1.Multifocal Brain Infarction and Intraventricular Hemorrhage in an Infant during Treatment of Diabetic Ketoacidosis.
Kyung Ran SON ; Joon Sung KIM ; Hwa Yun LEE ; Ha Young NOH ; Hee Jo BACK ; Young Jong WOO
Journal of Korean Society of Pediatric Endocrinology 2002;7(2):225-229
Fatal complications including cerebral edema and neurologic collapse occur during treatment of diabetic ketoacidosis(DKA). A 6-week-old female infant with fever, dehydration and drowsy mental status was diagnosed as DKA and neurologically deteriorated during treatment. The cranial computed tomography scan revealed multifocal brain infarctions of the left caudate nucleus, bilateral frontal periventricular white matter, and right parietal cortex. A moderate amount of hemorrhage was also noted in both lateral ventricles. She recovered rapidly with supportive treatment over time. The clinical course and radiologic findings of this patient emphasize the importance of brain infarction as a cause of persistent neurologic loss in children with DKA.
Brain Edema
;
Brain Infarction*
;
Brain*
;
Caudate Nucleus
;
Child
;
Dehydration
;
Diabetic Ketoacidosis*
;
Female
;
Fever
;
Hemorrhage*
;
Humans
;
Infant*
;
Lateral Ventricles
;
Rabeprazole
2.Paraquat Poisoning by Injection: 3 autopsy cases.
Youn Shin KIM ; Ho LEE ; Yu Kyoung JUNG ; Ik Jo CHUNG ; Back Hee HAN
Korean Journal of Legal Medicine 2000;24(1):87-91
Paraquat is a bipyridilium nonselective contact herbicide and well-known pulmonary toxicants. Concentrated solution of paraquat may causes severe corrosive injury and multiple system organ failure. It is poorly absorbed from GI tract, but is extremely toxic and so one swallowed mouthful of Gramoxone(about 5ml) will be fatal. We experienced 3 cases of paraquat poisoning through injection and examined pathologic findings, medical records and concentration of paraquat in blood and tissues. We reviewed the mechanism of action of paraquat, pathologic changes of organ system, concentration of compound in the various organ and cause of death in autopsy cases.
Autopsy*
;
Cause of Death
;
Gastrointestinal Tract
;
Medical Records
;
Mouth
;
Paraquat*
;
Poisoning*
3.Hematologic Findings of Toxemia Mothers and Their Babies.
Hee Jo BACK ; Kyung Ran SON ; Chang Yee CHO ; Young Youn CHOI ; Tae Bok SONG
Korean Journal of Perinatology 2002;13(2):147-153
OBJECTIVE: Hematologic abnormalities in toxemia mothers and their babies have been documented. The purpose of this study was to explore the hematologic findings in mothers with toxemia and postnatal hematologic findings in their babies. The relationship of hematologic findings between toxemia mothers before delivery and their babies immediately after birth was also examined. METHODS: Forty-six pairs of singleton toxemia mothers and their babies born by C-section with 28 to 35 weeks of gestation from Jan. 1995 to Dec. 1999 were enrolled. Fifty pairs of singleton normotensive mothers and their babies with the same gestational period and delivery method were matched for control group. Blood samples of mothers were performed before delivery, and those of their babies, were done immediately after birth, day 3 and 7 of life. Hemoglobin(Hb) concentration, total white blood cell(WBC) count, absolute neutrophil count(ANC), and platelet count were examined. RESULTS: Toxemia mothers have significantly lower platelet count compared with controls(191,000+/-83,200/mm3 vs. 252,000+/-92,700/mm3, p<0.05). There were no difference between both groups in Hb, WBC and ANC. On the first day of life, Hb was significantly higher(16.97+/-2.36g/dL vs 14.32+/-1.5g/dL, p<0.05), but WBC, ANC and platelet count were significantly lower in babies born to toxemia mothers than those of control group(p<0.05 for all). In babies born to toxemia mothers, Hb was significantly decreased until the seventh day of life(16.97g/dL, 15.48g/dL, 14.61g/dL, p<0.05), however, WBC and platelet count were significantly decreased until the third day of life and then incresed until the seventh day of life(11,832/mm3, 8,334/mm3, 10,104/mm3 for WBC, p<0.05, and 152,220/mm3, 144,720/mm3, 214,090/mm3 for platelet, p<0.05, respectively). CONCLUSION: Hemoglobin concentration was significantly higher, whereas WBC, ANC and platelet were significantly lower in babies of toxemia mothers than those of control group. In babies born to toxemia mothers, Hb was significantly decreased until the seventh day of life, however, WBC and platelet count were significantly decresed until the third day and then increased until the seventh day of life. There was no relationship between hematologic findings of toxemia mothers and their babies.
Blood Platelets
;
Humans
;
Mothers*
;
Neutrophils
;
Parturition
;
Platelet Count
;
Pregnancy
;
Toxemia*
4.MYH9-related Disorder in a Family: Autosomal Dominant Epstein Giant Platelet Syndrome.
Hee Jo BACK ; Hoon KOOK ; Hyung Suck BYUN ; Eun Song SONG ; So Youn KIM ; Joon Sun LEE ; Eun Kyoung JO ; Ho Song NAM ; Tai Ju HWANG
Korean Journal of Pediatric Hematology-Oncology 2003;10(1):99-104
The term MYH9-related disorders indicates a group of autosomal dominant illnesses, formerly known as May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome and Epstein syndrome, caused by mutations of MYH9, the gene encoding for the heavy chain of non-muscle myosin IIA (NMMHC-IIA). We experienced a family with macrothrombocytopenia without leukocyte inclusion. A 5-year-old girl was found to have macrothrombocytopenia incidentally. Her father also had macrothromtocytopenia, but had been suffering from hearing loss and chronic renal failure. Meticulous search by light and electron microscopy failed to detect leukocyte inclusions. To our knowledge, these cases seem to be the first description of autosomal dominant Epstein giant platelet syndrome in Korea.
Bernard-Soulier Syndrome*
;
Child, Preschool
;
Fathers
;
Female
;
Hearing Loss
;
Humans
;
Kidney Failure, Chronic
;
Korea
;
Leukocytes
;
Microscopy, Electron
;
Nonmuscle Myosin Type IIA
5.Two Cases of Malignant Lymphomas in Children with Selective IgA and IgG Subclass Deficiency.
Ho Song NAM ; Hoon KOOK ; Kyung Ran SON ; Hee Jo BACK ; Seok Joo KIM ; Ji Shin LEE ; Tai Ju HWANG
Korean Journal of Pediatric Hematology-Oncology 2004;11(2):253-259
Selective IgA deficiency is one of the most common primary immunodeficiency. Some patients with IgA deficiency also have deficits in one or more immunoglobulin G subclasses. It has been estimated that up to 25% of patients with certain primary immunodeficiencies will develop tumors, primarily B-cell lymphomas during their lifetime. We hereby present 2 cases of malignant lymphomas, one diffuse large cell lymphoma and another mixed cellularity Hodgkin's disease, respectively, which developed in patients with selective IgA and IgG subclass deficiency.
Child*
;
Hodgkin Disease
;
Humans
;
IgA Deficiency
;
Immunoglobulin A*
;
Immunoglobulin G*
;
Lymphoma*
;
Lymphoma, B-Cell
;
Lymphoma, Large B-Cell, Diffuse
;
Lymphoma, Non-Hodgkin
6.Effects of Single Fetal Death on Mother and Live Co-twin in Twin Pregnancy.
So Youn KIM ; Hae Yul CHUNG ; Hee Jo BACK ; Ic Sun CHOI ; Chang Yee CHO ; Young Youn CHOI
Journal of the Korean Pediatric Society 2002;45(12):1512-1518
PURPOSE: Twins have a higher mortality and morbidity than singletons. Co-twin with one fetal death is particularly at risk. We investigated the neonatal outcome of live co-twins when one fetus had died after the 20th gestational week, and associated risk factors. METHODS: A retrospective study was performed in fifteen cases of twin pregnancy with single intrauterine fetal deaths after the 20th gestational week during the period from January 1996 to December 2000 at Chonnam University Hospital. RESULTS: Gestational age was 33.7+/-3.2 weeks, birth weight was 1,992+/-592 g. Interval between one fetal death being detected and the delivery of a live co-twin was 32.4+/-29.5 days. There were 11 cases(73.3%) of premature babies less than 37 gestational weeks. Main causes of preterm delivery were preterm labor and premature rupture of membranes. Hematologic findings suggesting disseminated intravascular coagulopathy(DIC) were not found in all mothers before delivery, and was not associated with DIC and encephalomalacia of the live co-twin. Perinatal outcome of fifteen live co-twins was as follows : six were normal(40%), three were DIC(20.0%), three were encephalomalacia(20.0%), one suffered intrauterine growth retardation, there was one case of twin to twin transfusion syndrome, and one of congenital heart disease(atrial septal defect with pulmonary stenosis). The occurrence of DIC and encephalomalacia in live co-twins was not related to placental chorionicity, birth weight, gestational week, and the interval between the detection one fetal death and the delivery of a live co-twin. CONCLUSIONS: We could not find any maternal hematologic problems in twin pregnancies complicated by one fetal death. Twenty percent of live co-twins showed DIC and encephalomalacia. However, its associated risk factors were not found. We need to investigate more closely the cases of live co-twins with one intrauterine fetal death.
Birth Weight
;
Chorion
;
Dacarbazine
;
Encephalomalacia
;
Female
;
Fetal Death*
;
Fetal Growth Retardation
;
Fetofetal Transfusion
;
Fetus
;
Gestational Age
;
Heart
;
Humans
;
Jeollanam-do
;
Membranes
;
Mortality
;
Mothers*
;
Obstetric Labor, Premature
;
Pregnancy
;
Pregnancy, Twin*
;
Retrospective Studies
;
Risk Factors
;
Rupture
7.Frequency and clinical characteristics of prenatally diagnosed congenital hydronephrosis and outcomes of ureteropelvic junction stenosis.
Hyun Soo KANG ; June Seung SUNG ; Sun Hui KIM ; Hee Jo BACK ; Young Ok KIM ; Chan Jong KIM ; Young Youn CHOI ; Tai Ju HWANG
Korean Journal of Pediatrics 2006;49(8):870-874
PURPOSE: Popular use of fetal ultrasonography has increased to detect congenital hydronephrosis(CH) which is the most common anomaly prenatally detected. We'd like to determine the frequency and clinical characteristics of prenatally diagnosed CH and outcome of ureteropelvic junction stenosis(UPJS). METHODS: The records of births between January 1994 and June 2003 in Chonnam National University Hospital(CNUH), and the records of children who were diagnosed with CH in the Department of Pediatrics of CNUH during the above period, were retrospectively analyzed. In the patients with UPJS, the initial anterior posterior diameters of renal pelvis(APD) were compared between the spontaneous regression (SR) and operation group(OP). In the SR group, sequential regression rates of APD were estimated. RESULTS: Among a total 9,076 births, 231(2.54 percent) patients with 293 renal units were diagnosed as CH and 19(6.78 percent) renal units spontaneously regressed 3 days after birth. In 228 children(56 bilateral; 172 unilateral; total 284 renal units) diagnosed with CH in the department of pediatrics of CNUH, male(71.9 percent) and left kidney(69.2 percent) predilection were found and 78.1 percent of CH were caused by UPJS. The initial APD of the SR group(121 units) in UPJS was 7.8+/-6.28 mm, which was significantly smaller than the APD(26.8+/-12.14 mm) of the OP group(25 unit)(P<0.05). In the SR group, 81 percent spontaneously regressed within one year. CONCLUSIONS: In CH, male and left kidney predilection were found. UPJS was the most common cause of CH and initial APD in UPJS at 3 days of age was a good prognostic indicator. Close monitoring should be done for at least one year because most SR in UPJS regressed spontaneously within one year.
Child
;
Constriction, Pathologic*
;
Humans
;
Hydronephrosis*
;
Jeollanam-do
;
Kidney
;
Male
;
Parturition
;
Pediatrics
;
Retrospective Studies
;
Ultrasonography, Prenatal
8.Autoradiographic Investigation for 3H-Thymidine Labeling Indicies of gamma-Glutamyl Transpeptidase Positive Foci during the Rat Liver Carcinogenesis.
Kee Woon KWEON ; Hong Joo KIM ; Soong Hwan LEE ; Yeong Jung CHO ; Jong Cheol KIM ; Sung Woo KIM ; Hee Soo KIM ; In Gyu BACK ; Cheol Hun JUNG ; Yong Hyeon JO ; Chang Woo GHAM ; Dong Hoo LEE
The Korean Journal of Hepatology 1998;4(2):162-178
No abstract available.
Animals
;
Autoradiography
;
Carcinogenesis*
;
Diethylnitrosamine
;
gamma-Glutamyltransferase*
;
Liver*
;
Rats*
9.Autoradiographic Investigation for 3H-Thymidine Labeling Indicies of gamma-Glutamyl Transpeptidase Positive Foci during the Rat Liver Carcinogenesis.
Kee Woon KWEON ; Hong Joo KIM ; Soong Hwan LEE ; Yeong Jung CHO ; Jong Cheol KIM ; Sung Woo KIM ; Hee Soo KIM ; In Gyu BACK ; Cheol Hun JUNG ; Yong Hyeon JO ; Chang Woo GHAM ; Dong Hoo LEE
The Korean Journal of Hepatology 1998;4(2):162-178
No abstract available.
Animals
;
Autoradiography
;
Carcinogenesis*
;
Diethylnitrosamine
;
gamma-Glutamyltransferase*
;
Liver*
;
Rats*
10.Complications and Perinatal Factors According to the Birth Weight Groups in the Infants of Diabetic Mothers.
Kyung Ran SON ; Hee Jo BACK ; Chang Yee CHO ; Young Youn CHOI ; Tae Bok SONG ; Chun Hak PARK
Journal of the Korean Pediatric Society 2003;46(5):447-453
PURPOSE: This study was performed to compare complications and perinatal factors according to the birth weight groups in the infants of diabetic mothers(IDM). METHODS: Three hundred and one singleton diabetic mothers and their babies of more than 30 weeks' gestational age admitted in the department of Pediatrics, Chonnam University Hospital from January 1996 to March 2002 were enrolled. Complications and perinatal factors were compared between large for gestational age(LGA) and appropriated for gestational age(AGA) infants. RESULTS: Hypomagnesemia was observed in 37.5%, jaundice in 21.3%, hypoglycemia in 11.1%, hypocalcemia in 7.0%, and birth injury in 19.6%. Congenital anomaly was noted in 24.9% with cardiovascular anomaly most commonly. In the LGA group, the frequencies of jaundice, hypoglycemia, tachypnea, and birth injuries were higher, and the interventricular septum was thicker than the AGA group. In the LGA group, Cesarean section rate, maternal height, weight before pregnancy, weight gain during pregnancy, and the incidence of unawareness of gestational DM were significant compared with the AGA group. CONCLUSION: In the LGA group, the frequencies of jaundice, hypoglycemia, tachypnea, and birth injuries were higher, and the interventricular septum was thicker than the AGA group. In the LGA group, maternal height, weight before pregnancy and weight gain during pregnancy were larger, and the incidence of unawareness of gestational DM was higher compared with the AGA group. These results suggest that careful examination and management are needed to detect the high risk, pregnant DM mothers with possible LGA babies.
Birth Injuries
;
Birth Weight*
;
Cesarean Section
;
Female
;
Gestational Age
;
Humans
;
Hypocalcemia
;
Hypoglycemia
;
Incidence
;
Infant*
;
Jaundice
;
Jeollanam-do
;
Mothers*
;
Parturition*
;
Pediatrics
;
Pregnancy
;
Tachypnea
;
Weight Gain