Wells' syndrome or eosinophilic cellulitis is an uncommon cutaneous disorder characterized by recurrent erythematous and edematous plaques that often resemble acute cellulitis. The characteristic microscopic findings are diffuse dermal eosinophilia with marked edema, and flame figures consisting of amorphous or granular eosinophilic material around collagen bundles of the dermis. Etiology and pathogenesis are unknown, but the disease has been found to be associated with infections, arthropod bites, drug administration, surgery and hematologic disorders. We report the case of a 55-year-old man with pancreatic carcinoma who was presented with an asymptomatic erythematous to brownish subcutaneous nodule on the left buttock of several days' duration. A biopsy specimen taken from the erythematous to brownish nodule showed many flame figures and diffuse infiltration of eosinophils in the dermis and subcutaneous fat tissue. The rapid resolution of the skin lesion with chemotherapy of the pancreatic carcinoma supports a relationship between the two conditions.
Arthropods ; Biopsy ; Buttocks ; Cellulitis ; Collagen ; Dermis ; Drug Therapy ; Edema ; Eosinophilia ; Eosinophils ; Humans ; Middle Aged ; Skin ; Subcutaneous Fat

No abstract available.
Capsid Proteins* ; Capsid* ; Genome*

The hyperimmunoglobulin E syndrome is a primary immunodificiency disorder characterized by recurrent staphylococcal infections and markedly elevated serum IgE level. Clinical features are coarse face and severe infections of the skin-furunculosis or chronically pruritic dermatitis and sinopulmonary tract infection from infancy by coagulase positive Staphylococcus aureus, or Candida albicans etc. The patients's serum IgE level is elevated but the basic immunologic pathogenesis not fully understood. We have experienced a case of hyperimmunoglobulin E syndrome in a 26/12-year-old who had suffered from recurrent staphylococcal pneumonias and abscesses and chronically pruritic dermatitis from 1 month of age with elevated serum IgE level. A brief review of the related literature is presented.
Abscess ; Candida albicans ; Coagulase ; Dermatitis ; Immunoglobulin E ; Pneumonia, Staphylococcal ; Staphylococcal Infections ; Staphylococcus aureus

OBJECTIVES: Alcohol-induced oxidative stress has been known to injure various tissues or organs. This stress is related with free radicals which are produced as the result of long-term alcohol consumption. Malonyldialdehyde(MDA) is produced by the interaction of free radicals and cell membrane lipids, and indicates the degree of lipid peroxidation indirectly. The purpose of this study was to investigate the relationship between red blood cell(RBC) membrane lipid peroxidation by free radicals, and associated hepatic injuries and hematologic changes. METHODS: Thirty-three subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated within 72 hours after discontinuing alcohol drinking. Clinical characteristics were evaluated by CAGE questionnaire and Korean Michigan Alcoholism Screening Test(MAST). RBC membrane MDA level was measured as the marker of RBC membrane lipid peroxidation. Aspartate aminotransferase(AST), alanine aminotransferase(ALT) and gamma-glutamyltransferase(GGT) were used as the biochemical markers of liver damage due to alcohol ingestion. The alcohol-induced hematologic change was assessed by mean corpuscular volume(MCV). RESULTS: The results were as follows. Clinical characteristics were not different between two groups having normal and abnormal levels of AST, ALT, GGT or MCV. The levels of MDA were not correlated with the clinical characteristics and serum levels of AST, ALT and GGT. However, there was a significant correlation between the levels of MDA and the value of MCV(p=0.017). CONCLUSIONS: These findings suggest that oxidative stress in alcohol dependence may not be reflected in liver enzyme markers such as AST, ALT and GGT, but may be reflected in MCV.
Alanine ; Alcohol Drinking ; Alcoholism* ; Aspartate Aminotransferases ; Aspartic Acid ; Biological Markers ; Diagnostic and Statistical Manual of Mental Disorders ; Eating ; Erythrocyte Indices* ; Erythrocytes* ; Free Radicals ; Humans ; Lipid Peroxidation* ; Liver* ; Mass Screening ; Membrane Lipids ; Membranes* ; Michigan ; Oxidative Stress ; Surveys and Questionnaires

Lanolin is a complex material consisting of a mixture of numerous esters and polyesters of high-moleculer-weight alcohols and fatty acids, Lanolin allergy is important because lanolin is widely used as an emulsifier in topical medicaments and in numerous cosmetic preparations. We report a case of allergic contact dermatitis in a 27-year-old female. An erythematous pruritic rash develgood around the eyelid developed after applying a new eye cream and was aggravated after applying Cambison ophthalmic ointment. Patch testing showed positive reactions to Cambison ophthalmic ointment, 30% wool alcohol, Amerchol L101 and Nivea cream. A use test with 100% Cambison ophthalmic ointment base was positive
Adult ; Alcohols ; Dermatitis, Allergic Contact* ; Esters ; Exanthema ; Eyelids ; Fatty Acids ; Female ; Humans ; Hypersensitivity ; Lanolin* ; Patch Tests ; Polyesters ; Wool

A 13-month-old boy had irregularly shaped, erythematous to dusky red, slightly raised patches and plaques on the left antecubital fossa and arm for 7 months. The lesions were firm and tender. Histopathologically the lesion consisted of small, circumscribed, angiomatous tufts and lobules with a cannonball appearance scattered throughout dermis, a characteristic feature of tufted angioma. For 15 weeks, interferon-a intralesional injections have been performed and the lesions showed an improvement.
Arm ; Dermis ; Hemangioma* ; Humans ; Infant ; Injections, Intralesional ; Interferon-alpha* ; Male

No abstract available.
Vena Cava, Superior*

For the reconstruction of skin defects after remoral of cutanous tumors in the nasal area, local flaps or full-thickness skin grafts can be utilized depending on the size and site of the defectg. Burows graft, which is, variant of the full-thickness skin graft, makes use of the skin nearby as the donor site, minimizes deformity of the recipient site, maximizes ireservation of skin, easily aligns relaxed skin tension line, and is thus one of the methods with a good esultant color and texture match. A pigmented basal cell carcinoma on the nasal bridge in a 51-year old male was remaved by 4 serial sections of Mohs micrograplic surgery and was then successfully enstructed using a Burows graft.
Carcinoma, Basal Cell* ; Congenital Abnormalities ; Humans ; Male ; Middle Aged ; Mohs Surgery* ; Skin ; Tissue Donors ; Transplants*

PURPOSE: This study was conducted to identify the effects of early exercise education using videos on exercise knowledge and compliance of elderly patients who undergo total knee replacement surgery. METHODS: This is a quasi-experimental study with a nonequivalent control group non-synchronized design. The participants were 70 elderly patients who had total knee arthroplasty in the C university hospital located in G city, Korea. Thirty-five patients were assigned to an experimental group and the other patients were assigned to a control group. After the total knee arthroplasty, the early exercise education accompanied by watching video instruction was conducted on the experimental group at post-operation second and third day for 15 minutes. General exercise education was administered to the control group. The exercise knowledge and compliance of the elderly patients were measured through structured questionnaires. CONCLUSION: The results of this study indicate that early exercise education using videos has positive effects to improve the exercise knowledge and compliance of elderly patients after total knee arthroplasty. This early exercise education can be used going forward as nursing intervention for elderly patients who undergo total knee replacement surgery.
Aged* ; Arthroplasty ; Arthroplasty, Replacement, Knee* ; Compliance* ; Education* ; Humans ; Knee ; Korea ; Non-Randomized Controlled Trials as Topic ; Nursing

BACKGROUND: Nipple and areola diseases of the breast cause cosmetic, sexual and functional problems, and these problems are important to most patients, so awareness of these disease entities is invaluable. Still, there has been insufficient clinical investigation of these conditions. OBJECTIVE: This study was performed to investigate the epidemiological aspects of nipple and areola diseases that were confirmed by biopsies, and we wanted to highlight the clinical features of dermatoses of the nipple and areola. These disease features were then compared between the patients who visited the Departments of Dermatology and General Surgery. METHODS: We retrospectively reviewed the data of 80 patients with nipple and areola lesions and these lesions were confirmed by biopsy at Maryknoll Hospital between March 1989 and August 2007. 37 patients visited the Department of Dermatology and 43 patients visited the Department of General Surgery. RESULTS: The ratio of males to females was 6:74. The ratio of the males to females seen at the Department of Dermatology was 6:31. In contrast, that of the patients seen at the Department of General Surgery was 0:43. The most frequent nipple and areola skin diseases were fibroadenoma, intraductal papilloma, accessory breast and nipple eczema in the decreasing order of frequency. The most frequent nipple and areola skin diseases seen at the Department of Dermatology were nipple eczema, soft fibroma, hyperkeratosis of the nipple and areola, Paget's disease and invasive ductal carcinoma in the decreasing order of frequency. In contrast, the most frequent nipple and areola skin diseases seen at the Department of General Surgery were fibroadenoma, intraductal papilloma, accessory breast, phyllodes tumor and subareolar abscess. Of the 80 cases, 49 had papules or nodules, 15 had patches or plaques, 10 had vesicles, erosions or ulcers and 6 had nipple discharge. Of the 37 cases seen at the Department of Dermatology, 15 had patches or plaques, 14 had papules or nodules and 8 had vesicles, erosions or ulcers. In contrast, of the 43 cases seen at the Department of General Surgery, 35 had papules or nodules, 6 had bloody or serous nipple discharge, and 2 had vesicles, erosions or ulcers. CONCLUSION: We retrospectively studied 80 cases of nipple and areola skin diseases. This study suggests that various conditions, including dysembryoplasia, inflammatory dermatoses, hyperkeratoses and neoplasm, can affect the nipple and areola and show different characteristics according to the Hospital Department they are seen at. The patients with symptoms of patches or plaques tend to visit the Department of Dermatology. In contrast, patients with symptoms of papules or nodules tend to visit the Department of General Surgery. Further investigation with a large group of patients is necessary to better understand the epidemiology of nipple and areola skin diseases.
Abscess ; Biopsy ; Breast ; Breast Diseases ; Carcinoma, Ductal ; Cosmetics ; Dermatology ; Eczema ; Female ; Fibroadenoma ; Fibroma ; Hospital Departments ; Humans ; Male ; Nipples ; Papilloma, Intraductal ; Phyllodes Tumor ; Retrospective Studies ; Skin ; Skin Diseases ; Ulcer