Percutaneous aspiration needle biopsy of the intrathoracic disease is a safe, easy, and accurate diagnostic method. It usually causes mild pain or discomfort during the procedure. We had a patient who complained of severe sharp pain, well localized at the biopsy site of the target mass during CT-guided transthoracic aspiration biopsy. It was pathologically confirmed as an intrathoracic schwannoma after special staining. To our knowledge, there has been no published report of such a painful percutaneous needle biopsy in a patient with schwannoma in Korea. Two cases were reported in other radiologic journals. The severe sharp pain developed during the transthoracic aspiration needle biopsy is a reliable sign of neurogenic tumor, therefore the participating radiologist should recommend specific immumochemical stain for neurogenic tumor to pathologist.
Biopsy ; Biopsy, Needle* ; Humans ; Korea ; Needles* ; Neurilemmoma*

For evaluating the reproductive performances of GTD patients, we found 115 cases of GTD patients, 77 HM and 38 GTT, who became pregnant after the completion of treatments and follow-up period. The results of this study suggest subsequent pregnancies after the completion of treatments may promise normal reproductive outcomes regardless of the chemotherapy.
Drug Therapy ; Follow-Up Studies ; Gestational Trophoblastic Disease* ; Humans ; Pregnancy

PURPOSE: To determine the publication rate of abstracts presented at the scientific meetings of the Korean Radiological Society(KRS) and to compare the contents of publication articles and presentation abstracts. MATERIALS AND METHODS: Between 1992 and 1996 it was determined whether or not 2457 abstracts presented at meetings of the KRS were published in the Journal of the Society. Publications that matched presentations were identified, and the proportion of abstracts published was calculated. Differences in publication rates between spring and autumn meetings, and between scientific sessions(SS) and scientific exhibitions(SE) were examined. The elapsed time between presentation and publication was recorded. The contents ( authors, title, purpose, materials and methods, results, and conclusion) of abstracts presented at scientific meetings of the KRS were compared with those of articles published in the Journal of the KRS. RESULTS: We found that the mean proportion of abstracts published as articles was 25%. There was a significantly different publication rate between spring and autumn meetings, and between SS and SE. The mean time lapse between presentation and publication was 13.3 months. The mean number of authors was 4.8 in the case of abstracts and 5.8 in the case of articles. Of the 614 articles, 98 (16 %) showed no evidence of a change of first author. Articles were more likely to mention an additional coauthor( 81 % versus 66 % , p < 0.05) when the first author was a resident than when he or she was a staff member. The purpose and conclusion of the studies remained the same in a high percentage of cases (87% for purpose and 71% for conclusion). CONCLUSION: The fact that only 25% of the abstracts presented at scientific meetings of the KRS have been published is one that should be of concern to the investigators involved. It is important that studies undertaken should proceed to the publication stage. though it is recognized that the discrepany in this respect is probably due to factors which are not academic.
Humans ; Publications ; Research Personnel

PURPOSE: This paper is to evaluate radiological features of hypersensitivity pneumonitis, correlated with clinical and pathologic findings. MATERIALS AND METHODS: Patients consisted of 2 men and 3 women, aged 23-51 years old (average 41). Diagnosis was based on the presence of suggestive clinical and radiological findings (chest radiography, high resolutional CT, gallium scintigraphy), and lung biopsy showing characteristic histological features. RESULTS: All patients complained of exertional dyspnea and three patients experienced coughing. On the pulmonary function test, four patients revealed restrictive pattern and one patient was normal. Results of bronchoalveolar lavage, available in four patients, revealed lymphocytosis in three patients and normal finding in one patient. Chest radiographs showed ground glass opacity or diffuse nodular densities. On the HRCT, diffuse nodular opacity and ground glass opacity were seen in variable features. All 4 patients had diffuse increased uptake on the gallium scan. On lung biopsy, a combination of histologic findings showed cellular bronchiolitis, diffuse interstitial infiltrates and non-necrotizing granulomas, consistent with diagnosis of hypersensitivity pneumonitis. CONCLUSION: Hypersensitivity pneumonitis could be diagnosed with these radiological, clinical and pathological findings.
Alveolitis, Extrinsic Allergic* ; Biopsy ; Bronchiolitis ; Bronchoalveolar Lavage ; Cough ; Diagnosis ; Dyspnea ; Female ; Gallium ; Glass ; Granuloma ; Humans ; Hypersensitivity* ; Lung ; Lymphocytosis ; Male ; Radiography ; Radiography, Thoracic ; Respiratory Function Tests

Primary chondrosarcoma of the heart and its metastasis to the brain is extremely rare. We describe the case ofa patient who underwent resection of cardiac chon-drosarcoma only to relapse with brain metastasis two yearslater. MR images showed that these metastatic tumors were slightly hypointense relative to the brain onT1-weighted images and hyperintense on T2-weighted images. The masses were highly enhanced. Peritumoraledema appeared less extens ive and the focal cystic portion was seen within the mass, corresponding to myxoid degeneration.
Brain Neoplasms* ; Brain* ; Chondrosarcoma* ; Heart ; Humans ; Neoplasm Metastasis ; Recurrence

No abstract available.
Diabetes Insipidus* ; Empty Sella Syndrome*

BACKGROUND: Ski injuries depend on many factors which involve the skier's skill, the skiing environment, and skier's equipment. The purpose of this study was to determine the factors associated with fractures by skiing accident. SUBJECT: We evaluated 566 patients with ski injuries who visited to the emergency post located in the YongPyong Ski Resorts from Nov. 1996 to Feb. 1997. Among the patients,379 patients had no fracture(group I) and 187 patients had fracture(group II). RESULT: There was no differences in mean age and sex ratio between two groups. Fractures of the lower extremities were more common than the upper extremities. Slipping was the most common injury mechanism. arming-up was done in 40% of group I and in 17% of group II. The fracture injuries were more common in the skier with intermediate(45%) skill than the beginner(29%) and the ones with advanced skill(12%). The slope with intermediate difficulty was the most frequent site of fracture accidents. The fracture group tended to choose the slope beyond their skiing ability. CONCLUSION: Our results suggest that fracture during skiing can be prevented if skiers do warming-up prior to skiing and choose slope appropriate to their skiing skill.
Emergencies ; Health Resorts ; Humans ; Lower Extremity ; Sex Ratio ; Skiing ; Upper Extremity

OBJECTIVE: to determine the frequency of the multiple consecutive rib fracture after blunt chest trauma. DESIGN, MATERIALS, AND METHODS: We retrospectively reviewed all the radiographs and medical charts of 87 patients with rib fractures after blunt chest trauma. Rib fractures were divided into single aud multiple. The multiple rib fractures were subclassified as consecutive, interrupted continuous, or random. RESULTS: Thirteen cases of single and 83 cases of multiple rib fractures were present. Among the 83 cases of multiple fractures, there were 73 cases (88%) of consecutive fractures, 5 cases (6%) of interrupted continuous fractures and 5 cases (6%) of random fractures. CONCLUSION: Among the multiple rib fractures consecutive rib fractrues are much more common than noncontiguous rib fractures. We recommend that if one find an apparently nonfractured rib between contiguously fractured upper and lower ribs, one should meticulously search for possible fracture of an apparently normal rib with high-index of suspicion.
Humans ; Retrospective Studies ; Rib Fractures* ; Ribs* ; Thorax*

BACKGROUND: Hepatitis C virus(HCV), a family of Flaviviridae, has a host cell-derived envelope containing a positive-stranded RNA genome, and has been known as the maj or etiological agent for chronic hepatitis, hepatic cirrhosis, and hepatocellular carcinoma. There remains a need to dissect a molecular mechanism of pathogenesis for the development of therapeutic and effective preventive measure for HCV. Identification of cellular receptor is of central importance not only to understand the viral pathogenesis, but also to exploit strategies for prevention of HCV. This study was aimed at identifying peptide mimotopes inhibiting the binding of E2 protein of HCV to MOLT-4 cell . METHODS: In this study, phage peptide library displaying a random peptides consisting of 7 or 12 random peptides was employed in order to pan against E2 protein. Free HCV particles were separated from the immune complex forms by immunoprecipitation using anti-human IgG antibody, and used for HCV-capture ELISA. To identify the peptides inhibiting E2-binding to MOLT-4 cells, E2 protein was subj ect to bind to MOLT-4 cells under the competition with phage peptides. RESULTS: Several phage peptides were selected for their specific binding to E2 protein, which showed the conserved sequence of SHFWRAP from 3 different peptide sequences. They were also able to recognize the HCV particles in the sera of HCV patient s captured by monoclonal antibody against E2 protein. Two of them, showing peptide sequence of HLGPWMSHWFQR and WAPPLERSSLFY respectively, were revealed to inhibit the binding of E2 protein to MOLT-4 cell efficiently in dose dependent mode. However, few membrane-associated receptor candidates were seen using Fasta3 programe for homology search with these peptides. CONCLUSION: Phage peptides containing HLGPWMSHWFQR and WAPPLERSSLFY respectively, showed the inhibition of E2-binding to MOLT-4 cells. However, they did not reveal any homologues to cellular receptors from GenBank database. In further study, cellular receptor could be identified through the screening of cDNA library from MOLT-4 or hepatocytes using antibodies against these peptide mimotopes.
Antibodies ; Antigen-Antibody Complex ; Bacteriophages ; Carcinoma, Hepatocellular ; Conserved Sequence ; Databases, Nucleic Acid ; Enzyme-Linked Immunosorbent Assay ; Flaviviridae ; Gene Library ; Genome ; Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Hepatitis, Chronic ; Hepatocytes ; Humans ; Immunoglobulin G ; Immunoprecipitation ; Liver Cirrhosis ; Mass Screening ; Peptide Library* ; Peptides ; RNA

The authors report a case of cerebral salt wasting(CSW) syndrome followed by diabetes insipidus and meningitis after transsphenoidal approach for pituitary adenoma. Fluid and electrolyte imbalance occurs occasionally in neurosurgical patients due to DI or SIADH, however, CSW is different disease entity and the methods of treatment are different from those of DI or SIADH. A number of studies in recent years have shown that hyponatremia in many patients with intracranial disease might actually be caused by CSW in which a renal loss of sodium leads to hyponatremia and massive urinary water loss. CSW of this patient was resolved by fluid and salt replacement after 6 months.
Diabetes Insipidus ; Humans ; Hyponatremia ; Inappropriate ADH Syndrome ; Meningitis* ; Meningitis, Bacterial ; Pituitary Neoplasms* ; Pseudomonas* ; Sodium ; Wasting Syndrome*