1.A Case of Wells' Syndrome Associated with Pancreatic Carcinoma.
Jin Hyoung KIM ; So Yun CHO ; Jeong Hee HAHM
Korean Journal of Dermatology 1999;37(6):785-789
Wells' syndrome or eosinophilic cellulitis is an uncommon cutaneous disorder characterized by recurrent erythematous and edematous plaques that often resemble acute cellulitis. The characteristic microscopic findings are diffuse dermal eosinophilia with marked edema, and flame figures consisting of amorphous or granular eosinophilic material around collagen bundles of the dermis. Etiology and pathogenesis are unknown, but the disease has been found to be associated with infections, arthropod bites, drug administration, surgery and hematologic disorders. We report the case of a 55-year-old man with pancreatic carcinoma who was presented with an asymptomatic erythematous to brownish subcutaneous nodule on the left buttock of several days' duration. A biopsy specimen taken from the erythematous to brownish nodule showed many flame figures and diffuse infiltration of eosinophils in the dermis and subcutaneous fat tissue. The rapid resolution of the skin lesion with chemotherapy of the pancreatic carcinoma supports a relationship between the two conditions.
Arthropods
;
Biopsy
;
Buttocks
;
Cellulitis
;
Collagen
;
Dermis
;
Drug Therapy
;
Edema
;
Eosinophilia
;
Eosinophils
;
Humans
;
Middle Aged
;
Skin
;
Subcutaneous Fat
2.Acute Gastric Anisakiasis: A case report.
So Young JIN ; Soon Hee JUNG ; Tai Seung KIM
Korean Journal of Pathology 1989;23(1):149-153
We report a case of a 41-year-old female patient who suffered from the acute abdominal pain for several hours after eating raw sea-fishes. After the fibergastroscopy and the abdominal C-T scan, the clinicians found a gastric submucosal mass and performed the explolaparotomy to get an wedge of stomach. Sections revealed a larva surrounded by phlegmonous inflammation with intense eosinophilic infiltration in the widened gastic submucosa. The larva presented the characteristics of the Anisakis: two lateral chords with renette cell, thich smooth cuticle and well developed musculature.
Female
;
Humans
3.Edwards Syndrome: an autopsy case.
So Young JIN ; Woo Hee JUNG ; Chang Ho HONG
Korean Journal of Pathology 1986;20(3):343-348
Edwards syndrome is first introduced by Edwards and characterized by facial anomalies, multiple cardiovascular, gastrointestinal, urogenital, and skeletal malformations. It results from triplication of part or all of chromosome 18 in some or all of the patient's cells. It has an incidence of 1 in 4,500 live births or less and short life expectancy. Recently we experienced a case of 3-day-old female new born infant with this syndrome. Post mortem examination showed progeric face with prominent occiput, large flabby ears, microphthalmia, and micrognathia, bilateral clenched hands with flexion contraction of middle fingers, and bilateral rockerbottom feet. Internal examination revealed horseshoe kidney, esophageal atresia with tracheoesophageal fistula, two accessory spleens, and multiple cardiac anomalies. A trisomy 18 was confirmed by the cytogenetic study.
Infant
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Male
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Female
;
Infant, Newborn
;
Humans
;
Incidence
4.Is CT Effective in Diagnosing the Acute Appendicitis?: Focus on Comparison of Unenhanced CT with Barium Enema.
Seong Hee CHOI ; So Hee HAHM ; Jin Hwa KANG ; Jeong Hwa MOON
Journal of the Korean Radiological Society 1994;31(1):91-98
PURPOSE:To evaluate the role of unenhanced CT in diagnosing the acute appendicitis. METHOD AND MATERIALS: We retrospectively analyzed conventional contrast-enhanced abdominal CT scans of 197 normal patients and barium enemas of 26 out of the 197 patients. Additional unenhanced CT scans of right lower abdomen were performed on 30 patients who were suspected of having acute appendicitis;barium enema was performed in 26 patients. RESULTS: in the analysis of the conventional CT scans, we could detect 132(67%) normal appendicies. On barium enema of 26 out of 197 patients, abruptly narrowed appendix was visualized in 5 cases and luminal irregularity in 4 cases but all 26 cases showed normal appendix on CT. In the 30 cases of unenhanced CT, all appendicies were visualized. Among 12 Cases which were proved as acute appendicitis, barium enenma was done in 10 case;abruptly narrowed appendix was shown in 3 and luminal irregularity in 1. Among 18 cases which were diagnosed as normal appendix, nonvisualization of appendix' was in 1 case, abruptly narrowed lumen in 3, and luminal irregularity in 9. CONCLUSION:Unenhanced CT in the area of the cecum may be an effective and safe diagnostic tool for acute appendicitis.
Abdomen
;
Appendicitis*
;
Appendix
;
Barium*
;
Cecum
;
Enema*
;
Humans
;
Phenobarbital
;
Retrospective Studies
;
Tomography, X-Ray Computed
5.Phamacokinetics of Sustained-release Formulation of Growth Hormone in Experimental Animal.
Myung jin KIM ; Sun Jin KIM ; Duk Hee KIM ; So Chung CHUNG
Journal of Korean Society of Pediatric Endocrinology 1998;3(1):37-47
PURPOSE:Growth hormone(GH) therapy is very effective for the treatment of short stature, but it is unconvenient that GH should be injected daily because of short half-life. Sustained-release forms of GH preparation is needed for better compliance. This study aimed to measure peak pattern and duration of release of hGH from solid microparticles using sodium hyaluronate. METHODS:In group 1, hGH(EutropinTM) 285microg/kg was injected subcutaneously to 2 Jindo dogs everyday for 7 days. In group 2, hGH solution(EutropinTM) was continuously infused subcutaneously for 12 hours a day for the first 2 days via mini pump(minimed co.) and then for 24 hours a day thereafter until 7th day with the rate of 11.9microg/kg/hr. In group 3, dose of 2mg/kg hGH in sustained-release formulation using sodium hyaluronate, was injected subcutaneously to 3 Jindo dogs. In group 4, two dose levels of 1mg/kg and 2mg/kg hGH in sustained-release formulation using sodium hyaluronate, were injected subcutaneously to each group of 4 Beagle dogs. To evaluate side reactions from continuous injection of sodium hyaluronate, sustained release form of hGH 2mg/kg was injected to 4 Beagle dogs once a week for 4 weeks and compared to 4 control Beagle dogs. Blood samples were withdrawn half- hourly for 6 hour and 2-4 times a day thereafter in Jindo dogs and at 6hr, 12hr, 22hr in the first day and twice a day(at 9:00, 16:00 O'clock) for the following 6 days. RESULTS:In group 1, peak GH conc. of 122+/-27ng/ml was observed at 1 hour after hGH(EutropinTM) 285microg/kg injection and 1/2 of peak GH conc. at 4 hour. and decreased to 2ng/ml at 24 hour. GH AUC(Area under curve) was 670(ng/ml.hr). In group 2, initial steady state GH conc. of 25ng/ml occurred after 6 hour, however, GH conc. decreased gradually to 16ng/ml at the 7th day. GH AUC based on th initial steady state GH conc. was 600(ng/ml.hr). In group 3(Jindo dogs), GH conc. was peaked at 12 hour and 1/2 of peak GH conc at 30-46 hour and decreased to baseline at 70 hour. GH AUC was 2173(ng/ml.hr). In group 4(Beagle dog), peak GH concentrations of 56+/-7ng/ml and 108+/-12ng/ml were observed at 12 hour for the doses of 1mg/ kg and 2mg/kg, respectively and 1/2 of peak GH conc at 48 hour and decreased to baseline at 80 hour. GH AUC was 3560(ng/ml.h) for 2mg/kg treated dogs. Serum IGF-1 was increased to peak levels of 520ng/ml, and 580ng/ml for the doses of 1mg/kg 2mg/kg, respectively, and persisted above the baseline till 120 hour. There was no specific side reaction during experimental period. CONCLUSION: Sustained-release form of hGH with sodium hyaluronate released GH for 70-80 hour with the peak level lower than that resulted from the conventional aqueous formulation of the equivalent dose, and higher concentration IGF-I maintained for 120 hour after injection above baseline. More extensive study is needed to permit for new therapeutic application.
Animals*
;
Area Under Curve
;
Compliance
;
Dogs
;
Growth Hormone*
;
Half-Life
;
Hyaluronic Acid
;
Insulin-Like Growth Factor I
;
Polymers
6.Medullary Carcinoma of Thyroid Gland with Co-existing Papillary Carcinoma.
Jeong Hee AHN ; So Yong JIN ; Ho Guen KIM ; Chan Il PARK
Korean Journal of Pathology 1988;22(4):443-447
We report a medullary carcinoma of the thyroid gland with a coexisting occult sclerosing papillary carcinoma. This rare case, in that the two types of carcinoma are completely separated and not intermixed together, is different from the previously reported mixed follicular and parafollicular cell carcinomas of the thyroid gland, so-called "differentiated thyroid carcinoma, intermediate type". The two separate tumors of the present case are undoubtedly of coincidental double primaries, and it can be a assumed that at least some of the mixed follicular and parafollicular cell carcinomas are results of collision of carcinomas derived from two embryogenetically different cell types.
7.A Case of laugier-Hunziker syndrome.
Jin Kyung HONG ; So Hee JUNG ; Dong Won LEE ; Jun Young LEE ; Baik Kee CHO
Korean Journal of Dermatology 1999;37(1):113-115
The Laugier-Hunziker syndrome is a rare syndrome characterized by macular hyperpigmentation of the lips and buccal mucosa associated with melanonychia. Onset is usually in adult life and no consistent systemic associations have been reported. Here we report a 39-year-old wonam with a longitudinal pigmented band on a finger and pigmented macules on the lip. We suggest that this is the first report in Korea and the syndrome is presumably more common than recognized.
Adult
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Fingers
;
Humans
;
Hyperpigmentation
;
Korea
;
Lip
;
Mouth Mucosa
8.A Case of Proliferating Trichilemmal Tumor Developing in the Public Area of a Patient Underdoing Hemodialysis.
Youn Jin KIM ; Ji Hyun KIM ; So Yun CHO ; Kyu Kwang WHANG ; Jeong Hee HAHM
Korean Journal of Dermatology 2000;38(5):676-678
No Abstract Available.
Humans
;
Renal Dialysis*
9.Condyloma Accuminatum of the Nipples.
Hee Jin JUN ; So Min KIM ; Hei Sung KIM ; Sang Hyun CHO ; Jeong Deuk LEE
Korean Journal of Dermatology 2014;52(7):508-509
No abstract available.
Nipples*
10.A Case of Squamous Cell Carcinoma of the Skin Resembling Atypical Fibroxanthoma.
So Young JIN ; Woo Hee JUNG ; Kwang Gil LEE ; Jung Bok LEE
Korean Journal of Pathology 1986;20(2):250-253
Both spindle cell variant of squamous cell carcinoma and atypical fibroxanthoma are most commonly presented as a solitary, often ulcerated nodule, occurring on sun-exposed skin of the elderly. These lesions also share the histologic features of diffuse or indistinct fascicular arrangement of polygonal or pulmp spindle cells. Therefore it is not easy to differentiate immunohistochemistry is done. A case of 73 year old woman with squamous cell carcinoma of the skin resembling atypical fibroxanthoma is presented.
Female
;
Humans