Scleroderma is an incidious,chronic disease of unknown causes, and may be defined as a disease complex of vascular changes, fibrosis, and inflammation that to varying iegrees involves skin and visceral organs. But it has been suggested that an autoimmune mechanism is concerned, 20-year-old female was reported that she has been suffering from dysphagia and vomiting after feeding for 3 years. There has been the "salt and pepper" type hypopigmented patches on eatire body except for face, hands, and feet for 13 years. Diagnosis of scleroderma associated with esophageal achalasia are confirmed by clinical findings, histopathological finding, esophagogram, and gastrofibrascopy. Some literatures are briefly reviewed.
Deglutition Disorders ; Diagnosis ; Esophageal Achalasia* ; Female ; Fibrosis ; Foot ; Hand ; Humans ; Inflammation ; Skin ; Vomiting ; Young Adult

424 patients who were consulted to department of dermatology during their admission in Ewha Womans University Hospital from Jan.to Dec. 1991 were analyzed in order to evaluate the tendency of dermatologic problems. The results were as follows: 1. The most frequent dermatologic problem was eczema. 2. Age prevalence was highest between 40-49. 3. The most frequent dermatologic problem was found in spring. 4. The pathents in internal rnedicine were most, frequently consuled. 5. Patients with diabetes mellitus were most frequently consulted among systernic disease. 6. There was no significant difference in sex ratio. 7. The rate of consultation for acne was increased compared to 1976. 8. The rate of cosultatin for fungal infection was increased compared to the frequency rate of fungal infection of new patients at OPD in 1991.
Acne Vulgaris ; Dermatology* ; Diabetes Mellitus ; Eczema ; Female ; Humans ; Inpatients* ; Prevalence ; Sex Ratio

No abstract available.

No abstract available.

Psoriasis is a common chronic recurrent inflammatory disease of the skin characterized by round, circumscribed, erythematous dry scaling patches of various sizes, covered by grayish white or silvery white, imbricated and lamella scales. The number of psoriasis have tendency to increase on these days in Korea. To evaluate a general tendency of psoriasis at the Department of Dermatology, College of Medicine in Ewha Womans University in 1982, 281 cases of psoriasis at OPD were analized by the clinical data. The results were as follows: 1. Male incidence was 122(43.4%) and female 159(56.6%) out of 281 cases of psoriasis. There is no signiifcant sex differences(M:F 1:1.3). 2. The peak incidence of age group was aged between 20 to 29(33.1%). The incidence under 20 was 15.3%. Mosi: of the patients(68.0%) was aged between 20 and 49. R. The most frequent site of involvement was on the entire body(47.7%). Frequent involved site in descending order were lower extremities, upper extremities, scalp, elbows and knees. 4. There was no significant seasonal variation in psoriasis in 1982(Spring: 26. 7%., Summer: 25.6%, Fall: 18.5% Winter: 29.2g). 5. The incidence of psoriasis in 1982 at OPD of Ewha Womans University hospital was 1.95% in total new patient of 14,424.
Dermatology ; Elbow ; Female ; Humans ; Incidence ; Knee ; Korea ; Lower Extremity ; Male ; Psoriasis* ; Scalp ; Seasons ; Skin ; Upper Extremity ; Weights and Measures

No abstract available.

Port-wine stains (PWSs) are benign congenital vascular malformations that most commonly occur as isolated lesions on the face, neck and trunk. The major indication for therapy in most patient, regardless of age, is psychological burden imposed by the PWSs. A Candela SPTL-1 flashlamp-pumped pulsed dy laser (Candela Corp. Wayland, Mass.) using the principle of selective photothermolysis was used. Selective cutaneous vascular damages are influenced by the wavelength. pulse duration and energy density of the laser. To evaluate histopathological changes according to energy densities are essential to treat cutaneous benign vascular lesion by the iaser. 5 patients with PWSs were treated with the Candela SPTL-1 laser. Lesions were biopsied and analized immediately after laser exposure. 2 days and 7 days after laser exposure. The results were as follows : 1. Depth of penetration The penetration depth was increased from .2mm to 1.9mm with energies ranging from 6J/cm(2) to 10J/cm(2) respectively. 2. Nonvascular damages of epidermis & dermis Focal epidermal vacuolization has been observed in biopsy specimens immediately after laser exposure with energy density 6J/cm(2). As energy densities increased from 6J/cm(2) to 10J/cm(2), histopathological changes got worsened with appearance of vesicles. subepi dermal seperations and epidermal necrosis. 2. Vascular damages of dermis Multiple foci of agglutinated RBC, fibrin and platelet thrombi within the dermal blood vessels have been observed in biopsy specimens immediately after laser exposure. There was a pattern of "acute vasculitis" in the upper dermis and a prominent perivascular neutrophilic responses in the mid-dermis 2 days after laser exposure. Dermal vessels with smaller lumen and granulation tissue have been observed in biopy specimens 7 days after laser exposure. In summary, penetration depth of laser beam and nonvascular epidermal and dermal damages were directly proportional ot the energy density of the laser. But 7 days after laser exposure, epidermis and dermis showed normal appearance without detectable scarring. This study suggested that Candela SPTL-1 laser is safe and has no scar formation on the treatment of PWSs.
Biopsy ; Blood Platelets ; Blood Vessels ; Cicatrix ; Dermis ; Epidermis ; Fibrin ; Granulation Tissue ; Humans ; Neck ; Necrosis ; Neutrophils ; Port-Wine Stain* ; Vascular Malformations

No abstract available.

No abstract available.
Dermatitis, Atopic*

No abstract available.
Acute Coronary Syndrome*