
Experimental & Molecular Medicine 2012;44(9):529-535
Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular-superoxide dismutase (EC-SOD) and inflammatory arthritis have been shown in several animal models of RA. However, there is a question whether the over-expression of EC-SOD on arthritic joint also could suppress the progression of disease or not. In the present study, the effect on the synovial tissue of experimental arthritis was investigated using EC-SOD over-expressing transgenic mice. The over-expression of EC-SOD in joint tissue was confirmed by RT-PCR and immunohistochemistry. The degree of the inflammation in EC-SOD transgenic mice was suppressed in the collagen-induced arthritis model. In a cytokine assay, the production of pro-inflammatory cytokines such as, IL-1beta, TNFalpha, and matrix metalloproteinases (MMPs) was decreased in fibroblast-like synoviocyte (FLS) but not in peripheral blood. Histological examination also showed repressed cartilage destruction and bone in EC-SOD transgenic mice. In conclusion, these data suggest that the over-expression of EC-SOD in FLS contributes to the activation of FLS and protection from joint destruction by depressing the production of the pro-inflammatory cytokines and MMPs. These results provide EC-SOD transgenic mice with a useful animal model for inflammatory arthritis research.
Animals
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Arthritis, Experimental/blood/*enzymology/metabolism
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*Arthritis, Rheumatoid/enzymology/pathology
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Fibroblasts/metabolism
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Gene Expression Regulation
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Inflammation/pathology
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Interleukin-1beta/blood/metabolism
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Joints/enzymology/pathology
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Matrix Metalloproteinases/blood/metabolism
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Mice
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Mice, Transgenic
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Reactive Oxygen Species/metabolism
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*Superoxide Dismutase/genetics/metabolism
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Synovial Fluid/*enzymology
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Synovial Membrane/pathology
3.Sigmoid Diverticular Bleeding Detected by Capsule Endoscopy.
Youn Ju NA ; Ki Nam SHIM ; Min Jung KANG ; Ji Min JUNG ; Hae Sun JUNG ; Su Jung BAIK ; Su Jin YOUN ; Hyun Joo SONG ; Kum Hei RYU ; Hye Jung YEOM ; Tae Hun KIM ; Sung Ae JUNG ; Kwon YOO ; Il Hwan MOON ; Kyu Won CHUNG
Korean Journal of Gastrointestinal Endoscopy 2007;35(1):56-59
Colonic diverticulosis is small outpouching from the lumen of the colon, and this caused by mucosal herniation. Most patients are asymptomatic, but 5~15% of those affected manifest diverticular bleeding. Because most of them stop bleeding spontaneously, the source of the bleeding can not be found by colonoscopy in 15% of these cases. We report here on a case of sigmoid diverticular bleeding that detected by capsule endoscopy in a 68-year old woman who presented with acute obscure gastrointestinal bleeding.
Aged
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Capsule Endoscopy*
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Colon
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Colon, Sigmoid*
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Colonoscopy
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Diverticulosis, Colonic
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Female
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Hemorrhage*
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Humans