In our time the parent's role is changing from sexually differentiated to androgynous pattern. Mother's interaction with infant includes caring and father's interaction especially have play. Father and mother share the caring and play because they have complementary nature. Infants have a tendency to show more positive responses to their fathers than mothers in play situations. For that reason we can help the promotion of father's interaction with his infant. through ascertaining patterns of father-infant play interaction. This study was to find out patterns of father-infant play interaction in order to improve the interaction between father and infant. Data was video-taped from 6 fathers and infants who were healthy and first-timed and 7-11 weeks old in their houses. I used Father-Infant Play Interaction Scale that was applied to father instead of mother as a care-giver. The scale was checked up by experts in this field for content validity and the reliability was 0.95 in this study. The results were as follows; 1. Father's play behaviors were the patterns of responses about infant's cue. The mean score was 33.16(SD, 9.11). This mean they come up to the standard level of responses about infant's cue. 2. Infant's play behaviors were the patterns of responses about father's cue. The mean score was 7.00(SD, 3.10). This means they get the higher level of responses about father's cue. 3. The patterns of simultaneous responses occurred together between father and infant. The mean score was 9.58(SD, 3.96). This means they reach the standard level of simultaneous responses between father and infant. 4. The patterns of interactional behaviors occurred interpersonally between father and infant. The mean score was 49.75(SD, 15.80). This means they interact on the standard level of play interaction. In view of the results father's play interaction seems to reveal an average level and play patterns are similar to mother's. In order to ascertain definitely patterns of father-infant play interaction we need further research which has more subjects and variables to have important effects.
Cues ; Fathers ; Humans ; Infant ; Mothers ; Pilot Projects* ; Child Health

PURPOSE: The purpose of this study was to identify the risk factors that influence surgical site infections after surgery. METHODS: This study was a retrospective research utilizing Electronic Medical Records. Data collection targeted 4,510 adult patients who had 8 different kinds of surgery (gastric surgery, colon surgery, laparoscopic cholecystectomy, hip & knee replacement, hysterectomy, cesarean section, cardiac surgery) in 4 medical care departments, at one general hospital between January 2006 and December 2011. Multivariate logistic regression analyses were used to identify the risk factors affecting surgical site infections after surgery. RESULTS: Risk factors for increased surgical site infection following surgery were confirmed to be age (OR=1.59, p<.001), BMI (Body Mass Index)(OR=1.25, p=.034), year of operation (OR=2.45, p<.001), length of operation (OR=3.06, p<.001), ASA (American Society of Anesthesiology) score (OR=1.36, p=.025), classification of antibiotic used (OR=2.77, p<.001), duration of the prophylactic antibiotics use (OR=1.85, p<.001), and interaction between classification of antibiotic used and duration of the prophylactic antibiotics use (OR=1.90, p=.016). CONCLUSIONS: Results suggest that risk factors affecting surgical site infections should be monitored before surgery. The results of this study should contribute to establishing effective infection management measures and implementing surveillance systems for patients who have actual risk factors.
Adult ; Anti-Bacterial Agents ; Cesarean Section ; Cholecystectomy ; Classification ; Colon ; Surveys and Questionnaires ; Electronic Health Records* ; Female ; Hip ; Hospitals, General ; Humans ; Hysterectomy ; Knee ; Laparoscopy ; Logistic Models ; Pregnancy ; Retrospective Studies ; Risk Factors* ; Surgical Wound Infection

BACKGROUND: Interleukin-18 (IL-18) is one of the principal inducers of interferon-gamma (IFN-gamma) in lymphocytes. MATERIALS AND METHODS: The effect of IL-18 on the expression of chemokine IP-10(CXCL10) mRNA in C57BL/6 mouse peritoneal macrophages was studied by using Northern blot analysis, enzyme linked immunosobent assay and electrophoretic mobility shift assay. RESULTS: IL-18 was determined to exert no direct effect on the expression of IP-10(CXCL10) mRNA. However, IL-18 pretreatment was determined to play a cooperative role in the synergistic induction of LPS-induced IP-10(CXCL10) mRNA expression. The effect associated with IL-18 pretreatment with regard to the synergistic induction of LPS-induced IP-10 (CXCL10) mRNA expression was detected after 16 hr of IL-18 pretreatment, administered prior to LPS stimulation. The pattern of NF-kB binding activity during IL-18 pretreatment with LPS stimulation was found to coincide with the expression of IP-10(CXCL10) mRNA. CONCLUSION: Although IL-18 alone exerts no direct effect on the expression of chemokine IP-10(CXCL10), a definite period of IL-18 pretreatment induces the synergistic expression of LPS-induced IP-10(CXCL10) mRNA. NF-kB activation is a component of this synergistic effect of IL-18 pretreatment. These results provide useful information, which may facilitate the elucidation of the action mechanisms underlying IL-18 effect on the expression of IP-10(CXCL10) mRNA.
Animals ; Blotting, Northern ; Electrophoretic Mobility Shift Assay ; Interferon-gamma ; Interleukin-18* ; Lymphocytes ; Macrophages, Peritoneal ; Mice ; NF-kappa B ; RNA, Messenger* ; Up-Regulation*

PURPOSE: To evaluate the predictive factors of radiation pneumonitis (RP) and associated changes in pulmonary function after definitive concurrent chemoradiotherapy (CCRT) in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Medical records of 60 patients with NSCLC who received definitive CCRT were retrospectively reviewed. Dose volumetric (DV) parameters, clinical factors, and pulmonary function test (PFT) data were analyzed. RP was graded according to the CTCAE ver. 4.0. Percentage of lung volume that received a dose of threshold (Vdose) and mean lung dose (MLD) were analyzed for potential DV predictors. PFT changes were calculated as the difference between pre-RT and post-RT values at 3, 6, and 12 months after RT. RESULTS: Twenty-two patients (37%) developed grade > or =2 RP. Among clinical factors, tumor location in lower lobe was associated with RP. Among the DV parameters, only MLD >15 Gy was associated with grade > or =2 RP. There were statistically significant decreases in PFT at all points compared with pre-RT values in grade > or =2 RP group. MLD was associated with forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) changes at 6 and 12 months. V10 was associated with FVC changes at 12 months. V20 and V30 were associated with FEV1 changes at 6 months and FVC changes at 12 months. CONCLUSION: After definitive CCRT in patients with NSCLC, MLD >15 Gy and lower lobe tumor location were predictors of grade > or =2 RP. Pulmonary functions were decreased after CCRT and the magnitude of changes was associated with DV parameters.
Carcinoma, Non-Small-Cell Lung ; Chemoradiotherapy ; Forced Expiratory Volume ; Humans ; Lung ; Medical Records ; Radiation Pneumonitis ; Respiratory Function Tests ; Retrospective Studies ; Vital Capacity

Erythropoietin is the major hormonal regulator of erythropoiesis. It is controlled by many factors inducing hypoxia in tissue. The serum erythropoietin levels of neonates have shown gradual dccrease until 1 month of age, which they are reactivated in the period of physiologic anemia. This change is exaggerated if the meonates are born prematurely, and the levels of erythropoietin respond to lower hemoglobin are lower than those of term neonates and adults. The purpose of this study was to assess the values of erythropoietin levels to compare hemoglobin on the preterm and term neonates until 1 month of age. The results were as follows: 1) At birth mean erythropoietin values of preterm and term neonates were 16.5+/-1.4mU/ml, 16.5+/-1.7mU/ml respectively, there was no significant difference. Also erythropoietin values in preterm and term neonates were 23.6+/-13.3mU/ml, 10.9+/-1.5mU/ml respectively. Resticulocyte counts in preterm and term neonates were 10.7+/-3.3%, 5.7+/-2.9% respectively, so they were significantly higher in preterm than in term neonates. 2) The changes of mean hemoglobin, reticulocyte counts and erythropoietin according to postnatal ages were that those of reticulocyte counts and erythropoietin were significantly increased about 1 month of age. 3) At the 1 month of age, mean erythropoietin values in preterm neonates were lower than those of term neonates and adults, despite of the lowest hemoblobin. This results showed that erythropoietin values in preterm neonates during the physilolgic anemia were lower values than those of term neonates and adults in spite of the lowest hemoglobin.
Adult ; Anemia ; Anoxia ; Erythropoiesis ; Erythropoietin* ; Humans ; Infant, Newborn* ; Parturition ; Reticulocyte Count

No abstract available.
Adult* ; Doxycycline ; Humans ; Tooth*

Identification of virus is very importnant in aspects of preventive surveillance system of viral infection. The first isolation of echovirus serotype 25 from hand, foot and mouth disease was accomplished in Pusan, 1998. The authors determined some properties of this virus. Two cases of outbreak were confirmed from the stools of a 3 year-old girl and one 4 year-old boy suffering from hand, foot and mouth disease. Both occurred in April. The isolated viruses showed strong cytopathic effect on RD cells, also on HEp-2, and Vero cell lines after 3 days at 34'C, CO incubation. Isolated virus was identified as echovirus serotype 25 by neutralizing antibody test. Electron micrograph of negative-stained echovirus serotype 25 showed non-enveloped, isometric particle and about 30 nm in diameter.
Animals ; Antibodies, Neutralizing ; Busan* ; Child, Preschool ; Enterovirus B, Human* ; Female ; Foot* ; Foot-and-Mouth Disease* ; Hand* ; Hand, Foot and Mouth Disease ; Humans ; Male ; Vero Cells

The purpose of this study was to explore and describe the lived experience of the family caregivers with the demented elderly. For investigate purposes of this study, data collection was done from May 9th to October 16th 1997, by means of in-depth interviews with 6 individuals in caregiving families. The research question was "What are the lived experiences of being a family caregiver with the demented elderly? "All interviews were tape-recorded and transcribed for the analysis using Colaizzi's method. The main results of this study were as follows : 1) Family caregivers ascribed the cause of the dementia to 'environmental change' and the 'introverted personality of the elderly'. 2) Family caregivers let the demented elderly alone initially and then they restrained the elderly who was in a fit of dementia. 3) The coping response of family caregivers varied. The coping reponses were (1) having their moods go up and down, (2) enduring and praying, (3) avoiding the elderly, (4) hoping for release from responsibility, (5) enduring their conditions(obligations), (6) accepting the elderly, (7) taking an objective view, and (8) taking safety measures. 4) The long ordeal of coping with a demented elderly person resulted in the (1) loss of physical and psychological well-being, (2) ethical conflicts, (3) family conflicts, (4) become desperate, (5) rejection of the aging process, (6) sympathy and understanding for the elderly, (7) awareness that the support system is important and (8) hope of sharing their responsibility. The results of this study may help nurses to understand the lived experiences of the family caregivers with the demented elderly better, in order to provide more basic data for the development of educational programs for dementia family caregivers. It may help to make the coping process easier and more successful for the family members of the demented elderly.
Aged ; Aging ; Alzheimer Disease* ; Caregivers* ; Data Collection ; Dementia ; Family Conflict ; Hope ; Humans ; Linear Energy Transfer

BACKGROUND: Myocardial ischemia in human hypertension and in various animal models of hypertension may be due to abnormal maximal coronary vasodilator reserve and disturbaces of coronary vasomotion. The vascular reactivity defects in hypertension have been associated with the defective endothelium and sympathetic neural activation. However, such abnormalities in hypertension need to be elucidated. In the present study the effectsof cardiac ischemia reperfusion on coronary circulation, intramyocytic adenylates and purine nucleosides were examined in Langendorff-perfused Sprague Dawley rat (SD) and spontaneously hypertensive rat (SHR) hearts. Coronary venous and cardiac lactate and cardiac pyruvate were also measured. It should be noted that in the regulation of coronary flow the intrinsic flow autoregulation is highly variable due to coexisting metabolic flow control, and that natural coronary flow and cardiomyocytic energy state are normally reciprocally related in perfused heart. METHODS: For the Langendorff heart perfusion, bicarbonate perfusion buffer (pH 7.40+/-0.02,37degrees C) was equilibrated with 95% O2 : 5% CO2 and contained 5mM glucose (+5U/1 insulin) and 2mM pyruvate as energy-yielding substrates. Global hypoperfusion ischemia was induced by lowering coronary perfusion pressure of 100 to 40 cmH2O, followed by 20 min reperfusion. RESULTS: During the ischemia and reperfusion, metabolic acidosis and enhanced venous lactate output in SHR were observed with increases in coronary vascular resistance and myocardial oxygen consumption.In addition, coronary reactive hyperemia during reperfusion was depressed. Although ischemia-induced increase in combined adenosine plus inosine were abolished during prolonged reperfusion, SD still exhibited coronary vasodilation. The depressed reactive hyperemia in SHR was associated with decreases in cardiac adenosine triphosphate (ATP) pool and creatine phosphate/inorganic phosphate (CrP/Pi) ratio and an increase in cardiac lactate/pyruvate ratio. CONCLUSION: This abnormal vascular reactivity during ischemia and reperfusion in SHR may be in part due to an alteration in the cardiac energy state and hence to a mismatch between myocardial metabolic demand and supply.
Acidosis ; Adenosine ; Adenosine Triphosphate ; Animals ; Coronary Circulation ; Creatine ; Endothelium ; Glucose ; Heart* ; Homeostasis ; Humans ; Hyperemia ; Hypertension ; Inosine ; Ischemia ; Lactic Acid ; Models, Animal ; Myocardial Ischemia ; Oxygen ; Perfusion* ; Purine Nucleosides ; Pyruvic Acid ; Rats ; Rats, Inbred SHR* ; Reperfusion ; Vascular Resistance ; Vasodilation

This study was undertaken to obtain the incidence of dysmenorrhea and differance of dysmenorrhea according to the general characteristics, lifestyle, and menstrual pattern in women community college students. For the data collection, self-administered questionnaire survey was made from April 7, 1999 to April 14, 1999 among the 204 women community college students. The resultant data were processed by SAS program for frequency, proportion, and Chi-square test. The results of this study are as follows ; 1) Prevalence rate of dysmenorrhea was 81.9%. Among women who had dysmenorrhea, 42.6% of them had family history on dysmenorrhea, 47% of them experienced the dysmenorrhea 'monthly', 89.2% of them had experienced dysmenorrhea on the first-second day, 38.5% of them responded that the most painful region was 'low abdomen', 61.5% of them responded that they used 'analgesics' to soothe dysmenorrhea, 92.3% of them responded that they had analgesics without doctor's prescription, and 42.6% of them responded that they experienced digestive system related symptoms during menstrual period. 2) The incidence of dysmenorrhea was significantly different by ordering of sisters, blood type, and body shape. 3) The incidence of dysmenorrhea was no significantly different by life style. 4) The incidence of dysmenorrhea was no significantly different by menstrual pattern.
Analgesics ; Digestive System ; Dysmenorrhea* ; Female ; Female* ; Humans ; Incidence ; Life Style ; Prescriptions ; Prevalence ; Surveys and Questionnaires ; Siblings