1.A case of cutaneous metastasis probably originating from primary gallbladder carcinoma.
Seung Heon KHANG ; Hee Jin JO ; Kwang Joong KIM ; Chong Ju LEE
Korean Journal of Dermatology 1991;29(5):676-680
No abstract available.
Gallbladder*
;
Neoplasm Metastasis*
2.Polymorphisms Linked to Factor IX Gene in Korean Population.
Joong Sik SHIN ; Sung Ro JUNG ; Il Pyo SON ; Yool Hee JO
Korean Journal of Obstetrics and Gynecology 2000;43(11):2038-2044
OBJECTIVE: Linkage analysis is a very useful method for prenatal diagnosis of Hemophilia B, especially when a mutation was not identified. Seven polymorphic markers were studied in Korean populations to evaluate the efficiency for prenatal and carrier diagnosis. METHODS: Subjects of this study was 100 healthy Korean women (200 X-chromosomes). Polymerase chain reacton-restriction fragment length polymorphism (PCR-RFLP) method was used to detect SalI, MseI, NruI, DdeI, XmnI, TaqI and HhaI polymorphisms. RESULTS: SalI (-) allele showed the frequency of 0.355 and SalI(+) allele 0.645. MseI(-) allele was 0.645 in frequency and MseI(+) allele was 0.355. SalI and MseI polymorphisms were in complete linkage disequilibrium. And no increase was expected in overall heterozygosity with these two polymorphisms. NruI(-) allele frequency was 0.855 and NruI(+) was 0.145. There was no polymorphism of DdeI, XmnI and TaqI marker systems in Korean population. In HhaI polymorphism, allele frequencies were estimated that HhaI(-) is 0.82 and HhaI(+) is 0.18. CONCLUSION: Only SalI, NruI and HhaI polymorphisms are useful for the diagnosis of hemophilia B in Korean population. Expected heterozygosity for above 3 poylmorphic markers was estimated to be 0.723, and 71 of 100 female subjects were heterozygous for at least one marker system. Korean population showed relatively low extent of polymorphisms compared to Caucasians, Blacks and Japanese. For the effective prenatal diagnosis of hemophilia B with linkage analysis, other polymorphic markers should be evaluated.
African Continental Ancestry Group
;
Alleles
;
Asian Continental Ancestry Group
;
Diagnosis
;
Factor IX*
;
Female
;
Gene Frequency
;
Hemophilia B
;
Humans
;
Linkage Disequilibrium
;
Prenatal Diagnosis
3.Two Cases of Acardiac Acephalus.
Tae Hee KIM ; Hwang KWON ; Joong Sik SHIN ; Jung Bae YOO ; Chang Jo CHUNG
Korean Journal of Perinatology 2001;12(4):499-503
No abstract available.
4.Distribution of Neuropeptide mRNA-Containing Neurons and Changes of Their Gene Expression in the Rat Periaqueductal Gray in a Neuropathic Pain Model.
Sang Myung HUH ; Jung Gee KIM ; Myung Ae BAE ; Dong Sun KIM ; Mae Ja PARK ; Hee Joong JO
Korean Journal of Anatomy 1997;30(3):205-214
The distribution of enkephalin, dynorphin, substance P and neurotensin in the periaqueductal gray[PAG] has been well established by immunohistochemical methods. However, there is little information about the regional distribution of these neuropeptide mRNA-containing neurons in the PAG. The present study was undertaken [1] to elucidate the distribution of these neuropeptide mRNA-containing neurons and to determine of the PAG, [2] to know how peptide expression relates to the proposed functional subdivisions of the PAG and [3] to know how neuropeptide mRNA levels in the PAG change following peripheral neuropathy The results obtained are as follows ; 1. Preproenkephalin[pENK] mRNA-containing neurons are found mostly in the ventrolateral portion at all levels of the PAG. 2. Prodynorphin[pDYN] mRNA-containing neurons are concentrated mostly in the ventrolateral portion at the caudal level of the PAG. 3. Preprotachykinin[pTAK] mRNA-containing neurons are localized mainly in the ventrolateral portion at all levels of the PAG. There is small numbers of pTAK mRNA-containing neurons in the dorsolateral and dorsal portion at all levels of the PAG. 4. Proneurotensin[pNT] mRNA-containing neurons are concentrated mostly in the medial part of ventrolateral portion of the caudal and mid PAG. 5. Peripheral neuropathy induces an increase of pNT mRNA levels in the PAG, while pENK, pDYN and pTAK mRNAs levels show no change. The present results indicate that the pENK, pDYN, pTAK or pNT mRNA-containing neurons are found mainly in the ventrolateral PAG, the area where analgesia is most easily produced and that neurotensin in the PAG may play an important role in modulating chronic neuropathic pain.
Analgesia
;
Animals
;
Dynorphins
;
Enkephalins
;
Gene Expression*
;
In Situ Hybridization
;
Neuralgia*
;
Neurons*
;
Neuropeptides*
;
Neurotensin
;
Periaqueductal Gray*
;
Peripheral Nervous System Diseases
;
Rats*
;
RNA, Messenger
;
Substance P
5.Distribution of Tyrosine Hydroxylse Immunoreactive Structure in the Spinal Cord and Dorsal Root Ganglion of the Rat.
Yong Joo KIM ; Ji Yoon KIM ; Dong Sun KIM ; Hee Joong JO ; Yong Chul BAE ; Mae Ja PARK
Korean Journal of Anatomy 1997;30(2):147-153
With the aim of gaining more insight into the catecholaminergic system in the nervous system of the rat, we have studied the precise distribution pattern of the tyrosine hydroxylase immunoreactive[TH-IR] fibers and soma in the spinal cord and dorsal root ganglion. In the dorsal root ganglion[DRG], TH-IR fibers were observed to run along the vessel wall, spirally and not found in the neural tissue itself. A few TH-IR fibers were found in the spinal nerve, not in the ventral root. Many TH-IR neurons were distributed in the L3, 4, 5, and 6 DRG but none of them were found in the other DRG segments. In the spinal cord, TH-IR fibers have shown sparse distribution all over spinal cord but relatively dense distribution in the ventral horn, intermediolateral column, lamina I of the dorsal horn of the cervical, lumbar, sacral, and coccygeal segment. TH-IR neurons were found in the intermediolateral column, dorsal gray commissure, dorsal horn of the C1 and C2 segments and S1-4 segments. TH-IR neurons in the cervical segments were polygonal and spindle shaped with well developed processes. In contrast to this, TH-IR neurons in the sacral segments were oval or spindle shaped with no processes. In conclusion, neurons in the DRG were not influenced by catecholaminergic nervous input. Intrinsic catecholaminergic nervous systems were found in both of spinal cord and DRG.
Animals
;
Carisoprodol
;
Diagnosis-Related Groups
;
Ganglia, Spinal*
;
Horns
;
Immunohistochemistry
;
Nervous System
;
Neurons
;
Rats*
;
Spinal Cord*
;
Spinal Nerve Roots*
;
Spinal Nerves
;
Tyrosine 3-Monooxygenase
;
Tyrosine*
6.A Case of Aleukemic Leukemia Cutis.
Sang Hun LEE ; Chul Woo KIM ; Hee Jin JO ; Kwang Ho KIM ; Kwang Joong KIM
Annals of Dermatology 2006;18(2):86-90
Aleukemic leukemia cutis is a rare condition characterized by invasion of leukemic cells in the skin before their appearance in the peripheral blood or bone marrow. We report a case of a 24-year-old man who presented with a 2-month history of nodules on his chin and left thigh. His medical history included acute myelocytic leukemia which had been in complete remission for 13 years and seminoma of the right testis which had been treated with orchiectomy 1 year before. Biopsy of the cutaneous lesions revealed infiltrating cells characterized by irregular shaped or kidney bean-shaped nuclei with abundant pale, slightly eosinophilic cytoplasm. These atypical cells stained positive for leukocyte common antigen, lysozyme and myeloperoxidase. His peripheral blood examination and bone marrow biopsy failed to demonstrate leukemic changes. With these results, a diagnosis of aleukemic leukemia cutis was made. We then performed another immunohistochemical stain for lysozyme and myeloperoxidase on the testicular specimen which had been diagnosed as seminoma 1 year previously. The tumor cells of seminoma were lysozyme- and myeloperoxidase-positive. We were also able to diagnose seminoma as isolated granulocytic sarcoma. A complete remission of the cutaneous lesion was achieved with chemotherapy, but recurrent leukemia cutis reappeared six months later. He underwent a bone marrow transplant but died 3 months later.
Antigens, CD45
;
Biopsy
;
Bone Marrow
;
Chin
;
Cytoplasm
;
Diagnosis
;
Drug Therapy
;
Eosinophils
;
Humans
;
Kidney
;
Leukemia*
;
Leukemia, Myeloid, Acute
;
Muramidase
;
Orchiectomy
;
Peroxidase
;
Sarcoma, Myeloid
;
Seminoma
;
Skin
;
Testis
;
Thigh
;
Young Adult
7.The effect of formaldehyde on neurobehavioral performance of student during cadaver dissection.
Yong SAKONG ; Hee Yoon JO ; In Gook LEE ; Kyeong Soo LEE ; Man Joong JUN
Yeungnam University Journal of Medicine 2016;33(2):85-89
BACKGROUND: Formaldehyde is used to preserve cadaver in medical schools, and students are exposed to formaldehyde during cadaver dissection classes. When humans are exposed to formaldehyde, it induces mucosal inflammation, skin inflammation, and declining of neurobehavioral function including attention and memory executive functions. The purpose of this study is to identify the effects of formaldehyde exposure on student's neurobehavioral performance during cadaver dissection classes. METHODS: The level of formaldehyde was measured in a cadaver dissection class. A total of 16 students were randomly divided into two groups. One group wore respiratory protection masks, while the other group did not. Among many subtests in Korean Computerized Neurobehavioral test, backward digit span was tested on all subjects before and after the class. RESULTS: The length of memorized digit span between the two groups was not significant; however there was a greater decrease in neurobehavioral function after formaldehyde exposure in the non-mask group than the mask group. CONCLUSION: Formaldehyde exposure during cadaver dissection may likely decrease neurobehavioral performance of students. Therefore, proper ventilation system and respiratory protective equipment are necessary to protect medical school students from adverse effects of formaldehyde exposure.
Cadaver*
;
Executive Function
;
Formaldehyde*
;
Humans
;
Inflammation
;
Masks
;
Memory
;
Schools, Medical
;
Skin
;
Ventilation
8.Ischemic Stroke Associated with Orthostasis in an Advanced Parkinson's Disease Patient with Orthostatic Hypotension.
Hyun Ah CHOI ; Hyun Jo LEE ; Seung Hee NA ; Hyung Eun PARK ; Joong Seok KIM
Journal of the Korean Neurological Association 2015;33(1):48-50
No abstract available.
Dizziness*
;
Humans
;
Hypotension, Orthostatic*
;
Parkinson Disease*
;
Stroke*
9.A Case of Spiny Keratoderma.
Hyun Joon KIM ; Young Ju SEO ; Chul Woo KIM ; Hee Jin JO ; Kwang Ho KIM ; Kwang Joong KIM
Korean Journal of Dermatology 2006;44(2):193-196
Spiny keratoderma is a rare disorder and consists of multiple tiny keratotic plugs on the fingers and palms, which resemble the spines on a music box. Histopathologically, the lesions show compact columns of parakeratosis, with no granular layer beneath the column and no remarkable changes in the underlying epidermis and dermis. However, it is important to recognize that the disease is associated with internal malignancies. We report a case of spiny keratoderma in a 3-year-old girl, who had no associated underlying disorder.
Child, Preschool
;
Dermis
;
Epidermis
;
Female
;
Fingers
;
Humans
;
Music
;
Parakeratosis
;
Spine
10.Current Status of the Diagnosis and Management of Amyotrophic Lateral Sclerosis in Korea: A Multi-Center Cross-Sectional Study.
Jong Seok BAE ; Yoon Ho HONG ; Wonki BAEK ; Eun Hee SOHN ; Joong Yang CHO ; Byung Jo KIM ; Seung Hyun KIM
Journal of Clinical Neurology 2012;8(4):293-300
BACKGROUND AND PURPOSE: Recently published, evidence-based guidelines should alter the management of amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). However, the newest recommendations for ALS/MND therapy are not reflected in actual clinical practice. We sought to evaluate the current status of the diagnosis and management of ALS in Korea. METHODS: The Korean ALS/MND research group was organized in 2010, involving more than 50 neurologists from neuromuscular centers in Korea. Participating centers collected data from April to September 2010 on the diagnosis and management of patients with ALS. Data forms from the ALS patient care database, which is a component of the ALS clinical assessment, research, and education program (http://www.outcomes-umassmed.org/ALS/), were modified and used for data collection. RESULTS: In total, 373 sporadic ALS cases from 35 centers were enrolled. The demographic features and clinical findings were similar to those in previous reports from other countries. The mean age at onset was 50-60 years, and a slight male predominance was observed. The enrolled patients predominantly showed focal onset of cervical or lumbosacral symptoms. Only about one-half of the indicated patients (31.4%) received a physician's recommendation for a parenteral gastrostomy, and 18.1% underwent the procedure. Noninvasive ventilation was recommended in 23% of patients, but applied in only 9.5% of them. Tracheostomy was performed in 12.7% of patients. CONCLUSIONS: The demographic and clinical features of the diagnosis and management of ALS in Korea are similar to those reported in other countries; however, supportive management, as recommended in evidence-based guidelines, are not yet widely recommended or performed for patients with ALS in Korea.
Amyotrophic Lateral Sclerosis
;
Cross-Sectional Studies
;
Gastrostomy
;
Humans
;
Korea
;
Male
;
Neurons
;
Noninvasive Ventilation
;
Palliative Care
;
Patient Care
;
Tracheostomy