2.Intestinal Spargnanosis Presenting as an Inflammatory Mass: A case report.
Weon Seo PARK ; Seung Sook LEE ; Yong Il KIM ; Seon Hee KIM
Korean Journal of Pathology 1992;26(4):414-416
A 39-year-old male patient presented with chronic abdominal pain and intermittent diarrhea for 8 months. Colon study showed an annular stricture at the ileocecal value. He underwent ileocecectomy with clinica impression of intestinal tuberculosis. The resected intestinal wall along the lieocecal junction demonstrated a localized, annular constriction and intramural nodular inflammatory growth in which were clusters of multiple microabscesses as well as acute and chronic inflammatory cell infiltration including eosinophils and fibrosis. Encountered were a few resolving phase of parasitic granulomatous tunnels in which fragments of degenerated sparganum with foreign body reaction were found in one focus. He had history of ingesting uncooked frogs 2 years ago. The above case suggests that differential diagnosis of inflammatory tumorous lesions in the intestine should include sparganosis in Korea.
Male
;
Humans
;
Diagnosis, Differential
3.A case report of primary aortogastric fistula sustained from traffic accident.
Yong Sik KIM ; Young Gwan KO ; Choong YOON ; Weon Kon KIM ; Hee Du KYUNG
Journal of the Korean Society of Emergency Medicine 1991;2(1):107-111
No abstract available.
Accidents, Traffic*
;
Fistula*
4.The Effects of Castration and Sex Hormone Administration on Lactic and Malic Dehydrogenase Activities in the Testis and the Prostate Tissues of Male Rabbits.
Korean Journal of Urology 1967;8(1):1-8
As a process to study the mechanism of steroid hormones at the molecular level,the activities of lactic dehydrogenase (L.D.) and malic dehydrogenase (M.D.),NAD-linked transhydrogenases, were measured in the testis and the prostate. Ahundred male rabbits were divided into ten group as follows: Group 1: Control Group 2: Estrogen (6,000 units) injected Group 3: Androgen (1,200 unite)injected Group 4: Progesterone (1,200 units) injected Group 5: Hydrocortisone(30 mg) injected Group 6: DOCA (6 mg) injected Group 7: Castration control Group8: Castration and estrogen (6, OOO units) injected Group 9: Castration and androgen (1,200 units) injected Group 10: Castration and progesterone (1,200units) injected Changes in the activities of lactic dehydrogenase and malic dehydrogenase in theorganic tissues by exogenous steroid hormones were carefullyobserved. The lactic dehydrogenase activities were measured by the method of Wroblewski and La Due, and malic dehydrogenase activities by the Bodansky's modification of Porter's method. The results are as follows: 1) The control valueof L.D. activities in the testicular tissue of normal rabbits proved to be 89,400units per ram. The L.D. activities showed an increase up to 110.4 per cent in theestrogen injected group, 179.3 per cent in the androgen injected group and 147.0 per cent in the progesterone injected group, while the administration of hydrocortisone and DOCA decreased the value down to 85.2 per cent and 81.5 per cent, respectively. 2) The control value of M.D. activities in the testicular tissue of the normal rabbits was 23,600 units per gram. The M.D. activities showed an increase upto 111.4 per cent in the estrogen injected group. 191.1 per cent in the androgen injected group, and 156.8 per cent in the progesterone injected group, while the administration of hydrocortisone and DOCA decreased the value down to 85.2 per cent and 81.5 per cent, respectively. 3) In the prostate tissues of non-castrated rabbits, the L.D. activities were estimated normally to be 48,100 units per gram. The administration of sex hormone resulted in raising the activities upto 101.8 per cent in the estrogen injected group, 196.9 per cent in the androgen injected group and 153.9 per cent in the progesterone injected group. But the administration of hydrocortisone and DOCA decreased the value down to 92.5 per cent and 97.1 per cent, respectively. 4) In the prostate tissue of non-castrated rabbits, the control value of M.D. activities proved to be 14,600 unite per gram. The M.D. activities showed an increase upto 117.8 per cent in the estrogen injected group, 206.8 per cent in the androgen injected group and, 176.7 per cent in the progesterone injected group, while the administration of hydrocortisone and DOCA decreased the value down to 81.9 per cent and 95.2 per cent, respectively. 5) The prostatic L.D. activities were decreased to half the normal two weeks after castration. The administration of sex hormones (i.e., estrogen, androgen and progesterone) acted inclusively upon elevating the level f activities. Androgen, in general, was the most effective to restore the activity to the level of pre-castrated state. 6) The prostatic M.D. activities were also decreased to half the normal two weeks after castration. The administration of sex hormones acted inclusively upon elevating the level ofthe activities. Androgen had a remarkable effect in elevating the M.D. activities, which showed twice the precastration level. In this study, it is concluded that L.D. and M.D. activities are present in the testis and the prostate. They are induced and activated by the administration of sex hormones, of which androgen has the most remarkable effect, and estrogen and progesteronehave less effect, while hydrocortisone and DOCA are ineffective in some cases orinhibitory in others.
Castration*
;
Desoxycorticosterone Acetate
;
Estrogens
;
Gonadal Steroid Hormones
;
Humans
;
Hydrocortisone
;
Malate Dehydrogenase*
;
Male*
;
Oxidoreductases
;
Progesterone
;
Prostate*
;
Rabbits*
;
Testis*
5.Mature Cystic Teratoma of the Fallopian Tube: A case report.
Kye Weon KWON ; Jong Yup BAE ; Hee Jung AHN ; Yoon Jung AHN ; Bok Soo KIM
Korean Journal of Pathology 1996;30(10):951-953
Teratomas of the fallopian tube are extremely rare, and only about 50 cases have reported in the world literature. Most cases of mature cystic tubal teratoma are asymptomatic and are discovered as an incidental finding on physical or radiologic examination, or at the time of laparatomy. We report a case of mature cystic teratoma of the right fallopian tube which was discovered during pelvic ultrasonogram for antenatal care in a 28 year old woman. Right salpingectomy was performed during cesarean section for cephalo-pelvic distortion at IUP 39 weeks. Gross examination of the right fallopian tube reveals a distended fallopian tube, measuring 8cm in length and 2cm in diameter. On section, it is filled with several small pedunculated nodules and cysts containing sebaceous materials. Microscopically the tumor was seen in continuity with the lining epithelium of mucosal folds. The majority of the tumor was composed of well differentiated mature elements of three germ layers with skin and skin appendages, mature brain tissue, bone, breast tissue, intestinal mucosa and bronchial epithelium.
Female
;
Humans
;
Cysts
6.Screening of Urine Culture Specimens by Gram Stain, Urinalysis and Urine Microscopic Examinations.
Chul Hun CHANG ; Tae Hee PARK ; Yoon Seong JEONG ; Hyung Hoi KIM ; Weon Joo HWANG
Korean Journal of Clinical Microbiology 2000;3(1):53-56
BACKGROUND: The purpose of this study was to discover ways to screen urine culture specimens through Gram stains, urine stick analyses and microscopic examinations for the laboratory cost saving. METHODS: One hundred and fifty-eight urine specimens for culture were included. Fifty uL of urine were inoculated onto one well each of 10-well slide, dried on the hot plate, and Gram-stained. The results combined with routine urinalyses including urine nitrite and leukocyte esterase, and pyuria, were compared with the routine culture results. RESULTS: The screening of bacteriuria by Gram stains, urinalyses and microscopic examinations revealed the high sensitivity (91.9%) and negative predictive value(95.5%) with cost saving of 41.8% of inoculating media. Not considering the Gram stains, the screening revealed 83.8% sensitivity and 92.5% negative predictive value, even if the cost saving of inoculating media were as high as 50.1%. CONCLUSION: It was demonstrated that it was sensitive and economic and produced rapid preliminary results to screen bacteriuria by the Gram stains combined with urinalyses and microscopic examinations.
Bacteriuria
;
Coloring Agents
;
Cost Savings
;
Leukocytes
;
Mass Screening*
;
Pyuria
;
Urinalysis*
7.A Comparison of Stamey with Raz Operation for the Treatment of Stress Urinary Incontinence.
Weon Kyo SEO ; Choal Hee PARK ; Chun Il KIM
Korean Journal of Urology 1996;37(3):346-351
To compare the efficacy of Stamey with that of Raz procedure in the correction of stress urinary incontinence, we studied retrospectively 43 patients who underwent either procedure at our institution between January, 1989 and June, 1994. Of 43 Patients were 23 underwent Stamey and 20 underwent Raz procedures. Patient's characteristics of the 2 groups were similar, but mean operative time was 107 minutes in Stamey and 76 minutes in Raz procedure(P<0.05), a care rate was obtained postoperatively in 65y. of the patient in Stamey and in 85% in Raz procedure(P<0.05). Postoperative complications were similar in 13.5% of the patients in Stamey and in 12.5% in Raz procedure. Although most predictive factors were not associated with cure or failure in our series, the postoperative cure rate was significantly higher in the group with urinary retention of more than a week. It is thought that Raz procedure is more safe and accurate than Stamey procedure by its shorter operation time and higher success rate(P<0.05). although patient's satisfaction with postoperative morbidity is similar between Stamey and Raz procedure.
Humans
;
Operative Time
;
Postoperative Complications
;
Retrospective Studies
;
Urinary Incontinence*
;
Urinary Retention
9.Long-term Followup of Clean Intermittent Catheterization in Patients with Neurogenic Bladder.
Weon Kyo SEO ; Choal Hee PARK ; Chun Il KIM ; Kwang Sae KIM
Korean Journal of Urology 1995;36(6):645-650
From 1986 to 1993, we analyzed experiences in clean intermittent catheterization(CIC) of 62 patients with neurogenic bladder who were closely follow up for averaging 25months. Initial urodynamic study revealed hyperreflexic bladder in 21patients: 11 with detrusor sphincter dyssynergia. Areflexic bladder was found in 41patients: l5 with low compliance. Although positive urine culture were relatively frequent(61%), febrile urinary tract infections were rare(3%) and upper urinary tract function was stable. Other complications of CIC(29%) were burning sensation, resist on urethral catheter, epididymitis, scrotal abscess, bladder stone, etc. Although minor complications are not rare, we can conclude that preservation of renal function and improvement of urinary incontinence can achieved with intermittent catheterization and that patient must be well motivated and cooperative and be able to use their hands for continuation of CIC.
Abscess
;
Ataxia
;
Burns
;
Catheterization
;
Catheters
;
Compliance
;
Epididymitis
;
Follow-Up Studies*
;
Hand
;
Humans
;
Intermittent Urethral Catheterization*
;
Male
;
Sensation
;
Urinary Bladder
;
Urinary Bladder Calculi
;
Urinary Bladder, Neurogenic*
;
Urinary Catheters
;
Urinary Incontinence
;
Urinary Tract
;
Urinary Tract Infections
;
Urodynamics
10.Prediction of response in chemotherapy and molecular targeted therapy using pharmacogenetics and positron emission tomography.
Korean Journal of Obstetrics and Gynecology 2008;51(11):1221-1238
Standard treatment of cancer is composed of surgery, radiation therapy and chemotherapy. Although the standard treatment has been available till now, there has been no marked decrease in the incidence of cancer and cancer-related death till now. This fact demonstrates the limitation of the standard treatment for overcoming cancer. Predictive oncology is defined as the method that can identify the difference in drug response and toxicity before treatment, which has developed in the fields of chemotherapy and molecular targeted therapy. Especially, pharmacogenetics and positron emission tomography (PET) are important in predictive oncology. The former shows that drug metabolism affecting response and toxicity may be affected by genetic predisposition, especially genetic polymorphism. The latter evaluates response by use of PET after 1-2 cycle administration of drug and differentiates responders from non-responders among patients with breast, esophagus, lung and rectal cancers. In the near future, individualized treatment that is more effective than the standard treatment will be developed through predictive oncology and be applied in cancer patients for maximizing drug response and minimizing toxicities.
Breast
;
Electrons
;
Esophagus
;
Genetic Predisposition to Disease
;
Humans
;
Incidence
;
Lung
;
Molecular Targeted Therapy
;
Pharmacogenetics
;
Polymorphism, Genetic
;
Positron-Emission Tomography
;
Rectal Neoplasms