A case of pigmented villonodular synovitis developed in the right ankle joint is reported. The patient was a 25 years old house wife who had complained marked swelling and tenderness over the anterolateral aspect of the right ankle for 2 years. Roentgenological studies showed marked swelling of the ankle joint and erosion of the neck of the talus. Synovectomy of the affected joint was performed. The tumor mass, measuring about 7cm×5cm×2cm in size, was yellowish brown in colour, elastic and soft in consistency, and contained several well encapsulated nodules.
Ankle ; Ankle Joint ; Humans ; Joints ; Neck ; Spouses ; Synovitis, Pigmented Villonodular ; Talus

Systemic lupus erythematosus (SLE) is a multisystemic disease that can involve the gastrointestinal tract, liver, and biliary system. Symptomatic pancreatic involvement, however, has rarely been reported. It may be part of the primary disease process, such as vasculitic or autoimmune etiology, or associated with drug therapy, in particular corticosteroid. We report here a lupus patient who developed severe pancreatitis within 30 hours of initiation of corticosteroid therapy; we also discuss the relation between pancreatitis and systemic lupus erythematosus.
Biliary Tract ; Drug Therapy ; Gastrointestinal Tract ; Humans ; Liver ; Lupus Erythematosus, Systemic* ; Pancreatitis*

The intravenous administration of midazolam is widely used as sedative premedication for upper gastrointestinal endoscopy. We performed a study to evaluate the effectiveness and safety of midazoiam as premedication for upper gastrointestinal endoscopy. Between June 1995 and October 1995, 112 patients of diagnostic esophago-gastroduodenoseopy were enrolled in the study. The patients were recieved a bolus midazolam 0.~03mg/kg or placebo, followed by typical anesthesia. The blood pressure, pulse and oximeter values were monitored. The systolic blood pressure and heart rate were increased during endoscopy in compared with before premedication, and normalized immediately. There was no significant change of arterial oxygen saturation. Midazolam induced amnesia completely in 49.2% and partially in 27.2%, and all patients were recovered completely in 1 hour. The tolerance score is higher in the midazolam group as compared with the placebo group(p<0.05), and midazolam group would accept the same sedation for repeated endoscopies(p<0.01). We conclude that midazolam has beneficial effects as premedication for upper gastrointastinal endoscopy without significant altteration in cardiopulmonary parameters. This suggest that midazolam may be used more frequently as premedication, especially in the cases of repeated endoscopy.
Administration, Intravenous ; Amnesia ; Anesthesia ; Blood Pressure ; Endoscopy ; Endoscopy, Digestive System ; Endoscopy, Gastrointestinal* ; Heart Rate ; Humans ; Midazolam* ; Oxygen ; Premedication*

No abstract available.
Paragonimiasis*

OBJECTIVE: To evaluate the basophil histamine releasability in response to IgE- and non- IgE-mediated stimuli in children with atopic asthma. Met: Basophil histamine releasability was measured in Dermatophagoides farinae (D. farinae)-sensitive atopic asthmatics, D.farinae-sensitive healthy atopics, non-atopic asthmatics, and healthy non-atopics. Basophils were stimulated with D.farinae, goat antihuman IgE antibody, formyl-Met-Leu-Phe(fMLP), and Calcium ionophore A23187. Histamine was measured by automated fluorometric technique. RESULTS: Sponianeous histamine release was higher in atopic asthmatics compared to healthy non-atopics. Histamine release by D.farinae and by anti-IgE antibody was higher in atopic asthmatics compared to the other groups. There was no difference in histamine release by fMLP among all groups. Histamine release by Calcium ionophore was higher in healthy atopics and non-atopic asthmatics compared to healthy non-atopics. The atopics showed correlation between histamine release by D.farinae, by anti-IgE antibody and total serum IgE levels. CONCLUSIONS: Spontaneous and IgE-mediated histamine release were related to the presence of both atopy and asthma, whereas non-IgE mediated histamine release was different depending on the stimuli.
Asthma* ; Basophils* ; Calcimycin ; Calcium ; Child* ; Dermatophagoides farinae ; Goats ; Histamine Release ; Histamine* ; Humans ; Immunoglobulin E

STATEMENT OF PROBLEM: The Cement as well as restoration required esthetics for making natural color restoration. PURPOSE: The purpose of this research is to evaluate color stability of restoration intermediated by resin cement which is used for cementation of all ceramic crown. MATERIAL AND METHOD: After making Empress 2 ingot into the size of 10mm x 10mm x 1mm according to indication, it glazed and made 48 Empress 2 blocks. Three kinds of resin cement(Rely-X, Variolink 2, Choice) having same shade cemented between Empress 2 blocks and Ivory shade tiles and made 48 specimens in the thickness of 30 micrometer and 80 micrometer. After measureing color difference using spectorphotomenter, the result of this study were as follows. RESULTS: The color difference of resin cement used in experiment increased in the order Rely-X, Variolink 2. As the thickness of cement increases, the color difference of all kinds of cement found statistically sifnificant difference but, this result is clinically acceptable. CONCLUSION: More resarch would have to be done in order to decrease the color difference as cement's thickness.
Cementation ; Ceramics* ; Crowns* ; Esthetics ; Resin Cements*

We investigate the clinical characteristics of Sjogren's syndrome (SS). METHODS: We. retrospectively reviewed 59 patients with SS in the period from January 19: To 86 to January 1997. European Epidemiology Center criteria was used to diagnose SS. OBJECTIVES AND RESULTS: Thirty-one primary SS and 28 secondary SS patients were included in this study. There were 57 females and 2 males, the mean age was 45. 2+12.3 years (24 to 70 years). Patients with secondary SS were associated with rheumatoid arthritis(n=10), systemic lupus erythematosus(n=7), scleroderma(n=5), mixed connective tissue disease(n=3), and myositis(n=3). The common presenting symptoms were dry mouth in 92% and dry eyes in 90% of patients. Other symptom and signs included fatigue(27%), lymphadenopathy(22%) and parotid gland swelling (10%). The commonly presented autoantibodies were antinuclear antibody(83%) and rheumatoid factor(57%). Anti-Ro was positive in 49%(25/51) and anti-La in 37%(19/51). Anti-La positivity was significantly higher in primary SS(52%) compared to secondary SS(21%) (p<0.05). Schirmer test was positive in 98% (44/45), salivary radioscintigraphy in 74%(25/34), and lower lip biopsy in 47%(16/34). Extraglandular manifestations, such as Raynaud's phenomenon, vasculitis, glomerulonephritis, vaginal dryness, renal tubular acidosis, and primary biliary cirrhosis, were more frequently presented in primary SS compared to secondary SS (p<0. 05). CONCLUSION: The sex, age, and clinical manifestation of primary SS were similar with secondary SS, but extraglandular manifestations and anti-La antibody positivity were more frequent in primary SS.
Acidosis, Renal Tubular ; Autoantibodies ; Biopsy ; Connective Tissue ; Diagnostic Tests, Routine ; Epidemiology ; Female ; Glomerulonephritis ; Humans ; Lip ; Liver Cirrhosis, Biliary ; Male ; Mouth ; Parotid Gland ; Retrospective Studies ; Sjogren's Syndrome* ; Vasculitis

No abstract available.
Cyclosporine* ; Dermatomyositis*

BACKGROUND: In pregnancy, paternal human leukocyte antigen (HLA) that the fetus possesses can induce the development of cytotoxic HLA antibodies in the pregnant women. We investigated the frequency and the characteristics of HLA antibodies during the pregnancy in Koreans. METHODS: Sera from 192 pregnant women (46 in the 1st trimester, 120 in the 2nd and 26 in the 3rd trimester) were tested for the presence of HLA antibody. Home made lymphocyte panel from 36 volunteers whose HLA-A, B and C antigens had been already identified 3nd formerly frozen in a liquid nitrogen tank were dispensed in duplicate into 72-well microplates and used as testing trays Test sera of one pregnant women with one negative control serum were dispensed in each plate and the plates were tested by microlymphocytotoxic method using anti-human immunoglobulin. The results were observed under fluorescence microscope and PRA (panel reactive antibody) values were determined by the percentage of wells showing positive reactions. HLA antibody specificities were identified by analysis of reaction characteristics. RESULTS: Among the 192 sera, 22 (11.5%) showed positive PRA value (PRA > 0%) in HLA antibody screening tests, in which 20 were less than 50% and 2 were more than 50% of PRA value. Two of the 46 subjects (4.3%) in the 1st trimester, 15 of the 120 (12.5%) in the 2nd and 5 of the 26 (19 2%) in the 3rd trimester were positive for HLA antibody. Among the 22 positive sera , specificities of HLA antibodies were identified in 14 (64%) sera: 8 sera had HLA antibody against single private HLA antigen. 5 had HLA antibodies against two or more antigens. and 1 sera showed anti-Bw4 antibody. CONCLUSION: In 192 pregnant women, 22 (11.5%) had HLA-A, B antibodies and they showed higher frequencies with the progress of pregnancy. Most of the pregnant women who were positive for HLA antibodies showed PRA value less than 50%. HLA antibody specificities were identified in 14 out of 22 positive sera (64%).
Antibodies* ; Antibody Specificity ; Female ; Fetus ; Fluorescence ; HLA-A Antigens* ; Humans ; Immunoglobulins ; Leukocytes ; Lymphocytes ; Mass Screening ; Nitrogen ; Pregnancy ; Pregnant Women* ; Volunteers

Pituitary apoplexy is defined as a complex series of clinical events occurring as a consequence of the fulminant expansion of the pituitary tumor by infarction, hemorrhage, or hemorrhagic infarction of the tumor and the adjacent pituitary tissue. It is one of the entities which need neurosurgical emergency care. Its incidence was, however, reported variously in many literatures due to different diagnostic criteria. We reviewed 150 histologically proven pituitary adenoma cases, operated from January 1980 to September 1986, to select 30 cases which showed clinical or operative findings compatible with pitultary apoplexy('pituitary apoplexy in a broad sense'). Authors analyzed their incidence, presidposing factor, clinical feature, diagnosis and treatment, especially in those who showed major attack with evident enurologic deficits('pituitary apoplexy in a strict sense'). The conclusions are as follows; 1) Among the 150 cases of pituitary tumor, 30 cases (20.0%) were diagnosed as pituitary apoplexy in a broad sense. Eleven cases (7.3%) out of them showed major attack. 2) The symptoms and signs of the 11 cases with major attack were sudden headache(11 cases), visual impairment (9 cases), cavernous sinus compression signs (7 cases), nausea and vomiting (6 cases), depressed consciouness (4 cases), and meningismus (3 cases). 3) In the clinical diagnosis of pituitary apoplexy, findings of plain skull radiologic view were very helpful. 4) With the medical treatment and surgery, good results were achieved in all cases except one patient showing visual impairment. 5) As the method of surgical treatment, the transsphenoidal approach is highly recommended.
Cavernous Sinus ; Diagnosis* ; Emergency Medical Services ; Hemorrhage ; Humans ; Incidence ; Infarction ; Meningism ; Nausea ; Pituitary Apoplexy* ; Pituitary Neoplasms ; Skull ; Stroke ; Vision Disorders ; Vomiting