No abstract available.
Dizziness* ; Vertigo*

Anti-Bacterial Agents ; Bacterial Infections ; Dental Caries ; Drainage ; Head ; Humans ; Incidence ; Ludwig's Angina ; Neck ; Penicillins ; Periodontal Diseases ; Suppuration ; Surgery, Oral ; Tracheostomy

No abstract available.
Animals ; Ethanol* ; Interleukin-2* ; Interleukin-6* ; Rats*

BACKGROUND: Respiratory depression with high dose of propofol during induction is one of the major complications. We studied the effects of midazolam as premedicant on frequency and duration of apnea and frequency of loss of consciousness in relation to single dose of propofol. METHODS: We selected 194 adult patients who had clear consciousness and no depression of respiration. We allocated patients randomly to control group and midazolam group. In midazolam group, we injected 0.06mg/kg of midazolam intravenously 10min before induction, and in control group, we did nothing. Under mask oxygenation with 100% oxygen, we administered a bolus of propofol (1, 1.5, 2 mg/kg to subgroup 1, 2, 3 respectively) intravenously. The change of respiration and loss of consciousness were observed. RESULTS: The frequency and duration of apnea increased with the dose of propofol in both control and midazolam group. But there were no difference between groups except frequency of apnea with 1.5 mg/kg of propofol. In control group, frequency of loss of consciousness increased with the increasing dose of propofol. But in midazolam group, nearly all the patients was slept without difference by the dose. CONCLUSIONS: Premedication with midazolam reduce the sleeping dose of propofol to induce anesthesia, so the frequency and duration of apnea which is caused by high dose of propofol can be decreased.
Adult ; Anesthesia ; Apnea* ; Consciousness ; Depression ; Humans ; Masks ; Midazolam* ; Oxygen ; Premedication ; Propofol* ; Respiration ; Respiratory Insufficiency ; Unconsciousness*

BACKGROUND: The HLA system is known to be the most polymorphic genetic system in human and there are characteristic racial differences in the distribution of HLA antigens, alleles, and haplotypes. This study was performed to examine the frequency of HLA antigens, alleles and haplotypes in Koreans. METHODS: Two thousand healthy Koreans registered for unrelated bone marrow donors were subject to the study. HLA-A, B and C antigens were typed by the serological method, and HLA-DR DNA typing (low resolution) was done by PCR and reverse hybridization. HLA allele and haplotype frequencies and linkage disequilibrium values were calculated by the maximun likelihood method using the computer program of the 11th International Histocompatibility Workshop. RESULTS: HLA antigens identified in 2000 Koreans were 14 in A locus, 33 in B locus, 8 in C locus and 12 in DR locus. Alleles showing frequencies of more than 10% in decreasing order of frequency In each HLA locus were A2, A24, A33, All, B44, B62; CBL, Cw3, Cwl, Cw7, DR4, DR2, DRl3, DR8, and DR9. Among A-B, C-B, B-DR 2-locus haplotypes, A33-B44, A30-B13, Al-B37, Cwl-B54, Cw4-B62, B7-DR1, B37-DR10 showed strong positive linkage disequilibrium (Chi-square > 1000). The most common A-B-DR haplotypes in Koreans occurring at frequency of more than 2% were A33-B44-DRl3 (4.8%), A33-B58-DRl3 (3.2%), A33-B44-DR7 (2.6%), All-B62-DR4 (2.3%), A24-B7-DR1 (2.3%), and A30-Bl3-DR7 (2.1%) Comparison of the distribution of A-B-DR haplotypes among east Asian populations reveals that Koreans are most close to Japanese, but show higher degree of polymorphism in the distribution of HLA haplotypes compared to Japanese. CONCLUSIONS: The results obtained in this study can be used as basic data for Koreans in the fields of organ transplantation, disease association studies and anthropologic studies.
Alleles ; Asian Continental Ancestry Group ; Bone Marrow ; DNA Fingerprinting ; Education ; Haplotypes* ; Histocompatibility ; HLA Antigens* ; HLA-A Antigens ; HLA-DR Antigens ; Humans ; Linkage Disequilibrium ; Organ Transplantation ; Polymerase Chain Reaction ; Tissue Donors ; Transplants

Osteoblastoma is a rare benign bone tumor and is characterized hitologically by an abundant number of osteoblasts and by the presence of s large amount of osteoid tissue in a highly vascular matrix. The lesion is frequently encountered in children and adolescents with most of the cases occuring between the ages of 10 and 25 years. There is significant sex prevalence (M.: F.=2: 1). Up to now there has been few reports of a benign osteoblastoma occuring in the cervical spine. This report describes a boy of a benign osteoblastoma which involved the cervical vertebral arch and spinous process, presenting with pain and limitation of motion. He was given en-bloc resection of tumor mass and confirmed by histological examination. Postoperation result was good and he goes school without any problem in about 12 months of follow up.
Adolescent ; Child ; Follow-Up Studies ; Humans ; Male ; Osteoblastoma ; Osteoblasts ; Prevalence ; Spine

No abstract available.
Arthritis, Rheumatoid* ; Humans ; Hyperplasia* ; NF-kappa B*

No abstract available.
Female ; Humans ; Pregnancy ; Pregnancy Trimester, Second*

BACKGROUND: After the resurgence of endemic malaria case in 1993, the number of malaria cases is increasing in succeeding years and most of patients were soldiers who served in the northern parts of Kyeonggi-do and Kangwon-do. Because group donations of blood from soldiers are frequent in these area, it is possible that donated blood from these area cause malaria. So we examined blood donation history of malaria patients to know their donation behavior. METHODS: The subject was 1,671 malaria patients who were diagnosed in 1997 and referred to blood transfusion research institute and their past donation history, time and frequency of donation were examined. The database consisted of malaria patients and blood donors who are known to be related with transfusion-transmitted malaria has been retrieved at each red cross blood center for every blood donors. The results were analyzed from January to December, 1998. RESULTS: About 60% (1,017) of 1,691 malaria patients in 1997 had donated their blood before diagnosis. The number of one time donation was 268; two time 289; more than three time was 460. Two hundred thirty six donors were checked by malaria registry file. In 236 donors, 92 cases were diagnosed with malaria, 96 cases were suspected to have malaria, 48 cases were namesakes. Conclusion: Because some malaria patients donate their blood after their diagnosis, it would be necessary to operate 'the computerized retrieving programme'to detect their donation after the diagnosis. Also, an education for malaria patients for their risk of transmitting malaria and strict history taking from donors for malaria will be required.
Academies and Institutes ; Blood Donors* ; Blood Transfusion ; Diagnosis ; Education ; Gangwon-do ; Gyeonggi-do ; Humans ; Malaria* ; Military Personnel ; Red Cross ; Tissue Donors

PURPOSE: The authors investigated the clinical significance of the C-reactive protein(CRP) in recurrence, metastasis and prognostic factors of renal cell carcinoma(RCC). MATERIALS AND METHODS: From January 1994 to April 1998, a total of 48 patients (confirmed as the RCC by pathology after radical nephrectomy) underwent a study that made a correlation between the CRP and stage, tumor size, grade, cell type, patient`s age and sex. The CRP was measured preoperatively and postoperatively at an interval of 3 months by the rate nephelometry (quantitatively). RESULTS: The mean of preoperative CRP(mg/dL) were 1.29 at stageI, 0.50 at II, 3.67 at III, 0.50 at IV. The mean of preoperative CRP in tumor size were 1.07 at<5cm, 1.62 at 5-10cm, 1.60 at >10cm. With regard to grade, the mean of preoperative CRP were 0.50 at grade I, 0.62 at II, 0.86 at III, 4.04 at IV, but there was no statistical significance(p=0.24). The mean of preoperative CRP were 1.44 at clear cell type, 0.76 at granular cell type, 0.50 at mixed type. With regard to age, the mean of preoperative CRP were 1.15 in the 4th decade, 0.98 in the 5th, 1.93 in the 6th, 0.97 in the 7th and 0.50 in the 8th decade. The mean of preoperative CRP were 1.18 in men, 1.52 in women. There were 5 patients who had distant metastasis during the follow up interval. The preoperative average of the CRP in this group was 0.50 and 0.74 at the time of distant metastasis; however, it was not statistically significant(p=0.07). CONCLUSIONS: The CRP was not a significant prognostic factor in the RCC as compared with the stage, grade, tumor size, cell type, age and sex.
C-Reactive Protein* ; Carcinoma, Renal Cell* ; Cell Size ; Female ; Follow-Up Studies ; Humans ; Male ; Neoplasm Metastasis ; Nephelometry and Turbidimetry ; Pathology ; Recurrence