1.A Case of Preleukemia Presenting as Aplastic Anemia.
Dong Hee OH ; Sei Hee CHOI ; Baek Keun LIM ; Jong Soo KIM
Journal of the Korean Pediatric Society 1985;28(11):1141-1146
No abstract available.
Anemia, Aplastic*
;
Preleukemia*
2.Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
Jihyun LIM ; Aram LEE ; Hee Gu LEE ; Jong-Seok LIM
Biomolecules & Therapeutics 2020;28(1):1-17
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in the tumor microenvironment and suppress T cell responses via various mechanisms, whereas a reduction in their activities has been observed in autoimmune diseases or infections. It has been reported that the symptoms of various diseases, including malignant tumors, can be alleviated by targeting MDSCs. Moreover, MDSCs can contribute to patient resistance to therapy using immune checkpoint inhibitors. In line with these therapeutic approaches, diverse oligonucleotide-based molecules and small molecules have been evaluated for their therapeutic efficacy in several disease models via the modulation of MDSC activity. In the current review, MDSC-targeting oligonucleotides and small molecules are briefly summarized, and we highlight the immunomodulatory effects on MDSCs in a variety of disease models and the application of MDSC-targeting molecules for immuno-oncologic therapy.
3.A Case of Nephrogenic Diabetes Insipidus Complicated with Bilateral Hydroureteronephrosis and Myogenic Failure of the Bladder.
Seung Dai LIM ; Keung Won PARK ; Hee Kwan RIM ; Jong Sung KIM ; Jung Sik RIM
Korean Journal of Urology 2000;41(5):685-688
No abstract available.
Diabetes Insipidus, Nephrogenic*
;
Urinary Bladder*
4.Cord Plasma Alpha-Fetoprotein Values and Neonatal Jaundice.
Mee Kyung NAMGOONG ; Sei Hee CHOI ; Ae Sook KIM ; Baek Keun LIM ; Jong Soo KIM
Journal of the Korean Pediatric Society 1986;29(8):24-27
No abstract available.
alpha-Fetoproteins*
;
Infant, Newborn
;
Jaundice, Neonatal*
;
Plasma*
5.Effect of oxantel/pyrantel pamoate tablets against intestinal nematodes in Korea.
Han Jong RIM ; Sook Hee LEE ; Sung Ik LEE ; Dong Shik CHANG ; Jung Kyoo LIM
The Korean Journal of Parasitology 1978;16(1):14-20
A total of 48 subjects harbouring Trichuris trichiura, Ascaris lumbricoides, hookworm and/or Enterobius vermicularis were treated with oxantel/pyrantel pamoate tablets (100 mg of each) in a single dose of 20 mg base per kg of body weight. In all 37 cases of A. lumbricoides and 8 cases of A. duodenale infections cured completely, and the mean recovered worm-load was 3.8 with a range of 1-21 and 5.8 with a range of 3-9 respectively. In T. trichiura infection, 32(71.1%) of 45 cases cured completely and the average egg reduction rate was 90.8 per cent. The mean recovered worm-load was 14.6 with a rnage of 1-77 worms. On the other hand, in E. vermicularis infection, 37 (84.1 %) of 44 patients were negative eggs by anal swab tests on the 10 to 11th days and 27 (61.4%) on the 20 to 21st days after treatment. The mean recovered worm-load was 17.7 with a range of 1-62. Only one patient with Trichostrongylus orientalis treated with this drug showed no eggs in his stools throughout the post-treatment examinations. Side effects were not noted in all treated cases. These findings demonstrate that a single dose of oxantel/pyrantel pamoate tablets can be considered a drug of choice for multiple infections with these nematodes.
parasitology-helminth-nematoda
;
Trichuris trichiura
;
Ascaris lumbricoides
;
hookworm
;
Enterobius vermicularis
;
chemotherapy
;
oxantel/pyrantel pamoate
6.Lacrimal canalicular reconstruction with various materials.
Hyung Gon SHIM ; Jun Hee BYEON ; Jong Won RIE ; Chong Kun LEE ; Poong LIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(4):622-627
This retrospective clinical study consists of 27 patients with lacrimal canalicular injury caused by various accidents and which were reconstructed with various materials in the department of plastic surgery at Catholic University Medical College from December 1987 to July 1996. These 27 patients were followed up at least 6 months after the canalicular reconstruction and their medical records were reviewed and analysed retrospectively in order to obtain the clinical pattern and understand the therapeutic results. The statistical items were the age and sex distribution, the causes of injury, the prevalent site of injury, the reconstruction materials, the duration of intubation and the results of treatment. The following results are obtained: 1. Males were more dominant than females by 4.4 : 1. 2. The patient age was from 6 to 73 years old and the prevalent age groups were the third and fourth decades(55.5%). 3. The most common cause of canalicular injury was the violence(29.6%) and was followed by traffic accident. 4. The left canaliculi, especially inferior canaliculi, was the prevalent injury site. 5. Regardless of the materials(P.V.C. tube, nylon and silicone tube) used in canalicular reconstruction, the longer duration of intubation was obtained the better result of treatment. 6. So the silicone tube with stainless steel(C-line canaliculus intubation set) was relatively inert and less complicating, it could be maintained more longer and had better results than other materials such as P.V.C. tube and nylon.
Accidents, Traffic
;
Aged
;
Female
;
Humans
;
Intubation
;
Male
;
Medical Records
;
Nylons
;
Retrospective Studies
;
Sex Distribution
;
Silicones
;
Surgery, Plastic
7.MR appearances of intracranial tumors with a low tesla (0.064 T) permanent MR system.
Hee Jin KIM ; Sun Kyung LIM ; Dae Ik KWON ; Byung Young KIM ; Jong Gil LEE
Journal of the Korean Radiological Society 1993;29(5):869-875
In this report we describe twenty-two cases of intracranial tumors studied with an MR imager operating at a field strength of 0.064 T for evaluation of the clinical utility of low tesla MRI. The comfirmed diagnoses were meningioma(9 cases), astrocytoma(4 cases), glioblastoma multiforme(1 case), craniopharyngioma(2 cases), intracranial metastasis(1 case). pituitary microadenoma (1 case), hemangioblastoma (1 case), and trigerminal neurilemmoma(1 case). Meningiomas appeared as well-marginated, homogenous signal intensity masses(67%) in most cases. Most meningiomas showed iso-signal intensity(78%) on T1-weighted images, and high signal intensity on T2-weighted images. After Gd-DTPA enhancement, diffuse homogeneous contrast enhancement(75%) was well see. The multiple hemorrhagic foci within the glioblastoma multiforme were identified, which shoed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images(intracellular methemoglobin), or high signal intensity on both T1 and T2-weighted images(extracellular methemoglobin). One case of cerebellar hemangioblastoma was a well-defined cystic mass with contrast enhanced mural nodule but no identification of characteristic signal void vessels. The remianing tumors showed low signal intensity on T1-weighted images, and high signal intensity on T2-weighted images. Gd-DTPA enhancement was helpful in separating the lesion from the surrounding edema or normal tissue, but had limited diagnostic value in characterizing the nature of the mass. The advantages of low tesla MRI are as follows on requirement of cooling water or electricity, open design, shorter T1 relaxation time compared with high tesla unit that increases the difference of T1-relaxation time between tissues, ease of installation, and cost effectiveness. In conclusion, the low tesla MRI is useful for the detection and evaluation of the brain tumors.
Brain Neoplasms
;
Cost-Benefit Analysis
;
Diagnosis
;
Edema
;
Electricity
;
Gadolinium DTPA
;
Glioblastoma
;
Hemangioblastoma
;
Magnetic Resonance Imaging
;
Meningioma
;
Relaxation
;
Water
8.Bacteriolysis and variation on the O-side chain lengths of lipopolysaccharides of salmonella typhi Ty21a with respective to the concentrations of galactose.
Jong Bae KIM ; Won Yong LEE ; Sang Hee PARK ; Min Kyung LIM ; Jin Yuen CHANG
Journal of the Korean Society for Microbiology 1992;27(5):419-425
No abstract available.
Bacteriolysis*
;
Galactose*
;
Lipopolysaccharides*
;
Salmonella typhi*
;
Salmonella*
9.Replantation of 135 fingertip amputations.
Joon Hee LEE ; Jae Ho LIM ; Jong Moon LEE ; Woo Kyung KIM ; Chun Eun CHUNG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1993;20(5):1136-1144
No abstract available.
Amputation*
;
Replantation*
10.Chronic Eosinophilic Pneumonia: A Case Report.
Hae Jeong JEON ; Jeong Hee PARK ; Jong Nam LIM ; Tae Haeng HEO ; Hyun Jun SHIN
Journal of the Korean Radiological Society 1995;32(5):733-735
Chronic eosinophilic pneumonia is a rare diasease characterized by chronic infiltration of the lung with ~eosinophils, usually associated with peripheral eosinophilia. In 65% of cases, the chest rad Ogroaph shows typiical nonsegmental air-space consolidation confined to the outer third of the lung and in 25)/0 of case "photographic negative of pulmonary edema". Typical lung manifestations with 'peripheral eosinophiliSa' tahrcharacteristic of chronic eosinophilic pneumonia. In the remaining cases, radiographic findings are nonspecific and require lung biopsy for confirmation. We repot a case of chronic eosinophilic pneumonia in which chest radiograph and CT scans revealed bilateral patchy or diffuse opacity with nodules scattered throughout the lungs.
Biopsy
;
Eosinophilia
;
Eosinophils*
;
Lung
;
Pulmonary Eosinophilia*
;
Radiography, Thoracic
;
Thorax
;
Tomography, X-Ray Computed