1.A Study of Nucleolar Organizer Regions in Normal and Neoplastic Epithelial Cells of Stomach.
Hee Jin CHANG ; Kyung Ha KANG ; Jung Hee PARK ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Pathology 1992;26(5):451-458
Nucleolar organizer regions are DNA loops encoding rihbosomal RNA production and detectable by the argyrophilia of their associated proteins(AgNORs). AgNOR numbers correlate with cellular proliferating activity. Many studies have shown a significnt difference in AgNOR counts between benign and malignant tumors. AgNOR counts were also helpful in differential diagnosis. For the evaluation of its diagnostic utility in gastric lesions, a silver staining technique was carried out in paraffin sections of 5 control cases, 5 benign peptic ulcers, 7 hyperplastic polyps, 10 tubular adenomas, 16 early gastric adenocarcinomas and 15 advanced gastric adenocarcinomas. The results were as follows. The mean numbers of AgNORs in early and advanced gastric adenocarcinomas(1.94 and 2.16) were significantly higher than those of normal foveolar epithelium(1.43) and epithelia of benign gastric ulcers(1.54), hyperplastic polyps(1.64) and tubular adenomas(1.79). In malignancy, there was increased variability in size and shape of AgNORs. There was little differences in mean AgNOR numbers between early and advanced gastric adenocarcinomas. Differentiation of the tumor made no difference in AgNOR numbers. From the above results, the AgNORs count, if its morphologic change are taken into consideration, is helpful in differentiation between malignant and non-malignant lesions.
Diagnosis, Differential
;
Adenocarcinoma
2.Progression of Dermatofibrosarcoma Proruberans to Malignant Fibrous Histiocytoma: Report of a case.
Hye Rim PARK ; Eun Ha JUNG ; Jin Hee SOHN
Korean Journal of Pathology 1997;31(12):1324-1327
A 52-year-old woman was admitted with a palpable mass on the abdominal wall. This tumor had developed at the same site of a previously resected dermatofibrosarcoma protuberans. The biopsy specimen from the recurrent tumor revealed malignant fibrous histiocytoma. Immunohistochemistry with anti-CD34 antibody revealed diffuse linear positivity on the tumor cells of dermatofibrosarcoma protuberans and negativity on malignant fibrous histiocytoma. Anti CD34 antibody was valuable for a differential diagnosis of these two lesions.
Abdominal Wall
;
Biopsy
;
Dermatofibrosarcoma*
;
Diagnosis, Differential
;
Female
;
Histiocytoma, Malignant Fibrous*
;
Humans
;
Immunohistochemistry
;
Middle Aged
3.The in vitro distribution of 99mTc-phytate IL-2 complex on selective splenic arterial injection.
Seok Kil SEON ; Hee Jung LEE ; Soo Sang SOHN
Korean Journal of Nuclear Medicine 1992;26(1):124-126
No abstract available.
Interleukin-2*
4.Adenoid Cystic Carcinoma of the Breast: A case report.
Eun Ha JUNG ; Hye Rim PARK ; Jin Hee SOHN
Korean Journal of Pathology 1999;33(4):299-302
Adenoid cystic carcinoma (ACC) of the breast is an uncommon carcinoma accounting for less than 1% of the breast carcinoma. This type of carcinoma has a distinctive histology, such as cylindromatous, cribriform, glandlike space and solid pattern in the variable proportion. Prognosis is favorable with rare recurrence or metastasis and the guideline for therapy is not well established. We experienced a case of ACC of right breast in the 48 year-old woman. Cytologically, it showed numerous three-dimensional, well outlined cell clusters with central core of homogeneous, eosinophilic material. The mass was well demarcated, firm and measured 2.5 2.5 2 cm. Cut surface was yellowish white and granular with focal necrosis. Histologically, the tumor was composed of cylindromatous, adenoid and solid area with marked cellular atypia. Focal invasion was identified in the adipose tissue around the tumor. Histologic and nuclear grade was III by Kleer's grade. Nodal metastasis was not found.
Adenoids*
;
Adipose Tissue
;
Breast Neoplasms
;
Breast*
;
Carcinoma, Adenoid Cystic*
;
Eosinophils
;
Female
;
Humans
;
Middle Aged
;
Necrosis
;
Neoplasm Metastasis
;
Prognosis
;
Recurrence
5.Herpes Simplex Esophagitis: A report of two cases.
Eun Ha JUNG ; Hae Kyung AHN ; Jin Hee SOHN
Korean Journal of Pathology 1999;33(4):288-291
Herpes simplex esophagitis has been recognized with increased frequency as an opportunistic infection in immunosuppressed or debilitated patients. However, it is also documented as self-limited esophagitis in apparently healthy patients. We report two cases of herpetic esophagitis diagnosed by biopsies. One case was noted in an immunocompetent patient having gastric peptic ulcer who had clinical improvement with symptomatic treatment. And the other was noted in an immunosuppressed patient having chemotherapy for gastric carcinoma who had resolution of symptoms with acyclovir therapy. Histologically, esophageal mucosa exhibited erosion and inflammatory cellular exudate with intranuclear eosinophilic inclusions in the epithelial cells. These were confirmed by the PCR and immunohistochemical stain for herpes simplex virus using a biopsy material.
Acyclovir
;
Biopsy
;
Drug Therapy
;
Eosinophils
;
Epithelial Cells
;
Esophagitis*
;
Exudates and Transudates
;
Herpes Simplex*
;
Humans
;
Mucous Membrane
;
Opportunistic Infections
;
Peptic Ulcer
;
Polymerase Chain Reaction
;
Simplexvirus
6.Angiofollicular Lymph Node Hyperplasia(Castleman's disease): 3 cases report.
Jeong Hee PARK ; Gil Ro HAN ; Hee Jin CHANG ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Pathology 1992;26(3):298-305
Angiofollicular lymph node hyperplasia(AFLNH) was first described in 1956 by Castleman et al. It was initially reported as a solitary mediastinal mass but multicentric and extranodal disease is now well known. Histologically two distinct variants, e.g. the hyaline vascular type and the plasma cell type, of AFLNH are recognized. And the plasma cell type is typically associated with clinical syndrome consisting of fever, anemia, elevated erythrocyte sedimentation rate and polyclonal hypergammaglobulinemia. Recently, we experineced three cases of AFLNH. Histologically, two cases were hyaline vascular type, that were presented as a right supraclavicular mass of 49-year-old female, and as an anterior mediastinal mass of 53-year-old female. The remaining one case was plasma cell type that was presented as a left axillary mass of 63-year-old male. The former two cases showed typical features of hyaline vascular type but in case 1, exuberant proliferation of hyalinized vessels of capillary size was characteristic feature. The latter case of plasma cell type characteristically showed clinical syndrome consisting of fever, hypoalbuminemia, polyclonal hypergammaglobulinemia. All cases were presented as a single mass and they were well after surgical excision.
Female
;
Humans
7.Cytologic feature of papillary carcinoma of the thyroid.
Jeong Hee PARK ; Hee Jin CHANG ; Kyung Ha KANG ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Cytopathology 1991;2(2):111-118
No abstract available.
Carcinoma, Papillary*
;
Thyroid Gland*
8.Myelodysplastic syndrome Transformed into Erythroleukemia.
Sun Hee KIM ; Don Hee AHN ; Keun Chan SOHN ; Jung Il SUH ; Jung Hee UM ; Hea Ran PARK
Journal of the Korean Pediatric Society 1985;28(12):1231-1237
No abstract available.
Leukemia, Erythroblastic, Acute*
;
Myelodysplastic Syndromes*
9.The Expression of Interleukin-6 in Chronic CCl4-induced Hepatotoxicity in Ethanol-fed Rabbits.
Sung Sook KIM ; Yeong Ju WOO ; Eun Hee HA ; Hee Jung SOHN ; Inpyoi CHOI
Korean Journal of Occupational and Environmental Medicine 1997;9(3):508-516
No abstract available.
Interleukin-6*
;
Rabbits*
10.Eosinophilia in Premature Infant's.
Ho Jin LEE ; Jung Woo SUK ; Kyang Chun JUNG ; Don Hee AHN ; Keun Chan SOHN
Journal of the Korean Pediatric Society 1981;24(3):216-220
No abstract available.
Eosinophilia*