Purpose: This study aimed to identify the factors influencing nurses’ grit, organizational communication satisfaction, and job embeddedness on their organizational commitment. Methods: Data were collected from 174 nurses working in general hospitals in B City, South Korea. Descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis were performed using IBM SPSS/WIN 29.0. Results: Factors influencing organizational commitment included persistence to achieve long-term goals (β=.21, p=.004), organizational climate (β=.23, p=.003), fit (β=.40, p<.001), special unit (β=-.09, p=.045), and clinical career of 1 to 3 years (β=.15, p=.046). The explanatory power of the regression model was 65.7% (F=21.73, p<.001). Conclusion To enhance organizational commitment, nurses should remain focused on achieving long-term goals despite task difficulties. Organizations should not only foster a supportive work environment and establish a positive climate for organizational communication, but also consider the alignment of nurses’ job embeddedness.

Purpose: This study aimed to identify the factors influencing nurses’ grit, organizational communication satisfaction, and job embeddedness on their organizational commitment. Methods: Data were collected from 174 nurses working in general hospitals in B City, South Korea. Descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis were performed using IBM SPSS/WIN 29.0. Results: Factors influencing organizational commitment included persistence to achieve long-term goals (β=.21, p=.004), organizational climate (β=.23, p=.003), fit (β=.40, p<.001), special unit (β=-.09, p=.045), and clinical career of 1 to 3 years (β=.15, p=.046). The explanatory power of the regression model was 65.7% (F=21.73, p<.001). Conclusion To enhance organizational commitment, nurses should remain focused on achieving long-term goals despite task difficulties. Organizations should not only foster a supportive work environment and establish a positive climate for organizational communication, but also consider the alignment of nurses’ job embeddedness.

Purpose: This study aimed to identify the factors influencing nurses’ grit, organizational communication satisfaction, and job embeddedness on their organizational commitment. Methods: Data were collected from 174 nurses working in general hospitals in B City, South Korea. Descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis were performed using IBM SPSS/WIN 29.0. Results: Factors influencing organizational commitment included persistence to achieve long-term goals (β=.21, p=.004), organizational climate (β=.23, p=.003), fit (β=.40, p<.001), special unit (β=-.09, p=.045), and clinical career of 1 to 3 years (β=.15, p=.046). The explanatory power of the regression model was 65.7% (F=21.73, p<.001). Conclusion To enhance organizational commitment, nurses should remain focused on achieving long-term goals despite task difficulties. Organizations should not only foster a supportive work environment and establish a positive climate for organizational communication, but also consider the alignment of nurses’ job embeddedness.

Purpose: This study aimed to identify the factors influencing nurses’ grit, organizational communication satisfaction, and job embeddedness on their organizational commitment. Methods: Data were collected from 174 nurses working in general hospitals in B City, South Korea. Descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis were performed using IBM SPSS/WIN 29.0. Results: Factors influencing organizational commitment included persistence to achieve long-term goals (β=.21, p=.004), organizational climate (β=.23, p=.003), fit (β=.40, p<.001), special unit (β=-.09, p=.045), and clinical career of 1 to 3 years (β=.15, p=.046). The explanatory power of the regression model was 65.7% (F=21.73, p<.001). Conclusion To enhance organizational commitment, nurses should remain focused on achieving long-term goals despite task difficulties. Organizations should not only foster a supportive work environment and establish a positive climate for organizational communication, but also consider the alignment of nurses’ job embeddedness.

Purpose: This study aimed to identify the factors influencing nurses’ grit, organizational communication satisfaction, and job embeddedness on their organizational commitment. Methods: Data were collected from 174 nurses working in general hospitals in B City, South Korea. Descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis were performed using IBM SPSS/WIN 29.0. Results: Factors influencing organizational commitment included persistence to achieve long-term goals (β=.21, p=.004), organizational climate (β=.23, p=.003), fit (β=.40, p<.001), special unit (β=-.09, p=.045), and clinical career of 1 to 3 years (β=.15, p=.046). The explanatory power of the regression model was 65.7% (F=21.73, p<.001). Conclusion To enhance organizational commitment, nurses should remain focused on achieving long-term goals despite task difficulties. Organizations should not only foster a supportive work environment and establish a positive climate for organizational communication, but also consider the alignment of nurses’ job embeddedness.

Purpose: This study investigated medical educators’ readiness for online teaching by exploring their perceived ability and importance of online teaching competencies and identified the highest priority of their educational needs. Methods: In this study, 144 medical education faculty members from a university were invited to participate. The faculty online teaching readiness scale was virtually distributed at the end of the spring semester of 2020 and 38 faculty members responded for 2 weeks. The collected data were analyzed with descriptive statistics, paired t-tests, Borich Needs Assessment, and the Locus for Focus model. Results: The overall average perceived ability was 2.76, while the overall average perceived importance was 3.36. The course design and the technical competency categories showed the highest and lowest educational needs, respectively. Five competencies were given the highest priority of educational needs. Conclusion The results revealed that the medical educators are not ready for online teaching; thus, urgent educational needs for online teaching competencies exist.

During the last two decades, there has been an increasing interest in the impact of oral health on atherosclerosis and subsequent cardiovascular disease (CVD). To date, some periodontal pathogens including Porphyromonas gingivalis (P. gingivalis) have been reported to be relevant to CVD. Porphyromonas endodontalis (P. endodontalis), which shares approximately 87% sequence homology with P. gingivalis, is mostly found within infected root canals. However, recent studies reveal that this pathogen also resides in the dental plaque or periodontal pocket in patients with periodontitis. It has been shown that P. endodontalis invades human coronary artery endothelial cells (HCAEC) and coronary artery smooth muscle cells (CASMC). To evaluate whether P. endodontalis can participate in the progression of atherosclerosis and CVD, we examined the changes in transcriptional gene expression profiles of HCAEC responding to invasion by P. endodontalis in this study. The following results were obtained. 1. Porphyromonas endodontalis was invasive of HCAEC. 2. According to the microarray analysis, there were 625 genes upregulated more than two-folds, while there were 154 genes downregulated by half. 3. Upregulated genes were relevant to inflammatory cytokines, apoptosis, coagulation and immune response. Enhanced expression of MMP-1 was also noticeable. 4. The transcription profiles of the 10 selected genes examined by real-time PCR agreed well with those observed in the microarray analysis. Thus, these results show that P. endodontalis presents the potential to trigger and augment atherosclerosis leading to CVD.
Apoptosis ; Atherosclerosis ; Cardiovascular Diseases ; Coronary Vessels ; Cytokines ; Dental Plaque ; Dental Pulp Cavity ; Endothelial Cells ; Gene Expression ; Humans ; Microarray Analysis ; Myocytes, Smooth Muscle ; Oral Health ; Periodontal Pocket ; Periodontitis ; Porphyromonas ; Porphyromonas endodontalis ; Porphyromonas gingivalis ; Real-Time Polymerase Chain Reaction ; Sequence Homology ; Transcriptome

Background: A rapid increase in bone turnover and bone loss has been observed in response to the discontinuation of denosumab. It led to an acute increase in the fracture risk, similar to that observed in the untreated patients. We aimed to investigate the effect of denosumab on osteoclast (OC) precursor cells compared to that of zoledronate. Methods: The study compared the effects of denosumab (60 mg/24-week) and zoledronate (5 mg/48-week) over 48 weeks in postmenopausal women with osteoporosis. From patients’ peripheral mononuclear cells, CD14+/CD11b+/vitronectin receptor (VNR)- and CD14+/CD11b+/VNR+ cells were isolated using fluorescent-activated cell sorting, representing early and late OC precursors, respectively. The primary endpoint was the changes in OC precursors after 48 weeks of treatment. Results: Among the 23 patients, 11 were assigned to the denosumab group and 12 to the zoledronate group (mean age, 69 years). After 48 weeks, the changes in OC precursors were similar between and within the groups. Serum C-terminal telopeptide of type I collagen levels were inversely correlated with OC precursor levels after denosumab treatment (r=-0.72, P<0.001). Lumbar spine, femur neck, and total hip bone mineral density (BMD) increased in both groups. Lumbar spine BMD increased more significantly in the denosumab group than in the zoledronate group. Conclusions Denosumab and zoledronate treatments induced similar changes in OC precursors. During denosumab treatment, old age and suppressed bone turnover were associated with increased OC precursor cell populations. Further validation studies with prospective designs are required.

BACKGROUND: The herbicides used in Vietnam were later found to be extremely contaminated with 2,3,7, 8-tetrachlorodibenzo-rho-dioxin (TCDD). The carcinogenecity of the product was for all cancers combined. The risk of soft tissue sarcoma, lung cancer, and lymphoma, chloracne, peripheral neuropathy and other diseases were found to be increased. Although many veterans exposed to herbicides had chronic skin diseases with variable clinical features, there were few researches about herbicides-related skin diseases. The purpose of this study was to investigate the characteristics of herbicides-related skin diseases and to provide epidemiologic information. METHODS: This study has been reviewed in the clinical findings of 127 veterans with skin diseases exposed to herbicides who visited Kosin University Gospel Hospital during the 5 years from January of 1997 to December of 2001. RESULTS: The age distribution was in the range of 47~68 years. The mean age was 54.6 years old. All patients were male. In the duration, 34 patients (26.8%) developed skin diseases for 6~10 years, 21 patients (16.5%) for 16~20 years, and 21 patients (16.5%), 25 years. In the incidence, seborrheic dermatitis was the most frequently observed in 45 patients (35.4%) followed by eczematous dermatitis in 41 patients (32.3%), xerotic eczema in 23 (18.1%) and pruritic dermatoses in 21 (16.5 %). In the incidence ratio of skin diseases with systemic diseases, chronic urticaria was the most highly observed with 100% (1/1) followed by fungal infection in 70% (7/10), other diseases in 66.6% (6/9), seborrheic dermatitis in 64.4% (29/45), eczematous dermatitis in 56.1% (23/41), and xerotic eczema in 52.2% (12/23). Sixty eight patients had skin diseases with systemic disease. Hypertension and diabetes were most frequently observed with 24 and 23 patients, respectively. The order of incidence was as follows: liver disease, gastroduodenal ulcer, peripheral neuropathy, chronic gastroenteritis, and hyperlipidemia. Mycosis fungoides was found in 4 cases and monoclonal T cell gamma receptor gene rear-rangement was detected in 2 cases (50%). CONCLUSION: Skin diseases among veterans exposed to herbicides used in Vietnam was chronic and showed variable clinical features. It was difficult to confirm the relationship between skin diseases and herbicides, but further researches are required to seek guidelines for the evaluation of skin diseases.
Age Distribution ; Chloracne ; Chronic Disease ; Dermatitis, Seborrheic ; Eczema ; Gastroenteritis ; Herbicides* ; Humans ; Hyperlipidemias ; Hypertension ; Incidence ; Liver Diseases ; Lung Neoplasms ; Lymphoma ; Male ; Mycosis Fungoides ; Peptic Ulcer ; Peripheral Nervous System Diseases ; Sarcoma ; Skin Diseases* ; Skin* ; Urticaria ; Veterans* ; Vietnam*

BACKGROUND: Cough and hyperdynamic reaction cause considerable discomfort, and they may lead to postoperative surgical complication. To reduce coughing and hemodynamics during emergence, the efficacy of laryngotracheal spraying with lidocaine before intubation is not clear, particularly, in children. We investigated such effect during emergence from general anesthesia, in children. METHODS: Children were studied in a double blind manner: 105 ASA physical status I-II, aged 2-16 yrs, undergoing tonsillectomy and adenoidectomy. Patients were randomly grouped into three (A, B, and C) by the lidocaine spray before endotracheal intubation: 4% lidocaine to the group A (n = 32), 10% lidocaine to the group B (n = 36), and normal saline to the group C (n = 37). The same dose (2 mg/kg) of lidocaine was applied. During emergence, patients were observed their cough and hemodynamics. RESULTS: Lidocaine spray, irrespective of concentration, did not significantly diminish the cough and the hemodynamic reaction across the groups before and after the extubation as well as in the recovery room (P value = 0.44, 0.86, 0.17). CONCLUSIONS: These findings support that the laryngotracheal spraying with lidocaine (2 mg/kg of 4% and 10%) before endotracheal intubation does not reduce the cough and hemodynamic reactions during emergence from general anesthesia in children.
Adenoidectomy ; Anesthesia, General ; Child* ; Cough* ; Hemodynamics* ; Humans ; Incidence* ; Intubation ; Intubation, Intratracheal* ; Lidocaine* ; Recovery Room ; Tonsillectomy