1.Differences in Dietary Intake and Life-style of Female College Students in Seoul with and without Premenstrual Syndrome.
The Journal of Korean Society of Menopause 2010;16(3):153-161
OBJECTIVES: We examined the association between premenstrual syndrome (PMS) and dietary intake and lifestyle risk factors of 203 female college students in Seoul. METHODS: PMS was diagnosed using the Menstrual Distress Questionnaire (MDQ), and dietary intake was accessed by a food frequency questionnaire. RESULTS: Fifteen percent of students were diagnosed with PMS; there were no significant differences with respect to age, height, weight, and body mass index (BMI) of the students with and without PMS symptoms. Students with PMS recognized their PMS symptoms, experienced significantly more severe PMS symptoms, and received more treatment and had more stress compared with students without PMS. Interestingly, students with PMS had greater alcohol intake and consumed more animal calcium than students with PMS. However, the intake of other nutrients was not significantly different between students with and without PMS. CONCLUSION: Out data suggest that students with PMS should increase intake of animal calcium and find ways to reduce stress.
Animals
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Body Mass Index
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Calcium
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Female
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Humans
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Life Style
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Premenstrual Syndrome
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Risk Factors
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Surveys and Questionnaires
2.Eating Attitudes, Depression, Parent-child Interaction, and Family Function of Adolescent Girls.
Suyon BAEK ; Jiyoung PARK ; Heesoon KIM ; Taehyung KIM
Journal of Korean Academy of Psychiatric and Mental Health Nursing 2012;21(3):176-187
PURPOSE: The purpose of the study was to investigate the prevalence of abnormal eating attitudes and to identify possible risk factors associated with these attitudes among Korean adolescent girls. METHODS: A convenience sample of 1,126 girls aged 15 to 19 years was recruited from thirteen high schools. A self-report survey was conducted including Eating Attitude Test for diagnosing abnormal eating attitudes. Data were analyzed using descriptive statistics and multiple logistic regression with PASW statistics 18.0. RESULTS: Of the participants, 8.3% met the criteria for abnormal eating attitudes. Misperception of body image, depression, and high or low economical status were significantly associated with abnormal eating attitudes (OR=3.50, 95% CI=1.95~6.28; OR=5.47, 95% CI=3.17~9.44; OR=2.26, 95% CI=1.14~4.47; OR=2.41, 95% CI=1.25~4.66). CONCLUSION: The current study identified the family factors as well as internal ones related to abnormal eating attitudes of Korean adolescent girls. The results indicate that the most effective prevention strategies for this population would be to correct their misperception of body image and control depression. Results also suggest that further studies are necessary to develop a predictive model that could explain the influence of family factors including parent-child interaction and family function to abnormal eating attitudes.
Adolescent
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Aged
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Body Image
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Depression
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Eating
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Feeding and Eating Disorders
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Humans
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Logistic Models
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Parent-Child Relations
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Prevalence
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Risk Factors
3.Somatostatin Receptor.
Eunhee KIM ; Sookjin SOHN ; Mina LEE ; Heesoon PARK ; Jeechang JUNG ; Seungjoon PARK
Journal of Korean Society of Endocrinology 2003;18(4):342-355
No abstract available.
Receptors, Somatostatin*
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Somatostatin*
4.Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) mRNA Levels by Growth Hormone (GH) -Releasing Hormone in Purified Somatotropes.
Seungjoon PARK ; Heesoon PARK ; Mina LEE ; Sookjin SOHN ; Eunhee KIM ; Jeechang JUNG ; Lawrence A FROHMAN ; Rhonda D KINEMAN
The Korean Journal of Physiology and Pharmacology 2003;7(2):79-84
We have previously reported that expression of the somatostatin receptor subtypes, sst1-5, is differentially regulated by growth hormone (GH) -releasing hormone (GHRH) and forskolin (FSK), in vitro. GHRH binds to membrane receptors selectively located on pituitary somatotropes, activates adenylyl cyclase (AC) and increases sst1 and sst2 and decreases sst5 mRNA levels, without significantly altering the expression of sst3 and sst4. In contrast FSK directly activates AC in all pituitary cell types and increases sst1 and sst2 mRNA levels and decreases sst3, sst4 and sst5 expression. Two explanations could account for these differential effects: 1) GHRH inhibits sst3 and sst4 expression in somatotropes, but this inhibitory effect is masked by expression of these receptors in unresponsive pituitary cell types, and 2) FSK inhibits sst3 and sst4 expression levels in pituitary cell types other than somatotropes. To differentiate between these two possibilities, somatotropes were sequentially labeled with monkey anti-rat GH antiserum, biotinylated goat anti-human IgG, and streptavidin-PE and subsequently purified by fluorescent-activated cell sorting (FACS). The resultant cell population consisted of 95% somatotropes, as determined by GH immunohistochemistry using a primary GH antiserum different from that used for FACS sorting. Purified somatotropes were cultured for 3 days and treated for 4 h with vehicle, GHRH (10 nM) or FSK (10micrometer). Total RNA was isolated by column extraction and specific receptor mRNA levels were determined by semi-quantitative multiplex RT-PCR. Under basal conditions, the relative expression levels of the various somatostatin receptor subtypes were sst2> sst5> sst3=sst1> sst4. GHRH treatment increased sst1 and sst2 mRNA levels and decreased sst3, sst4 and sst5 mRNA levels in purified somatotropes, comparable to the effects of FSK on purified somatotropes and mixed pituitary cell cultures. Taken together, these results demonstrate that GHRH acutely modulates the expression of all somatostatin receptor subtypes within GH-producing cells and its actions are likely mediated by activation of AC.
Adenylyl Cyclases
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Cell Culture Techniques
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Colforsin
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Goats
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Growth Hormone*
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Haplorhini
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Immunoglobulin G
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Immunohistochemistry
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Masks
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Membranes
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Receptors, Somatostatin*
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RNA
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RNA, Messenger*
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Somatostatin*
5.Neuroprotective and Antioxidant Effects of Novel Benzofuran-2-Carboxamide Derivatives.
Jungsook CHO ; Chowee PARK ; Youngmun LEE ; Sunyoung KIM ; Shambhunath BOSE ; Minho CHOI ; Arepalli Sateesh KUMAR ; Jae Kyung JUNG ; Heesoon LEE
Biomolecules & Therapeutics 2015;23(3):275-282
In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat cortical neuronal cells and in vitro cell-free bioassays. Based on our primary screening data with eighteen synthesized derivatives, nine compounds (1a, 1c, 1f, 1i, 1j, 1l, 1p, 1q and 1r) exhibiting considerable protection against the NMDA-induced excitotoxic neuronal cell damage at the concentration of 100 muM were selected for further evaluation. Among the selected derivatives, compound 1f (with -CH3 substitution at R2 position) exhibited the most potent and efficacious neuroprotective action against the NMDA-induced excitotoxicity. Its neuroprotective effect was almost comparable to that of memantine, a well-known NMDA antagonist, at 30 muM concentration. In addition to 1f, compound 1j (with -OH substitution at R3 position) also showed marked anti-excitotoxic effects at both 100 and 300 muM concentrations. These findings suggest that -CH3 substitution at R2 position and, to a lesser degree, -OH substitution at R3 position may be important for exhibiting neuroprotective action against excitotoxic damage. Compound 1j was also found to scavenge 1,1-diphenyl-2-picrylhydrazyl radicals and inhibit in vitro lipid peroxidation in rat brain homogenate in moderate and appreciable degrees. Taken together, our structure-activity relationship studies suggest that the compound with -CH3 substitution at R2 and -OH substitution at R3 positions of the benzofuran moiety might serve as the lead exhibiting potent anti-excitotoxic, ROS scavenging, and antioxidant activities. Further synthesis and evaluation will be necessary to confirm this possibility.
Animals
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Antioxidants*
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Biological Assay
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Brain
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Lipid Peroxidation
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Mass Screening
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Memantine
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N-Methylaspartate
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Neurons
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Neuroprotective Agents
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Rats
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Reactive Oxygen Species
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Structure-Activity Relationship