1.Relationship between placental infarct and umbilical venous erythropoietin and gas values.
Korean Journal of Obstetrics and Gynecology 2000;43(10):1744-1749
No abstract available.
Erythropoietin*
2.C-reactive protein in preterm labor : Clinical significance and placental histology.
Korean Journal of Obstetrics and Gynecology 1993;36(7):916-927
No abstract available.
C-Reactive Protein*
;
Female
;
Obstetric Labor, Premature*
;
Pregnancy
3.Melanosis Coli: Relation to Apoptosis in Pathogenesis.
Sun Hee SUNG ; Hea Soo KOO ; Woon Sup HAN
Korean Journal of Pathology 1996;30(7):570-575
Melanosis coli is characterized by a dark brownish discoloration of the colonic mucosa. Its pathogenesis is still unknown. Recently it was proposed that the apoptosis of mucosal epithelium due to habitual use of laxatives play an important role for induction of melanosis coli. We studied clinicopathologic aspects of 12 cases of melanosis coli and analysed the histochemical and immunohistochemical characteristics of them. Results are as follows. : Mean patient's age was 53.5, and the male:female ratio was 4:8. Nine patients had a history of constipation, and all of these had administrated various kinds of laxatives. The severity of discoloration was correlated with the duration of constipation and age. There was no difference of anatomical distribution in colon. Other remarkable mucosal lesions were not accompanied. On pathologic examination, all cases showed frequent yellow-brown pigment laden cells in lamina propria. These pigments were positive for periodic acid Schiff stains, Fontana Masson stains, and Victoria blue stains, however they were negative for prussian blue stain. On immunohistochemical stainings pigmented cells were positive for CD68, and negative for S-100 protein and neuron specific enolase. These results indicate that they are macrophages. On ultrastructural examination pigmented cytoplasms were filled with variable sized electron dense granules including irregulary round deformed membranous structures, lipid vacuoles. Apoptosis of mucosal epithelium was noted in 5 cases. These findings suggest that apoptosis is the significant pathologic process in the progression of some cases of melanosis coli.
Female
;
Male
;
Humans
4.A Case of Treacher Collins Syndrome.
Hee Shang YOUN ; Koo Soo KIM ; Hyung Ro MOON
Journal of the Korean Pediatric Society 1984;27(2):207-212
No abstract available.
Mandibulofacial Dysostosis*
5.Agenesis of corpus callosum-two cases report.
Soo Young KWEON ; Jeoung Wean SEO ; Gyung Hee KIM ; Eun Chul CHUNG ; Hea Soo KOO
Journal of the Korean Pediatric Society 1992;35(1):113-121
No abstract available.
Agenesis of Corpus Callosum
6.Correlation Between the Frequency of Apoptotic Bodies and Gleason Scores in Prostatic Cancer.
Hee Soo YOON ; Ho Jung KIM ; Hea Soo KOO ; Ok Kyung KIM ; Sung Sook KIM
Korean Journal of Pathology 1997;31(5):462-469
Apoptosis (or programmed cell death) is defined by morphologic changes induced by a spectrum of physical and chemical agents. resulting in non-pathologic cell loss, which is relevant to a range of biological processes, including differentiation, development, maturation, and injury of cells as well as immunologic function. In this study, we examined the frequency of apoptotic bodies and mitoses (apoptotic and mitotic indices) in the tissue samples of 35 patients of prostatic carcinoma, which were grouped according to the Gleason scores, and 5 cases of benign prostatic hyperplasia. The indices were determined as the numbers of apoptotic and mitotic bodies per 100 tumor cells in hematoxylin eosin stained section. The apoptotic bodies were confirmed by the in situ nick end labelling method. The apoptotic and mitotic indices were observed more frequently in prostatic carcinoma than the benign hyperplastic prostatic tissues with a positive correlation between the frequency of apoptotic bodies and Gleason scores in prostatic cancer. In conclusion, an increased programmed cell death was correlated with the increasing malignant potential (higher Gleason scores) in prostatic cancer.
Apoptosis
;
Biological Processes
;
Cell Death
;
Eosine Yellowish-(YS)
;
Hematoxylin
;
Humans
;
In Situ Nick-End Labeling
;
Mitosis
;
Mitotic Index
;
Neoplasm Grading
;
Prostatic Hyperplasia
;
Prostatic Neoplasms*
7.Expression of Sialosyl Tn Mucin Antigen in Gastric Adenocarcinoma and Its Relationship with Prognostic Factors.
Sun Hee CHANG ; Ho Jung KIM ; Sun Hee SUNG ; Hea Soo KOO ; Woon Sub HAN
Korean Journal of Pathology 1999;33(9):695-701
Sialosyl Tn mucin antigen (STn) is a carbohydrate antigen of tumor associated mucin formed by the premature 2~6 sialation of N-acetylgalactosamine. STn has been expressed in several tumor types and showed prognostic significance in colonic carcinoma. The authors evaluated the expression of STn immunohistochemically and correlated its expression with clinicopathologic variables in 100 gastric cancers. In early gastric cancer, STn was expressed in 24 cases out of 50 cases (48%). In advanced gastric cancer, STn was expressed in 48 of 50 (96%). The difference in STn expression between advanced gastric cancer and early gastric cancer was statistically significant. The difference in STn expression between tumors with lymph node metastasis and those without lymph node metastasis, between tubular adenocarcinoma and signet ring cell carcinoma, and between intestinal type and diffuse type adenocarcinoma was statistically insignificant in early or advanced gastric adenocarcinoma. These results suggest that the STn expression plays a role in the tumor progression in both early and advanced gastric adenocarcinomas.
Adenocarcinoma*
;
Carcinoma, Signet Ring Cell
;
Colon
;
Lymph Nodes
;
Mucins*
;
Neoplasm Metastasis
;
Stomach
;
Stomach Neoplasms
8.Facial nerve decompression in Melkersson-rosenthal syndrome.
Seong Soo BAN ; Hee Yoon KOO ; Kwang Ik KO ; Hee Wan PARK ; Kwang Ryun KO
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(5):903-908
No abstract available.
Decompression*
;
Facial Nerve*
;
Melkersson-Rosenthal Syndrome*
9.Taxol-induced Pathological Findings in Rat Small Intestine.
Sun Hee CHANG ; Shi Nae LEE ; Hee Soo YOON ; Min Sun CHO ; Hea Soo KOO ; Woon Sup HAN
Korean Journal of Pathology 1997;31(12):1291-1296
Taxol is an active chemotherapeutic agent against a variety of solid tumors and a potentially useful drug for augmenting the cytotoxic action of radiotherapy against certain cancers. Taxol blocks cells in the mitotic phase of cell cycle. The aim of this study was to define the in vivo response of rapidly dividing cells of the small intestinal mucosa to taxol. We studied the numbers of apoptotic and mitotic cells and the expression of bcl-2 and p53 in rat jejunal crypt cells at 1, 2, 4, 8, 12, 16, and 24 hours and 3 and 5 days after intraperitoneal injection of taxol. Mitosis peaked at 2 and 4 hours and 12 and 16 hours. Apoptosis peaked at 16 hours and returned to normal after five days. The glands in crypts showed marked distortion with atypical lining cells after three days, which returned to normal at 5 days. bcl-2 expression was markedly decreased at 8 to 24 hours and subnormally recovered after three to five days. p53 showed no significant changes throughout. The histopathological changes in small intestine due to taxol were transient with complete recovery. bcl-2 expression was inversely corresponded to numbers of apoptosis. The changes were p53 independent. Further studies to understand the conditions that maximize the cell-cycle modulating effects of taxol cl-may greatly enhance its anti-tumor effectiveness.
Animals
;
Apoptosis
;
Cell Cycle
;
Injections, Intraperitoneal
;
Intestinal Mucosa
;
Intestine, Small*
;
Mitosis
;
Paclitaxel
;
Radiotherapy
;
Rats*
10.Accompanied Histopathologic Findings and Association of Serum beta-HCG Levels with Myosalpingeal Invasion in Ectopic Tubal Pregnancy.
Hye Jin PARK ; Ho Jung KIM ; Hea Soo KOO ; Sun Hee SUNG ; Won Sup HAN
Korean Journal of Pathology 1999;33(7):497-502
Most ectopic pregnancies occur in the fallopian tubes. There have been numerous theories to explain the occurrence of ectopic pregnancy in fallopian tubes. The most commonly held view is that the passage of the fertilized ovum through the fallopian tube is delayed or hindered by chronic inflammation and its sequelae. We designed a study to evaluate the details of histopathologic changes and the location of implantation and how they relate to the clinical history. 182 fallopian tube specimens from patients who had undergone total or partial salpingectomy were examined. A high incidence of non-specific inflammation of plicae and wall of tube (31.9%) and salpingitis isthmica nodosa (12.6%) were observed. Other associated findings included acute salpingitis, complex plicae or complex hyperplasia of tubal epithelium, fibrous adhesion with ovary, endometriosis, and calcification. History of previous ectopic tubal pregnancy was found in 8 cases. The cases with serum beta-HCG value above 2,500 I.U./L (group I, n=97) were more frequently noted in those exhibiting myosalpingeal invasion of trophoblast (67 cases) than in those without invasion (30 cases). Of the 182 tubal pregnancies, 117 (64.3%) cases were found in the ampulla and 47 (25.8%) cases in isthmic location. In 117 ampullary pregnancies, the products of conception were found intraluminally in 71 cases (60.7%), and extraluminally in 34 (29.1%) cases, of which the products of conception were found entirely extraluminal. The products of conception, found both within and outside the tubal lumen, were found in 12 cases (10.2%). Of 47 tubes with isthmic pregnancies, 33 cases were intraluminal (70.2%), 12 cases were extraluminal (25.5%), and two cases were mixed (4.3%). In conclusion, significant histopathologic abnormalities accompany a majority of ectopic tubal pregnancy, and myosalpingeal invasion of trophoblast is correlated with high serum beta-HCG. Thus, it is necessary to confirm not only the ectopic placental tissue but also the accompanying details of the other histopathologic findings or the pathologic evaluation of ectopic tubal pregnancy.
Endometriosis
;
Epithelium
;
Fallopian Tubes
;
Female
;
Fertilization
;
Humans
;
Hyperplasia
;
Incidence
;
Inflammation
;
Ovary
;
Pregnancy
;
Pregnancy, Ectopic
;
Pregnancy, Tubal*
;
Salpingectomy
;
Salpingitis
;
Trophoblasts
;
Zygote